{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:31:46Z","timestamp":1793406706922,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alopecia areata (AA) is a common, non-scarring, patchy loss of hair at scalp and elsewhere. Its pathogenesis is uncertain; however, auto-immunity has been exemplified in various studies. Familial incidence of AA is 10-42%, but in monozygotic twins is 50%. Local steroids (topical \/ intra-lesional) are very effective in treatment of localized AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To compare hair regrowth and side effects of topical betamethasone valerate foam, intralesional triamcinolone acetonide and tacrolimus ointment in management of localized AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>105 patients of localized AA were initially registered but 27 were drop out. So, 78 patients allocated at random in group A (28), B (25) and C (25) were prescribed topical betamethasone valerate foam (0.1%) twice daily, intralesional triamcinolone acetonide (10mg\/ml) every 3 weeks and tacrolimus ointment (0.1%) twice daily, respectively, for 12 weeks. They were followed for next12 weeks. Hair re-growth was calculated using \u201cHRG Scale\u201d; scale I- (0-25%), S II-(26-50%), S III - (51-75%) and S IV- (75-100%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Hair re-growth started by 3 weeks in group B (Scale I:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.03), turned satisfactory at 6 weeks in group A and B (Scale I:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.005, Scale IV:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001)), good at 9 weeks (Scale I:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0005, Scale IV:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.00015), and better by 12 weeks of treatment (Scale I:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.000021, Scale IV:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.000009) in both A and B groups. At the end of 12 weeks follow-up hair re-growth (&gt;75%, HRG IV) was the best in group B (15 of 25, 60%), followed by A (15 of 28, 53.6%) and lastly group-C (Nil of 25, 0%) patients. Few patients reported mild pain and atrophy at injection sites, pruritus and burning with betamethasone valerate foam and tacrolimus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Intralesional triamcinolone acetonide is the best, betamethasone valerate foam is better than tacrolimus in management of localized AA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0974-7753.82123","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T08:24:41Z","timestamp":1308299081000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":54,"title":["Randomized Comparison of Topical Betamethasone Valerate Foam, Intralesional Triamcinolone Acetonide and Tacrolimus Ointment in Management of Localized Alopecia Areata"],"prefix":"10.4103","volume":"3","author":[{"given":"CM","family":"Kuldeep","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Khare","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asit","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit K","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubhav","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260605","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1136\/bmj.2.4691.1250","article-title":"Alopecia areata: A clinical study","volume":"2","author":"Anderson","year":"1950","journal-title":"Br Med J"},{"key":"R3-20260605","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-4362.1996.tb01610.x","article-title":"Profile of alopecia areata in Northern India","volume":"35","author":"Sharma","year":"1996","journal-title":"Int J Dermatol"},{"key":"R4-20260605","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archderm.1992.01680150136027","article-title":"Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey","volume":"128","author":"Safavi","year":"1992","journal-title":"Arch Dermatol"},{"key":"R5-20260605","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2340\/0001555572373375","article-title":"The genetic risk for alopecia areata in first degree relatives of severely affected patients. 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