{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:31:14Z","timestamp":1787776274769,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    A detailed ocular examination and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    confocal microscopy (IVCM) using the Heidelberg retinal tomograph 3 with Rostock cornea module were performed in a patient with multiple endocrine neoplasia (MEN) 2b syndrome. Ocular findings included ptosis secondary to thickening of the lid margins, subconjunctival and perilimbal neuromas, and prominent corneal nerves extending up to the pupillary area. IVCM demonstrated structural alterations of both the main nerve trunks and the smaller branches. The main nerve trunks were grossly thickened while the smaller fibers were present in an intertwining manner in the anterior stroma. Some fibers showed prominent looping and nodular dilatations at irregular intervals along the length of the nerves. These nodular dilatations were in all probability ganglioneuromas of corneal nerves demonstrated by histopathology in earlier reports of MEN 2b. IVCM may be potentially useful in detecting the nerve alterations in MEN 2b even before other ocular or systemic features become apparent clinically.\n                  <\/jats:p>","DOI":"10.4103\/0974-9233.194094","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T08:24:11Z","timestamp":1485246251000},"page":"326-328","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["In Vivo Confocal Microscopic Architecture of Corneal Nerves in a Case of Multiple Endocrine Neoplasia Type 2b"],"prefix":"10.4103","volume":"23","author":[{"given":"Chintan","family":"Malhotra","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikram","family":"Thapa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabin","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250523","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1530\/eje.0.1370572","article-title":"Multiple endocrine neoplasia type 2: Recent progress in diagnosis and management","volume":"137","author":"Heshmati","year":"1997","journal-title":"Eur J Endocrinol"},{"key":"R2-20250523","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3928\/01913913-20090616-11","article-title":"Diffuse corneoscleral limbal neuromas with prominent corneal nerves in multiple endocrine neoplasia syndrome type IIB","volume":"47","author":"Puvanachandra","year":"2010","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"R3-20250523","first-page":"176","article-title":"Confocal scan imaging and impression cytology of the cornea in a case of multiple endocrine neoplasia type-2b","volume":"7","author":"Javadi","year":"2012","journal-title":"J Ophthalmic Vis Res"},{"key":"R4-20250523","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00002341-200105000-00009","article-title":"From eyelid bumps to thyroid lumps: Report of a MEN type IIb family and review of the literature","volume":"17","author":"Jacobs","year":"2001","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"R5-20250523","first-page":"1","article-title":"Corneal nerves","volume":"19","author":"Mensher","year":"1974","journal-title":"Surv Ophthalmol"},{"key":"R6-20250523","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0002-9394(40)92522-3","article-title":"Bilateral plexiform neurofibromata of the conjunctiva and medullated corneal nerves","volume":"23","author":"Koke","year":"1940","journal-title":"Am J Ophthalmol"},{"key":"R7-20250523","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1442-9071.1995.tb00189.x","article-title":"Multiple endocrine neoplasia type two B. A case report with light and electron microscopic and immunohistochemical correlation","volume":"23","author":"Koh","year":"1995","journal-title":"Aust N Z J Ophthalmol"}],"container-title":["Middle East African Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01436644-201623040-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:04:51Z","timestamp":1787774691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01436644-201623040-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-9233.194094","relation":{},"ISSN":["0974-9233","0975-1599"],"issn-type":[{"value":"0974-9233","type":"print"},{"value":"0975-1599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]}}}