{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:31:42Z","timestamp":1761863502814},"reference-count":31,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":1570,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Background and Objectives: The liver plays a pivotal role in carbohydrate metabolism. Therefore, functional state of the liver in patients with diabetes is of interest. The objectives of the current study were to (i) identify co-existent biochemical derangements of liver function tests (LFTs) in type 2 diabetes and (ii) determine the association between liver function parameters and glycemic status in type 2 diabetics from Shillong, Meghalaya.<\/jats:p><jats:p>\n          Materials and Methods: Data from 320 type 2 diabetes patients were screened retrospectively for abnormalities in LFTs. Relationship of fasting serum glucose was assessed with the following tests in the LFT panel: Total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and albumin. Correlation coefficient was computed between individual LFT and fasting glucose status. These bivariate analyses were supplemented by multivariate linear regression analyses.<\/jats:p><jats:p>\n          Results: 71.25% subjects had an abnormality in at least one LFT. Elevated ALT (46.8%) and elevated ALP (48.5%) were the most common abnormality in males and females, respectively. ALP correlated positively with fasting glucose in both sexes. AST, ALT, and ALP were found to be independent determinants of glycemic status.<\/jats:p><jats:p>\n          Conclusion: Derangements in liver function are widely co-existent in type 2 diabetics from Shillong. Deranged liver enzymes are associated with glycemic status. Screening for liver dysfunction in diabetics and subsequent workup may lead to the identification of hepatic co-morbidities and better management.<\/jats:p>","DOI":"10.4103\/0974-2727.176227","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T08:51:43Z","timestamp":1455267103000},"page":"030-035","source":"Crossref","is-referenced-by-count":11,"title":["Presence of Concurrent Derangements of Liver Function Tests in Type 2 Diabetes and Their Relationship with Glycemic Status: A Retrospective Observational Study from Meghalaya"],"prefix":"10.25259","volume":"8","author":[{"given":"Kaustubh","family":"Bora","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghna","family":"Borah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Happy","family":"Chutia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan Kumar","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulmoni","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Mental Health Nursing, Army Institute of Nursing, Guwahati, Assam, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Abraham","family":"Ruram","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"key-10.4103\/0974-2727.176227-1","first-page":"S62","volume-title":"Diagnosis and classification of diabetes mellitus","author":"American","year":"2008","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.176227-2","doi-asserted-by":"crossref","unstructured":"Dufour DR. Chapter: Liver disease. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed., 1st Indian Reprint. India: Elsevier (Reed Elsevier India Private Limited); 2012. p. 1637-93.","DOI":"10.1016\/B978-1-4160-6164-9.00050-0"},{"key":"key-10.4103\/0974-2727.176227-3","first-page":"65","volume-title":"The role of primary care professionals in managing diabetes","author":"Saudek","year":"2002","journal-title":"Clin Diabetes"},{"key":"key-10.4103\/0974-2727.176227-4","first-page":"290","volume-title":"Diabetes mellitus and liver dysfunction; etiologic and therapeutic considerations","author":"Leevy","year":"1950","journal-title":"Am J Med"},{"key":"key-10.4103\/0974-2727.176227-5","first-page":"248","volume-title":"Liver function tests in diabetic patients","author":"Salmela","year":"1984","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.176227-6","first-page":"1012","volume-title":"Raised liver enzymes in newly diagnosed Type 2 diabetes are associated with weight and lipids, but not glycaemic control","author":"Saligram","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"key-10.4103\/0974-2727.176227-7","first-page":"36","volume-title":"Determinants of abnormal liver function tests in diabetes patients in Myanmar","author":"Ni","year":"2012","journal-title":"Int J Diabetes Res"},{"key":"key-10.4103\/0974-2727.176227-8","first-page":"146","volume-title":"Prevalence of elevated liver enzymes in Type 2 diabetes mellitus and its association with the metabolic syndrome","author":"Forlani","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"key-10.4103\/0974-2727.176227-9","first-page":"626","volume-title":"Alkaline phosphatase: Can it be considered as an indicator of liver fibrosis in non-alcoholic steatohepatitis with type 2 diabetes?","author":"Kocabay","year":"2011","journal-title":"Bratisl Lek Listy"},{"key":"key-10.4103\/0974-2727.176227-10","first-page":"305","volume-title":"Liver enzymes, type 2 diabetes, and metabolic syndrome in middle-aged, urban Chinese men","author":"Villegas","year":"2011","journal-title":"Metab Syndr Relat Disord"},{"key":"key-10.4103\/0974-2727.176227-11","first-page":"713","volume-title":"One-hour post-load plasma glucose levels are associated with elevated liver enzymes","author":"Succurro","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"key-10.4103\/0974-2727.176227-12","first-page":"181","volume-title":"Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus","author":"Zhang","year":"2010","journal-title":"Endocrine"},{"key":"key-10.4103\/0974-2727.176227-13","first-page":"1841","volume-title":"Liver enzymes as a predictor for incident diabetes in a Japanese population: The Hisayama study","author":"Doi","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"key-10.4103\/0974-2727.176227-14","first-page":"e51496","volume-title":"Liver function tests and risk prediction of incident type 2 diabetes: Evaluation in two independent cohorts","author":"Abbasi","year":"2012","journal-title":"PLoS One"},{"key":"key-10.4103\/0974-2727.176227-15","first-page":"159","volume-title":"Liver aminotransferases and risk of incident type 2 diabetes: A systematic review and meta-analysis","author":"Kunutsor","year":"2013","journal-title":"Am J Epidemiol"},{"key":"key-10.4103\/0974-2727.176227-16","first-page":"2116","volume-title":"Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: The EPIC-Potsdam Study","author":"Schulze","year":"2009","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.176227-17","first-page":"1047","volume-title":"Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0974-2727.176227-18","first-page":"164","volume-title":"Hepatic dysfunction in diabetes mellitus: Biochemical and ultrasonological study","author":"Prabhudeva","year":"2014","journal-title":"J Acad Ind Res"},{"key":"key-10.4103\/0974-2727.176227-19","first-page":"544","volume-title":"Alarming high levels of transaminases in non-insulin dependent diabetes mellitus","author":"Chitkara","year":"2014","journal-title":"Indian J Basic Appl Med Res"},{"key":"key-10.4103\/0974-2727.176227-20","first-page":"388","volume-title":"Liver function tests in type 2 diabetes mellitus patients with and without oral hypoglycemic agents and statin intake","author":"Patra","year":"2012","journal-title":"Indian Med Gaz"},{"key":"key-10.4103\/0974-2727.176227-21","first-page":"122","volume-title":"Liver dysfunction in diabetes patients admitted in referral hospital","author":"Takhelmayum","year":"2014","journal-title":"Bali Med J"},{"key":"key-10.4103\/0974-2727.176227-22","unstructured":"Kratz A, Sluss PM, Januzzi JL Jr., Lewandrowski KB. Appendices: Laboratory values of clinical importance. In: Kasper DL, Fauci AS, Longo DL, Braunwald E, Hauser SL, Jameson JL, editors. Harrison's Principles of Internal Medicine. 16th ed. The United States of America: The McGraw-Hill Companies, Inc.; 2005. p. A1-7."},{"key":"key-10.4103\/0974-2727.176227-23","first-page":"8","volume-title":"Elevation of serum alkaline phosphatase activity and related enzymes in diabetes mellitus","author":"Goldberg","year":"1977","journal-title":"Clin Biochem"},{"key":"key-10.4103\/0974-2727.176227-24","first-page":"157","volume-title":"Prevalence of abnormal liver function tests in patients with diabetes mellitus","author":"Gonem","year":"2007","journal-title":"Endocr Abstr"},{"key":"key-10.4103\/0974-2727.176227-25","first-page":"17","volume-title":"Liver function tests in type 2 Sudanese diabetic patients","author":"Idris","year":"2011","journal-title":"Int J Nutr Metab"},{"key":"key-10.4103\/0974-2727.176227-26","first-page":"115","volume-title":"Elevated liver function tests in type 2 diabetes","author":"Harris","year":"2005","journal-title":"Clin Diabetes"},{"key":"key-10.4103\/0974-2727.176227-27","first-page":"448","volume-title":"Study of prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes patients in India (SPRINT)","author":"Kalra","year":"2013","journal-title":"J Assoc Physicians India"},{"key":"key-10.4103\/0974-2727.176227-28","first-page":"193","volume-title":"Liver disease and diabetes mellitus","author":"Baig","year":"2001","journal-title":"Clin Lab Med"},{"key":"key-10.4103\/0974-2727.176227-29","first-page":"53","volume-title":"Liver disease and diabetes: Association, pathophysiology, and management","author":"Ahmadieh","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"key-10.4103\/0974-2727.176227-30","first-page":"1254, 1256","volume-title":"Chronic liver diseases and diabetes","author":"Jaafar","year":"2014","journal-title":"Rev Med Suisse"},{"key":"key-10.4103\/0974-2727.176227-31","first-page":"156","volume-title":"Diabetes co-existing with chronic liver disease: Clinical features and response to therapy","author":"Chuhwak","year":"2007","journal-title":"Niger J Med"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0974-2727.176227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:14:10Z","timestamp":1703405650000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/presence-of-concurrent-derangements-of-liver-function-tests-in-type-2-diabetes-and-their-relationship-with-glycemic-status-a-retrospective-observational-study-from-meghalaya\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":31,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,4,19]]},"published-print":{"date-parts":[[2016,1]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2727.176227","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}