{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:04:36Z","timestamp":1791849876779,"version":"4.3.4"},"reference-count":23,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":1754,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Background: Insulin resistance (IR) is the key pathophysiological defect that leads to the development of type 2 diabetes mellitus. The purpose of this study was to estimate serum magnesium level and insulin sensitivity indices among type 2 diabetes mellitus patients and to see an association between them.<\/jats:p><jats:p>\n          Methods: This study was carried out among 38 type 2 diabetic patients and forty age and sex matched controls. Serum fasting glucose, magnesium, insulin, urea, and creatinine levels were estimated. Insulin sensitivity indices, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) levels were calculated as per formulae.<\/jats:p><jats:p>\n          Results: A highly significant low serum magnesium level was found in diabetic subjects as compared to the controls. Statistically significant high HOMA levels (&gt;2.6) and low QUICKI levels (&lt; 0.33) were found among the case group. An inverse, statistically significant correlation was found between serum magnesium and fasting insulin level. A highly statistically significant inverse correlation was found between serum magnesium and HOMA level, and a positive correlation was found between serum magnesium and QUICKI level, that is, serum magnesium level decreases with increase in IR. A strong association was also found between fasting serum insulin level and insulin sensitivity indices.<\/jats:p><jats:p>\n          Conclusion: This study showed a lower serum magnesium level in diabetic patients compared to control. A strong association was also found between serum magnesium level and insulin sensitivity indices. For proper management of type 2 diabetes, it may, therefore, be necessary to treat hypomagnesemia in these patients.<\/jats:p>","DOI":"10.4103\/0974-2727.163131","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T08:55:34Z","timestamp":1439974534000},"page":"075-078","source":"Crossref","is-referenced-by-count":42,"title":["Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus"],"prefix":"10.25259","volume":"7","author":[{"given":"Happy","family":"Chutia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyrshanlang G","family":"Lynrah","sequence":"additional","affiliation":[{"name":"Department of General Medicine, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"key-10.4103\/0974-2727.163131-1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. Diabetes Care 2014;37 Suppl 1:S81-90.","DOI":"10.2337\/dc14-S081"},{"key":"key-10.4103\/0974-2727.163131-2","unstructured":"International Diabetes Federation. Diabetes Atlas. 3rd ed. Brussels: International Diabetes Federation; 2006"},{"key":"key-10.4103\/0974-2727.163131-3","first-page":"1149","volume-title":"IRIS II study: The IRIS II score \u2013 Assessment of a new clinical algorithm for the classification of insulin resistance in patients with Type 2 diabetes","author":"Forst","year":"2004","journal-title":"Diabet Med"},{"key":"key-10.4103\/0974-2727.163131-4","unstructured":"Hanefeld M. The metabolic syndrome: Roots, myths, and facts. In: Hanefeld M, Leonhardt W, editors. The Metabolic Syndrome. Jena: Gustav Fischer; 1997. p. 13-24."},{"key":"key-10.4103\/0974-2727.163131-5","first-page":"1440","volume-title":"Diabetes mellitus its differentiation into insulin sensitive and insulin insensitive types.Lancet 1936","author":"Himsworth","year":"2011","journal-title":"Diabet Med"},{"key":"key-10.4103\/0974-2727.163131-6","first-page":"460","volume-title":"Diagnosing insulin resistance in the general population","author":"McAuley","year":"2001","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.163131-7","first-page":"1462","volume-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.163131-8","first-page":"314","volume-title":"Indexes of insulin resistance and secretion in obese children and adolescents: A validation study","author":"Conwell","year":"2004","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.163131-9","first-page":"36","volume-title":"Surrogate markers of insulin resistance: A review","author":"Singh","year":"2010","journal-title":"World J Diabetes"},{"key":"key-10.4103\/0974-2727.163131-10","unstructured":"Kendall DM. Targeting Insulin Resistance: Diabetes Prevention, Cardiovascular Disease Risk, and the Thiozolidinediones. In Medscape Coverage of American Diabetes Association; 64th Annual Scientific Sessions; 2004."},{"key":"key-10.4103\/0974-2727.163131-11","unstructured":"Badyal A, Sodhi KS, Pandey R, Singh J. Serum magnesium levels: A key issue for diabetes mellitus. Jk Science 2011;13:3. Available from: www.jkscience.org."},{"key":"key-10.4103\/0974-2727.163131-12","first-page":"509","volume-title":"Serum magnesium and type-2 diabetes in African Americans and Hispanics: A New York cohort","author":"Chambers","year":"2006","journal-title":"J Am Coll Nutr"},{"key":"key-10.4103\/0974-2727.163131-13","first-page":"1000","volume-title":"Hypomagnesemia in type 2 diabetes mellitus","author":"Dasgupta","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"key-10.4103\/0974-2727.163131-14","first-page":"366","volume-title":"Hypomagnesemia in patients with type 2 diabetes","author":"Pham","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"key-10.4103\/0974-2727.163131-15","first-page":"419","volume-title":"Higher magnesium intake reduces risk of impaired glucose and insulin metabolism and progression from prediabetes to diabetes in middle-aged Americans","author":"Hruby","year":"2014","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.163131-16","first-page":"429","volume-title":"Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2","author":"Pham","year":"2005","journal-title":"Clin Nephrol"},{"key":"key-10.4103\/0974-2727.163131-17","first-page":"121","volume-title":"Magnesium metabolism in chronic renal failure","author":"Mountokalakis","year":"1990","journal-title":"Magnes Res"},{"key":"key-10.4103\/0974-2727.163131-18","first-page":"1487","volume-title":"Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: The Hisayama Study","author":"Hata","year":"2013","journal-title":"Diabet Med"},{"key":"key-10.4103\/0974-2727.163131-19","first-page":"959","volume-title":"Magnesium deficiency and insulin resistance in patients with type 2 diabetes mellitus","author":"Lima","year":"2005","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"key-10.4103\/0974-2727.163131-20","first-page":"2116","volume-title":"Magnesium intake and risk of type 2 diabetes: Meta-analysis of prospective cohort studies","author":"Dong","year":"2011","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.163131-21","first-page":"39","volume-title":"Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X","author":"Barbagallo","year":"2003","journal-title":"Mol Aspects Med"},{"key":"key-10.4103\/0974-2727.163131-22","first-page":"253","volume-title":"Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance.A double-blind placebo-controlled randomized trial","author":"Guerrero-Romero","year":"2004","journal-title":"Diabetes Metab"},{"key":"key-10.4103\/0974-2727.163131-23","first-page":"281","volume-title":"Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects \u2013 A double-blind, placebo-controlled, randomized trial","author":"Mooren","year":"2011","journal-title":"Diabetes Obes Metab"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0974-2727.163131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:14:00Z","timestamp":1703405640000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/association-of-serum-magnesium-deficiency-with-insulin-resistance-in-type-2-diabetes-mellitus\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":23,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,4,19]]},"published-print":{"date-parts":[[2015,7]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2727.163131","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}