{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:12Z","timestamp":1787840412351,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Trichotillomania is as medical condition caused by the patient himself by pulling out of is own hair, resulting in a perceptible hair loss pattern that frequently is associated with other psychiatric processes. Generally has a chronic course in most patients, and a challenging therapeutical management. There are several available options for is treatment, but the clinical response is not satisfactory in many patients. Recently, N-acetylcisteine, a glutamate modulator, has shown efficacy in the treatment of trichotillomania and other compulsive behaviors, and is considered a new alternative in the management of this condition. We describe two patients with trichotillomania successfully treated with N-acetylcysteine. Nevertheless, further studies need to be conducted to establish the appropriate treatment regimen and to evaluate it long-term efficacy in improving this chronic condition.<\/jats:p>","DOI":"10.4103\/0974-7753.100090","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T02:25:20Z","timestamp":1391048720000},"page":"176-178","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":52,"title":["N-acetylcysteine in the Treatment of Trichotillomania"],"prefix":"10.4103","volume":"4","author":[{"given":"Ana Rita","family":"Rodrigues-Barata","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Hospital Universitario Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Tosti","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rodr\u00edguez-Pichardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Hospital Universitario Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Camacho-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Hospital Universitario Virgen Macarena, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250606","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1001\/archgenpsychiatry.2009.60","article-title":"N-acetylcysteine, a glutamate modulator in the treatment of trichotillomania","volume":"66","author":"Grant","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"R2-20250606","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/ebm.13.3.66","article-title":"Practice corner: managing trichotillomania \u2013 no need to pull your hair out","volume":"13","author":"Papazisis","year":"2008","journal-title":"Evid Based Med"},{"key":"R3-20250606","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1067\/mjd.2002.122749","article-title":"Trichotillomania","volume":"46","author":"Hautmann","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"R4-20250606","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biopsych.2007.05.019","article-title":"Systematic review: Pharmacological and behavioral treatment for trichotillomania","volume":"62","author":"Bloch","year":"2007","journal-title":"Biol Psychiatry"},{"key":"R5-20250606","first-page":"123","article-title":"Low-dose pimozide augmentation of serotonin reuptake blockers in the treatment of trichotillomania","volume":"53","author":"Stein","year":"1992","journal-title":"J Clin Psychiatry"},{"key":"R6-20250606","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1089\/cap.2006.0111","article-title":"An open-label pilot study of naltrexone in childhood-onset trichotillomania","volume":"18","author":"De Sousa","year":"2008","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"R7-20250606","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/01.jcp.0000264976.86990.00","article-title":"N-acetyl cysteine in the treatment of grooming disorders","volume":"27","author":"Odlaug","year":"2007","journal-title":"J Clin Psychopharmacol"}],"container-title":["International Journal of Trichology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01437809-201204030-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:10Z","timestamp":1787836930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01437809-201204030-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-7753.100090","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717967438.793467207","asserted-by":"object"}]},"ISSN":["0974-7753","0974-9241"],"issn-type":[{"value":"0974-7753","type":"print"},{"value":"0974-9241","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}