{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:13:06Z","timestamp":1787062386663,"version":"build-2736575974"},"reference-count":9,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":3499,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polycythemia vera (PV) is a stem cell disorder, characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. Several reasons suggest that a mutation on the Janus kinase-2 gene (JAK2) is the most probable candidate gene involved in PV pathogenesis, as JAK2 is directly involved in intracellular signaling, following its exposure to cytokines, to which PV progenitor cells display hypersensitivity. A recurrent unique acquired clonal mutation in JAK2 was found in most patients with PV and other myeloproliferative diseases (MPDs). A female patient of age 50 years, presented with hemiplegia, diplopia, and had a consistent rise in hemoglobin and hematocrit. Serum Erythropoietin (Epo) was decreased. JAK2 mutation analysis was found to be negative. A diagnosis of polycythemia vera was made on the basis of the British Committee for Standards in Hematology (BCSH) guidelines.<\/jats:p>","DOI":"10.4103\/0974-2727.72215","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T02:08:35Z","timestamp":1288318115000},"page":"114-116","source":"Crossref","is-referenced-by-count":10,"title":["JAK2 Negative Polycythemia Vera"],"prefix":"10.25259","volume":"2","author":[{"given":"Geetha J","family":"P.","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arathi C","family":"A.","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"M.","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sri Siddhartha Medical College, Tumkur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa Murthy A","family":"G.","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sri Siddhartha Medical College, Tumkur, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"key-10.4103\/0974-2727.72215-1","first-page":"206","volume-title":"Polycythemia vera: Scientific advances and current practice","author":"Tefferi","year":"2005","journal-title":"Semin Hematol"},{"key":"key-10.4103\/0974-2727.72215-2","first-page":"599","volume-title":"Evaluation of increased hemoglobin in the JAK2 mutations era: A diagnostic algorithm based on genetic tests","author":"Tefferi","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"key-10.4103\/0974-2727.72215-3","first-page":"459","volume-title":"JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis","author":"Scott","year":"2007","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0974-2727.72215-4","first-page":"447","volume-title":"The classification and diagnosis of erythrocytosis","author":"McMullin","year":"2008","journal-title":"Int J Lab Hematol"},{"key":"key-10.4103\/0974-2727.72215-5","unstructured":"Spivak JL. Polycytemia vera and other myeloproliferative disorders. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. Harrison`s Principles of Internal Medicine. 17 th ed. United States of America: MacGraw-Hill companies; 2008. p. 672-3."},{"key":"key-10.4103\/0974-2727.72215-6","first-page":"1686","volume-title":"Somatic mutations of JAK2 exon 12 in patients with JAK2 (V617F)-negative myeloproliferative disorders","author":"Pietra","year":"2008","journal-title":"Blood"},{"key":"key-10.4103\/0974-2727.72215-7","first-page":"821","volume-title":"Amendement to the guideline for diagnosis and investigation of polycythemia\/erythrocytosis","author":"McMullin","year":"2007","journal-title":"Br J Haematol"},{"key":"key-10.4103\/0974-2727.72215-8","first-page":"123","volume-title":"Comparison of diagnostic criteria for polycythemia vera","author":"Turkington","year":"2007","journal-title":"Hematology"},{"key":"key-10.4103\/0974-2727.72215-9","first-page":"89","volume-title":"Pathogenetic role of JAK2 V617F mutation in chronic myeloproliferative disorders","author":"Hsu","year":"2007","journal-title":"J Chin Med Assoc"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0974-2727.72215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T03:18:38Z","timestamp":1703387918000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/jak2-negative-polycythemia-vera\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":9,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,1,29]]},"published-print":{"date-parts":[[2010,7]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2727.72215","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"value":"0974-2727","type":"print"},{"value":"0974-7826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}