{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:47:03Z","timestamp":1760122023514},"reference-count":10,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":3315,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Background: Patients with 1-5 skin lesions are clinically categorized as paucibacillary for treatment purposes. For betterment and adequate treatment of patients, this grouping needs further study.<\/jats:p><jats:p>\n          Aim: To study a group of leprosy patients with 1-5 skin lesions, compare clinical details with histopathological findings and bacteriological status of the skin to evaluate the relevance of this grouping.<\/jats:p><jats:p>\n          Materials and Methods: Two-year study involving  31 patients of leprosy with 1-5 skin lesions was included in this study. A number of skin lesions were recorded. Skin biopsies were taken in all patients. The biopsies were evaluated for the type of pathology and acid fast bacilli (AFB) status.<\/jats:p><jats:p>\n          Results: Of 31 patients, 19 (61.2%) had single skin lesion, 7 (22.5%) had two lesions, 4 (12.9%) had three lesions, and only one (3.22%) had four lesions, there were no patients with five lesions. Of the 31 patients, 30 (96.7%) were clinically diagnosed as borderline tuberculoid and one patient (3.22%) has tuberculoid leprosy. Skin smears were negative for AFB in all patients. The histological diagnoses were: TT 1 (3.22%), BT 24 (77.41%), and IL 6 (19.2%). AFB were found in 2 (6.45%) out of 31 skin biopsies. Clinicopathological correlation was 76.6% in the BT group.<\/jats:p><jats:p>\n          Conclusion: Tissue biopsy findings in 1-5 skin lesions which were not considered relevant for treatment purposes until now should be given a status in the categorization and assessment of severity of the disease. The significance of finding of AFB and histopathology of multibacillary (MB) type of leprosy in tissue biopsies, in patients grouped as PB should be resolved so that patients could be given the drug therapy and duration of therapy they warrant.<\/jats:p>","DOI":"10.4103\/0974-2727.78557","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T14:36:42Z","timestamp":1304692602000},"page":"021-024","source":"Crossref","is-referenced-by-count":2,"title":["Significance of Histopathology in Leprosy Patients with 1\u20135 Skin Lesions with Relevance to Therapy"],"prefix":"10.25259","volume":"3","author":[{"given":"S","family":"Veena","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology, J.J.M. Medical College, Davangere Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashikala","family":"P.","sequence":"additional","affiliation":[{"name":"Department of Dermatology, J.J.M. Medical College, Davangere, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurubasavaraj","family":"H.","sequence":"additional","affiliation":[{"name":"Department of Pathology, J.J.M. Medical College, Davangere Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H R","family":"Chandrasekhar","sequence":"additional","affiliation":[{"name":"Department of Pathology, J.J.M. Medical College, Davangere Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Murugesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"key-10.4103\/0974-2727.78557-1","unstructured":"WHO expert committee on leprosy, seventh report, WHO technical report series. WHO: Geneva; 1998. p. 874."},{"key":"key-10.4103\/0974-2727.78557-2","first-page":"17","volume-title":"Trends in detection of new leprosy cases at two centres in Himachal Pradesh, India: a ten-year study","author":"Mahajan","year":"2003","journal-title":"Indian J Lepr"},{"key":"key-10.4103\/0974-2727.78557-3","unstructured":"National Leprosy Eradication Programme Chattisgarh. Directorate of Health services (Leprosy cell.) Status report; 2004."},{"key":"key-10.4103\/0974-2727.78557-4","first-page":"435","volume-title":"A clinical and pathological study of macular lesions in leprosy","author":"Kar","year":"1994","journal-title":"Indian J Lepr"},{"key":"key-10.4103\/0974-2727.78557-5","first-page":"202","volume-title":"Correlation of clinical and histopathologic features in untreated macular lesions of leprosy - a study of 100 cases","author":"Shenoi","year":"1988","journal-title":"Indian J Lepr"},{"key":"key-10.4103\/0974-2727.78557-6","first-page":"177","volume-title":"Comparative histology of skin and nerve granulomas in leprosy patients","author":"Mukherjee","year":"1988","journal-title":"Lepr Rev"},{"key":"key-10.4103\/0974-2727.78557-7","first-page":"28","volume-title":"The role of nerve biopsies in diagnosis and management of leprosy","author":"Nilsen","year":"1989","journal-title":"Lepr Rev"},{"key":"key-10.4103\/0974-2727.78557-8","first-page":"329","volume-title":"Persistence of Mycobacterium leprae in peripheral nerves as compared to skin in multidrug treated leprosy patients","author":"Shetty","year":"1992","journal-title":"Lepr Rev"},{"key":"key-10.4103\/0974-2727.78557-9","first-page":"182","volume-title":"Why relapse occurs in PB leprosy patients after adequate MDT despite they are Mitsuda reactive: lessons form convit\u2032s experiment on bacteria clearing capacity of lepromin induced granuloma","author":"Chaudhuri","year":"1998","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"key-10.4103\/0974-2727.78557-10","first-page":"207","volume-title":"Evaluation of leprosy patients with 1-5 skin lesions with relevance to their grouping into PB or MB disease","author":"Rao","year":"2006","journal-title":"Indian J Dermatol Venereol Leprol","ISSN":"http:\/\/id.crossref.org\/issn\/0378-6323","issn-type":"print"}],"container-title":["Journal of Laboratory Physicians"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0974-2727.78557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T08:18:05Z","timestamp":1703405885000},"score":1,"resource":{"primary":{"URL":"https:\/\/jlabphy.org\/significance-of-histopathology-in-leprosy-patients-with-1-5-skin-lesions-with-relevance-to-therapy\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":10,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,29]]},"published-print":{"date-parts":[[2011,1]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2727.78557","relation":{},"ISSN":["0974-2727","0974-7826"],"issn-type":[{"type":"print","value":"0974-2727"},{"type":"electronic","value":"0974-7826"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}