{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:38:07Z","timestamp":1789907887732,"version":"4.0.1"},"reference-count":51,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":3499,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Brucellosis is a zoonotic infection transmitted from animals to humans by the ingestion of infected food products, direct contact with an infected animal or inhalation of aerosols. The last method is remarkably efficient given the relatively low concentration of organisms (10 \u2013 100 bacteria) needed to establish infection in humans, and has brought renewed attention to this old disease. Brucella is a facultative intracellular pathogen that has the ability to survive and multiply in the phagocytes and cause abortion in cattle and undulant fever in humans. Brucella spp particularly B. melitensis, B. abortus, and B. suis represent a significant public health concern. At present, B. melitensis is the principle cause of human brucellosis in India. Molecular studies have demonstrated the phylogenetic affiliation of Brucella to Agrobacterium, Ochrobactrum, and Rhizobium. Human brucellosis still presents scientists and clinicians with several challenges, with regard to the understanding of its pathogenic mechanism, severity, progression, and development of improved treatment regimens. Molecular studies have now highlighted the pathogenesis of Brucella, for the development of newer diagnostic tools that will be useful in developing countries where brucellosis is a common, but often a neglected disease. This review compiles all these issues in general and the pathogenicity and newer diagnostic tools in particular.<\/jats:p>","DOI":"10.4103\/0974-2727.72149","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T06:08:35Z","timestamp":1288332515000},"page":"055-060","source":"Crossref","is-referenced-by-count":106,"title":["Brucellosis: Review on the Recent Trends in Pathogenicity and Laboratory Diagnosis"],"prefix":"10.25259","volume":"2","author":[{"given":"Supriya","family":"Christopher","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kempegowda Institute of Medical Sciences, BSK II Stage, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umapathy B","family":"L.","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kempegowda Institute of Medical Sciences, BSK II Stage, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravikumar K","family":"L.","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kempegowda Institute of Medical Sciences, BSK II Stage, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"key-10.4103\/0974-2727.72149-1","first-page":"1270","volume-title":"Brucellosis- new aspects of an old disease","author":"Cultuer","year":"2005","journal-title":"J Appl Microbiol"},{"key":"key-10.4103\/0974-2727.72149-2","first-page":"125","volume-title":"The etiology of epizootic abortion","author":"Bang","year":"1897","journal-title":"J Comp Pathol Therap"},{"key":"key-10.4103\/0974-2727.72149-3","first-page":"539","volume-title":"Brucellosis in India","author":"Mantur","year":"2008","journal-title":"J Biosci"},{"key":"key-10.4103\/0974-2727.72149-4","unstructured":"Umapathy BL, Nagamani M, Bhat P, Keshavamurthy BS. Seroepidemiological studies on human brucellosis in and around Bangalore. Indian J Comp Microbiol Immunol Infect Dis 1984;5:83-7"},{"key":"key-10.4103\/0974-2727.72149-5","first-page":"313","volume-title":"From the discovery of the Malta fever\u2032s agent to the discovery ofa marine mammal reservoir, brucellosis has continuously been re-emerging zoonosis","author":"Godfroid","year":"2005","journal-title":"Vet Res"},{"key":"key-10.4103\/0974-2727.72149-6","doi-asserted-by":"crossref","unstructured":"Madkour MM, Madkoure. Brucellosis. New York: Springer Verlag; 2001. p. 11.","DOI":"10.1007\/978-3-642-59533-2"},{"key":"key-10.4103\/0974-2727.72149-7","first-page":"91","volume-title":"The new global map of human brucellosis","author":"Pappas","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"key-10.4103\/0974-2727.72149-8","first-page":"152","volume-title":"Serology, clinical manifestations and treatment of brucellosis","author":"Colmenero","year":"1990","journal-title":"Infection"},{"key":"key-10.4103\/0974-2727.72149-9","first-page":"59","volume-title":"Brucella bacteremia: clinical and laboratory observations in 160 patients","author":"Memish","year":"2000","journal-title":"J Infect Dis"},{"key":"key-10.4103\/0974-2727.72149-10","first-page":"3569","volume-title":"Brucella.abortus 16Sr RNA and lipid A reveal a phylogenetic relationship with members of the \u03b1 2 subdivision of the class proteobacteria","author":"Morenoe","year":"1990","journal-title":"J Bacteriol"},{"key":"key-10.4103\/0974-2727.72149-11","unstructured":"Corbel MJ, Brinley Morgan WJ. 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