{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:34:23Z","timestamp":1792658063686,"version":"4.5.0"},"reference-count":101,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":3680,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Endometriosis is found predominantly in women of childbearing age. The prevalence of endometriosis is difficult to determine accurately. Laparoscopy or surgery is required for the definitive diagnosis. The most common symptoms are dysmenorrhea, dyspareunia, and low back pain that worsen during menses. Endometriosis occurring shortly after menarche has been frequently reported. Endometriosis has been described in a few cases at the umbilicus, even without prior history of abdominal surgery. It has been described in various atypical sites such as the fallopian tubes, bowel, liver, thorax, and even in the extremities. The most commonly affected areas in decreasing order of frequency in the gastrointestinal tract are the recto-sigmoid colon, appendix, cecum, and distal ileum. The prevalence of appendiceal endometriosis is 2.8%. Malignant transformation is a well-described, although rare (&lt;1% of cases), complication of endometriosis. Approximately 75% of these tumors arise from endometriosis of the ovary. Other less common sites include the rectovaginal septum, rectum, and sigmoid colon. Unopposed estrogens therapy may play a role in the development of such tumors. A more recent survey of 27 malignancies associated with endometriosis found that 17 (62%) were in the ovary, 3 (11%) in the vagina, 2 (7%) each in the fallopian tube or mesosalpinx, pelvic sidewall, and colon, and 1 (4%) in the parametrium. Two cases of cerebral endometriosis and a case of endometriosis presenting as a cystic mass in the cerebellar vermis has been described. Treatment for endometriosis can be expectant, medical, or surgical depending on the severity of symptoms and the patient\u2019s desire to maintain or restore fertility.<\/jats:p>","DOI":"10.4103\/0974-2727.66699","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T01:22:58Z","timestamp":1279848178000},"page":"001-009","source":"Crossref","is-referenced-by-count":84,"title":["Endometriosis - Morphology, clinical presentations and molecular pathology"],"prefix":"10.25259","volume":"2","author":[{"given":"Neha","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma centre, AIIMS, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arulselvi","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma centre, AIIMS, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"key-10.4103\/0974-2727.66699-1","first-page":"1154","volume-title":"Nonpigmented endometriosis: clinical, laparoscopic, and pathologic definition","author":"Jansen","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"key-10.4103\/0974-2727.66699-2","first-page":"1023","volume-title":"Malignant neoplasms arising in endometriosis","author":"Heaps","year":"1990","journal-title":"Obstet Gynecol"},{"key":"key-10.4103\/0974-2727.66699-3","first-page":"412","volume-title":"Endometriosis and mullerian anomalies","author":"Olive","year":"1987","journal-title":"Obstet Gynecol"},{"key":"key-10.4103\/0974-2727.66699-4","first-page":"620","volume-title":"Are there any clinical signs and symptoms that are related to endometriosis in infertile women?","author":"Matorras","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"key-10.4103\/0974-2727.66699-5","first-page":"238","volume-title":"Changing trends in the diagnosis of endometriosis: a comparative study of women with pelvic endometriosis presenting with chronic pelvic pain or infertility","author":"Dmowski","year":"1997","journal-title":"Fertil Steril"},{"key":"key-10.4103\/0974-2727.66699-6","first-page":"251","volume-title":"Laparoscopy in the diagnosis and management of pelvic pain in adolescents","author":"Goldstein","year":"1989","journal-title":"J Reprod Med"},{"key":"key-10.4103\/0974-2727.66699-7","first-page":"156","volume-title":"Endometriosis in adolescents","author":"Chatman","year":"1982","journal-title":"J Reprod Med"},{"key":"key-10.4103\/0974-2727.66699-8","first-page":"44","volume-title":"Endometriosis in young teen-age girls","author":"Huffman","year":"1981","journal-title":"Pediatr Ann"},{"key":"key-10.4103\/0974-2727.66699-9","first-page":"245","volume-title":"Pathology of endometriosis","author":"Clement","year":"1990","journal-title":"Pathol Annu"},{"key":"key-10.4103\/0974-2727.66699-10","first-page":"235","volume-title":"Epidemiology of endometriosis","author":"Eskenazi","year":"1997","journal-title":"Obstet Gynecol Clin North Am"},{"key":"key-10.4103\/0974-2727.66699-11","first-page":"1759","volume-title":"Endometriosis","author":"Olive","year":"1993","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0974-2727.66699-12","first-page":"453","volume-title":"Endometriosis: current management","author":"Lu","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"key-10.4103\/0974-2727.66699-13","first-page":"132","volume-title":"Animal studies in endometriosis: a review","author":"Story","year":"2004","journal-title":"ILAR J"},{"key":"key-10.4103\/0974-2727.66699-14","first-page":"1753","volume-title":"Diagnosis and treatment of endometriosis","author":"Wellbery","year":"1999","journal-title":"Am Fam Physician"},{"key":"key-10.4103\/0974-2727.66699-15","first-page":"1070","volume-title":"Endometriosis and organochlorinated environmental pollutants: a case-control study on Italian women of reproductive age","author":"Porpora","year":"2009","journal-title":"Environ Health Perspect"},{"key":"key-10.4103\/0974-2727.66699-16","first-page":"161","volume-title":"Environmental dioxins and endometriosis","author":"Rier","year":"2002","journal-title":"Toxicol Sci"},{"key":"key-10.4103\/0974-2727.66699-17","first-page":"927","volume-title":"Expression of Annexin-1 in patients with endometriosis","author":"Li","year":"2008","journal-title":"Chin Med J"},{"key":"key-10.4103\/0974-2727.66699-18","first-page":"395","volume-title":"Possible aggravating impact of gene polymorphism in women with endometriosis","author":"Roya","year":"2009","journal-title":"Indian J Med Res"},{"key":"key-10.4103\/0974-2727.66699-19","unstructured":"American College of Obstetricians and Gynecologists. 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