{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:18:04Z","timestamp":1792153084340,"version":"4.4.0"},"reference-count":25,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":1935,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Context: Postmenopausal osteoporosis is a public health problem. Diabetics are at increased risk of osteoporosis-related fractures. Zinc (Zn) has a role in collagen metabolism, and its levels are altered in diabetes.<\/jats:p><jats:p>\n          Aims: The aim was to compare bone mineral density (BMD), T-score and serum Zn between diabetic and nondiabetic postmenopausal women with osteoporosis to see if they influence increased fracture risk in diabetes.<\/jats:p><jats:p>\n          Settings and Design: It is a cross-sectional study conducted at Department of Biochemistry, Jawaharlal Nehru Medical College, Belgaum.<\/jats:p><jats:p>\n          Materials and Methods: Thirty type 2 diabetic and 30 age-matched (aged 45-75 years) nondiabetic Dual energy X-ray absorptiometry (DEXA) confirmed postmenopausal osteoporotics were included from January 2011 to March 2012. Serum Zn was analyzed by atomic absorption spectrophotometry.<\/jats:p><jats:p>\n          Statistical Analysis Used: Mean and standard deviation of the parameters of the two groups were computed and compared by unpaired Student's t-test. Relationship between variables was measured by Karl Pearson's correlation co-efficient. A statistical significance is set at 5% level of significance (P &lt; 0.05).<\/jats:p><jats:p>\n          Results: T-score was significantly higher in diabetics compared with nondiabetics(\u22122.84 \u00b1 0.42 vs. \u22123.22 \u00b1 0.74) P &lt; 0.05. BMD and serum Zn of diabetics showed a significant positive correlation with body mass index (BMI).<\/jats:p><jats:p>\n          Conclusions: Type 2 diabetic postmenopausal osteoporotics have a higher T-score than the nondiabetics. High BMI in type-2 diabetes mellitus (T2DM) may contribute to high BMD and may be a protective factor against zincuria. Increased fracture risk in T2DM could be due to other factors like poor bone quality due to hyperglycemia rather than BMD. Strict glycemic control is of paramount importance.<\/jats:p>","DOI":"10.4103\/0974-2727.151681","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T09:32:45Z","timestamp":1424251965000},"page":"043-048","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of Bone Mineral Density, T-Scores and Serum Zinc between Diabetic and Non Diabetic Postmenopausal Women with Osteoporosis"],"prefix":"10.25259","volume":"7","author":[{"given":"Priyanka R","family":"Siddapur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Nehru Medical College, KLE University, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha B","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Nehru Medical College, KLE University, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha S","family":"Borde","sequence":"additional","affiliation":[{"name":"Department of Physiology, Jawaharlal Nehru Medical College, KLE University, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"key-10.4103\/0974-2727.151681-1","first-page":"164","volume-title":"Recent update on osteoporosis","author":"Agrawal","year":"2013","journal-title":"Int J Med Sci Public Health"},{"key":"key-10.4103\/0974-2727.151681-2","first-page":"564","volume-title":"Magnesium, zinc, copper, manganese, and selenium levels in postmenopausal women with osteoporosis.Can magnesium play a key role in osteoporosis?","author":"Odabasi","year":"2008","journal-title":"Ann Acad Med Singapore"},{"key":"key-10.4103\/0974-2727.151681-3","unstructured":"Linsay R, Cosman F. Osteoporosis. In: Longo DL, editor. Harrison\u2032s Principles of Internal Medicine. 18 th ed. United States of America: McGraw-Hill Publishers; 2012. p. 3120-35."},{"key":"key-10.4103\/0974-2727.151681-4","first-page":"431","volume-title":"Profile of a menopause clinic in an urban population in Malaysia","author":"Damodaran","year":"2000","journal-title":"Singapore Med J"},{"key":"key-10.4103\/0974-2727.151681-5","first-page":"263","volume-title":"Osteoporosis in Indians","author":"Malhotra","year":"2008","journal-title":"Indian J Med Res","ISSN":"https:\/\/id.crossref.org\/issn\/0971-5916","issn-type":"print"},{"key":"key-10.4103\/0974-2727.151681-6","first-page":"153","volume-title":"Osteoporosis and diabetes","author":"Chau","year":"2002","journal-title":"Clin Diabetes"},{"key":"key-10.4103\/0974-2727.151681-7","first-page":"1317","volume-title":"Osteoporosis in patients with diabetes mellitus","author":"Hofbauer","year":"2007","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/0974-2727.151681-8","first-page":"715","volume-title":"Zinc intakes and plasma concentrations in men with osteoporosis: The Rancho Bernardo Study","author":"Hyun","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"key-10.4103\/0974-2727.151681-9","first-page":"6","volume-title":"Zinc homeostasis and bone mineral density","author":"Molokwu","year":"2006","journal-title":"Ohio Res Clin Rev"},{"key":"key-10.4103\/0974-2727.151681-10","first-page":"795","volume-title":"The status of trace elements after menopause: A comparative study","author":"Gupta","year":"2011","journal-title":"J Clin Diagn Res"},{"key":"key-10.4103\/0974-2727.151681-11","first-page":"283","volume-title":"Glycemic control of type 2 diabetic patients after short-term zinc supplementation","author":"Oh","year":"2008","journal-title":"Nutr Res Pract"},{"key":"key-10.4103\/0974-2727.151681-12","first-page":"1","volume-title":"Blood Sugar lowering effect of zinc and multi vitamin\/mineral supplementation is dependent on initial fasting blood glucose","author":"Gunasekara","year":"2011","journal-title":"J Diabetol"},{"key":"key-10.4103\/0974-2727.151681-13","unstructured":"Powers AC. Diabetes mellitus. In: Longo DL, editor. Harrison\u2032s Principles of Internal Medicine. 18 th ed. United States of America: McGraw-Hill Publishers; 2012. p. 2968-3003."},{"key":"key-10.4103\/0974-2727.151681-14","first-page":"24","volume-title":"Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor","author":"Trinder","year":"1969","journal-title":"Ann Clin Biochem"},{"key":"key-10.4103\/0974-2727.151681-15","first-page":"193","volume-title":"Osteoporosis among patients with type 1 and type 2 diabetes","author":"R\u00e4kel","year":"2008","journal-title":"Diabetes Metab"},{"key":"key-10.4103\/0974-2727.151681-16","first-page":"319","volume-title":"Association between bone mineral density and type 2 diabetes mellitus: A meta-analysis of observational studies","author":"Ma","year":"2012","journal-title":"Eur J Epidemiol"},{"key":"key-10.4103\/0974-2727.151681-17","first-page":"665","volume-title":"Copper, zinc, and magnesium levels in non-insulin dependent diabetes mellitus","author":"Zargar","year":"1998","journal-title":"Postgrad Med J"},{"key":"key-10.4103\/0974-2727.151681-18","first-page":"122","volume-title":"Serum zinc, chromium and magnesium levels in Type 2 diabetes","author":"Diwan","year":"2006","journal-title":"Int J Diabetes Dev Ctries"},{"key":"key-10.4103\/0974-2727.151681-19","first-page":"93","volume-title":"Serum chromium, zinc and testosterone levels in diabetics in university of Calabar Teaching Hospital Calabar Nigeria","author":"Emeribe","year":"2012","journal-title":"J Biol Agric Healthc"},{"key":"key-10.4103\/0974-2727.151681-20","first-page":"359","volume-title":"Zinc deficiency and clinical practice","author":"Yanagisawa","year":"2004","journal-title":"Jpn Med Assoc J"},{"key":"key-10.4103\/0974-2727.151681-21","first-page":"2279","volume-title":"Zinc intake and biochemical markers of bone turnover in type 1 diabetes","author":"Maser","year":"2008","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.151681-22","first-page":"109","volume-title":"Zinc, insulin and diabetes","author":"Chausmer","year":"1998","journal-title":"J Am Coll Nutr"},{"key":"key-10.4103\/0974-2727.151681-23","first-page":"1050","volume-title":"Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus","author":"Walter","year":"1991","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.151681-24","first-page":"10","volume-title":"Osteoporosis: An under-appreciated complication of diabetes","author":"Brown","year":"2004","journal-title":"Clin Diabetes"},{"key":"key-10.4103\/0974-2727.151681-25","unstructured":"Florence R, Allen S, Benedict L, Compo R, Jensen A, Kalogeropoulou D, et al. In: Diagnosis and Treatment of Osteoporosis. 8 th ed. Bloomington: Institute for Clinical Systems Improvement; 2013. p. 1-87."}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0974-2727.151681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:13:56Z","timestamp":1703405636000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/comparison-of-bone-mineral-density-t-scores-and-serum-zinc-between-diabetic-and-non-diabetic-postmenopausal-women-with-osteoporosis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":25,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,4,19]]},"published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2727.151681","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}