{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:07:43Z","timestamp":1703462863530},"reference-count":15,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":1570,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Subependymal giant cell astrocytoma (SEGA) is a low grade (WHO Grade I) tumor, usually seen in patients with tuberous sclerosis complex and commonly occurs at a lateral ventricular location. Intraoperative squash cytologic features can help in differentiating SEGA from gemistocytic astrocytoma (GA), giant cell glioblastoma and ependymoma, in proper clinical context and radiological findings, which may alter the surgical management. Here, we present a case of SEGA with squash cytologic findings and a review of cytology findings of SEGA presently available in the literature. Loose cohesive clusters of large polygonal cells containing an eccentric nucleus, evenly distributed granular chromatin, distinct to prominent nucleoli, and moderate to the abundant eosinophilic cytoplasm in a hair-like fibrillar background are the key cytologic features of SEGA. Other important features are moderate anisonucleosis and frequent binucleation and multinucleation. The absence of mitoses, necrosis, and vascular endothelial proliferation are important negative features. Other consistent features are cellular smears, few dispersed cells, few spindly strap-like cells, rare intranuclear cytoplasmic inclusion, and perivascular pseudorosettes.<\/jats:p>","DOI":"10.4103\/0974-2727.176231","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T08:51:43Z","timestamp":1455267103000},"page":"058-061","source":"Crossref","is-referenced-by-count":2,"title":["Intraoperative Squash Cytologic Features of Subependymal Giant Cell Astrocytoma"],"prefix":"10.25259","volume":"8","author":[{"given":"Jitendra","family":"Nasit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College and Sir Sayajirao General Hospital, Baroda, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viren","family":"Vaghsiya","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College and Sir Sayajirao General Hospital, Baroda, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srilaxmi","family":"Hiryur","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College and Sir Sayajirao General Hospital, Baroda, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical College and Sir Sayajirao General Hospital, Baroda, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,4,19]]},"reference":[{"key":"key-10.4103\/0974-2727.176231-1","first-page":"445","volume-title":"Cytologic features of subependymal giant cell astrocytom: A review of 7 cases","author":"Takei","year":"2008","journal-title":"Acta Cytol"},{"key":"key-10.4103\/0974-2727.176231-2","first-page":"333","volume-title":"Squash cytology of subependymal giant cell astrocytoma: Report of four cases with brief 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astrocytoma","author":"Altermatt","year":"1992","journal-title":"Acta Cytol"},{"key":"key-10.4103\/0974-2727.176231-7","first-page":"39","volume-title":"Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas","author":"Grajkowska","year":"2011","journal-title":"Folia Neuropathol"},{"key":"key-10.4103\/0974-2727.176231-8","first-page":"76","volume-title":"Subependymal giant cell astrocytoma with atypical clinical and pathological features: A diagnostic pitfall","author":"Svajdler","year":"2013","journal-title":"Cesk Patol"},{"key":"key-10.4103\/0974-2727.176231-9","first-page":"550","volume-title":"Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: A case report","author":"Kawasaki","year":"1999","journal-title":"No Shinkei Geka"},{"key":"key-10.4103\/0974-2727.176231-10","first-page":"139","volume-title":"Subependymal giant cell astrocytoma: A clinicopathological study of 23 cases with special emphasis on proliferative markers and expression of p53 and retinoblastoma gene proteins","author":"Sharma","year":"2004","journal-title":"Pathology"},{"key":"key-10.4103\/0974-2727.176231-11","first-page":"498","volume-title":"Subependymal giant cell astrocytoma with cranial and spinal metastases in a patient with tuberous sclerosis.Case report","author":"Telfeian","year":"2004","journal-title":"J Neurosurg"},{"key":"key-10.4103\/0974-2727.176231-12","first-page":"181","volume-title":"Solitary subependymal giant cell astrocytoma incidentally found at autopsy in an elderly woman without tuberous sclerosis complex","author":"Takei","year":"2009","journal-title":"Neuropathology"},{"key":"key-10.4103\/0974-2727.176231-13","first-page":"25","volume-title":"Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma.Morphological, immunohistochemical and ultrastructural study?","author":"Buccoliero","year":"2009","journal-title":"Neuropathology"},{"key":"key-10.4103\/0974-2727.176231-14","first-page":"359","volume-title":"BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas","author":"Lee","year":"2015","journal-title":"J Surg Oncol"},{"key":"key-10.4103\/0974-2727.176231-15","first-page":"1035","volume-title":"Thyroid transcription factor-1 and epithelial membrane antigen expression in four cases of subependymal giant cell astrocytoma","author":"Chatzopoulos","year":"2015","journal-title":"Histopathology"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0974-2727.176231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:14:12Z","timestamp":1703405652000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/intraoperative-squash-cytologic-features-of-subependymal-giant-cell-astrocytoma\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":15,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,4,19]]},"published-print":{"date-parts":[[2016,1]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2727.176231","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}