{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:31:45Z","timestamp":1787758305405,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bacterial infections remain an important cause of pediatric mortality and morbidity. It might be possible to reduce these factors by early diagnosis and proper management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of the study was to analyze the bacteriological profiles with their antibiogram, and to register the risk factors for septicemia in neonates and infants. Setting and design: This observational cross-sectional study was conducted in a tertiary care teaching hospital at Gangtok, Sikkim, India, and included clinically suspected cases of septicemia in neonates and infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Blood culture reports were studied in 363 cases of clinically suspected septicemia in neonates and infants, using the standard technique of Mackie and McCartney. The antibiotic sensitivity was performed by Kirby-Bauer's disc diffusion method. Risk factors for sepsis in the children were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Blood culture was positive in 22% of cases. Gram-negative septicemia was encountered in 61% of the culture-positive cases.\n                      <jats:italic toggle=\"yes\">Pseudomonas<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Enterobacter<\/jats:italic>\n                      species were the predominant pathogens amongst gram-negative organisms. Most gram-negative organisms were sensitive to Amikacin, Ciprofloxacin, and Co-trimoxazole. The most common gram-positive organism isolated was\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (97%). More than 70% of Staphylococci isolated were resistant to Penicillin, but were sensitive to Clindamycin (70%) and Vancomycin (40%). The most important risk factors of septicemia in our study population were preterm birth (31%), followed by respiratory distress (5%) and low birth weight (4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>As the cultures showed variable antibiogram with complicated patterns of resistance, culture and sensitivity test should be performed in all cases of septicemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0974-777x.77295","type":"journal-article","created":{"date-parts":[[2011,3,5]],"date-time":"2011-03-05T09:48:21Z","timestamp":1299318501000},"page":"42-45","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Bacteriological Profile of Septicemia and the Risk Factors in Neonates and Infants in Sikkim"],"prefix":"10.4103","volume":"3","author":[{"given":"Dechen C","family":"Tsering","sequence":"first","affiliation":[{"name":"Department of Microbiology, Sikkim Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital(CRH), Gangtok, Sikkim, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Chanchal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sikkim Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital(CRH), Gangtok, Sikkim, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranabir","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Sikkim Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital(CRH), Gangtok, Sikkim, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Sikkim Manipal Institute of Medical Sciences (SMIMS) and Central Referral Hospital(CRH), Gangtok, Sikkim, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260605","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1440-1754.1996.tb02565.x","article-title":"Neonatal bacterial sepsis in a neonatal intensive care unit: A 5 year analysis","volume":"32","author":"Sanghvi","year":"1996","journal-title":"J Paediatr Child Health"},{"key":"R2-20260605","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/INF.0b013e3181958769","article-title":"Pathogens associated with sepsis in newborns and young infants in developing countries","volume":"28","author":"Zaidi","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"R3-20260605","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2334-5-110","article-title":"Bacterial isolates from blood cultures of children with suspected septicemia in Calabar, 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Yale","volume":"13","author":"Freedam","year":"1981","journal-title":"Am J Dis Child"},{"key":"R13-20260605","first-page":"443","article-title":"A critical analysis of septicemia in infancy","volume":"13","author":"Somu","year":"1976","journal-title":"Indian Pediatr"},{"key":"R14-20260605","first-page":"519","article-title":"Prognosis and the treatment of neonatal septicemia: A clinicobacterial study of 100 cases","volume":"11","author":"Bhakoo","year":"1974","journal-title":"Indian Pediatr"},{"key":"R15-20260605","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12098-008-0056-z","article-title":"Sepsis in the newborn","volume":"75","author":"Sankar","year":"2008","journal-title":"Indian J Pediatr"}],"container-title":["Journal of Global Infectious 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