{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:44:14Z","timestamp":1791067454973,"version":"4.1.0"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Natl J Maxillofac Surg"],"published-print":{"date-parts":[[2013]]},"DOI":"10.4103\/0975-5950.127643","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T06:30:50Z","timestamp":1392877850000},"page":"151","source":"Crossref","is-referenced-by-count":23,"title":["Bisphophonates related osteonecrosis of the jaw"],"prefix":"10.4103","volume":"4","author":[{"given":"Swati","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra","family":"Mandhyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0975-5950.127643-1","first-page":"571","volume-title":"Bisphosphonate mechanism of action","author":"Rodan","year":"2002","journal-title":"Curr Mol Med"},{"key":"key-10.4103\/0975-5950.127643-2","first-page":"558","volume-title":"Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials","author":"Major","year":"2001","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/0975-5950.127643-3","unstructured":"Available from: http:\/\/www.out\/our_organisation www.medicareaustralia.gov.au\/ab\/annual report\/03-04\/statistics.htm#2. [Last accessed on 2005 Nov 26]."},{"key":"key-10.4103\/0975-5950.127643-4","first-page":"1115","volume-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-5","first-page":"2","volume-title":"Bisphosphonate-related osteonecrosis of the jaws","author":"Ruggiero","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-6","first-page":"1658","volume-title":"Managing the care of patients with bisphosphonate-associated osteonecrosis: An American Academy of Oral Medicine position paper","author":"Migliorati","year":"2005","journal-title":"J Am Dent Assoc"},{"key":"key-10.4103\/0975-5950.127643-7","first-page":"S4","volume-title":"The dental implications of bisphosphonates and bone disease","author":"Cheng","year":"2005","journal-title":"Aust Dent J"},{"key":"key-10.4103\/0975-5950.127643-8","first-page":"30","volume-title":"Development of bisphosphonates","author":"Fleisch","year":"2002","journal-title":"Breast Cancer Res"},{"key":"key-10.4103\/0975-5950.127643-9","first-page":"2016","volume-title":"Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats","author":"Little","year":"2003","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/0975-5950.127643-10","first-page":"19","volume-title":"Systemic alendronate prevents resorption of necrotic bone during revascularization.A bone chamber study in rats","author":"Astrand","year":"2002","journal-title":"BMC Musculoskelet Disord"},{"key":"key-10.4103\/0975-5950.127643-11","first-page":"130","volume-title":"Bisphosphonates-mechanisms of action","author":"Martin","year":"2000","journal-title":"Aust Prescriber"},{"key":"key-10.4103\/0975-5950.127643-12","first-page":"206","volume-title":"Bisphosphonates in bone diseases","author":"Sparidans","year":"1998","journal-title":"Pharm World Sci"},{"key":"key-10.4103\/0975-5950.127643-13","first-page":"80","volume-title":"Bisphosphonates: Mechanisms of action","author":"Fleisch","year":"1998","journal-title":"Endocr Rev"},{"key":"key-10.4103\/0975-5950.127643-14","first-page":"1479","volume-title":"American Society for Bone and Mineral Research.Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research","author":"Khosla","year":"2007","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/0975-5950.127643-15","first-page":"365","volume-title":"Bisphosphonate-related osteonecrosis of the jaw: Position paper from the Allied Task Force Committee of Japanese Society for Bone and Mineral Research, Japan Osteoporosis Society, Japanese Society of Periodontology, Japanese Society for Oral and Maxillofacial Radiology, and Japanese Society of Oral and Maxillofacial Surgeons","author":"Yoneda","year":"2010","journal-title":"J Bone Miner Metab"},{"key":"key-10.4103\/0975-5950.127643-16","first-page":"1144","volume-title":"Dental management of patients receiving oral bisphosphonate therapy: Expert panel recommendations","author":"American","year":"2006","journal-title":"J Am Dent Assoc"},{"key":"key-10.4103\/0975-5950.127643-17","first-page":"1567","volume-title":"Bisphosphonate-induced exposure bone (osteonecrosis\/osteoporosis) of the jaws: Risk factors, recognition, prevention, and treatment","author":"Marx","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-18","first-page":"111","volume-title":"Osteonecrosis of the maxilla in a patient with a history of bisphosphonate therapy","author":"Melo","year":"2005","journal-title":"J Can Dent Assoc"},{"key":"key-10.4103\/0975-5950.127643-19","first-page":"841","volume-title":"Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis","author":"Rizzoli","year":"2008","journal-title":"Bone"},{"key":"key-10.4103\/0975-5950.127643-20","first-page":"2278","volume-title":"Osteonecrosis of the jaw -0 do bisphosphonates pose a risk?","author":"Bilezikian","year":"2006","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0975-5950.127643-21","first-page":"44","volume-title":"Intravenous bisphosphonate therapy and bisphosphonate-related osteonecrosis of the jaws","author":"Dodson","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-22","first-page":"71","volume-title":"Epidemiology of bisphosphonate-related osteonecrosis of the jaws: The utility of a national registry","author":"Gliklich","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-23","first-page":"271","volume-title":"Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: A possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings","author":"Hoefert","year":"2010","journal-title":"Clin Oral Investig"},{"key":"key-10.4103\/0975-5950.127643-24","first-page":"40","volume-title":"The role of microbial biofilms in osteonecrosis of the jaw associated with bisphosphonate therapy","author":"Kumar","year":"2010","journal-title":"Curr Osteoporos Rep"},{"key":"key-10.4103\/0975-5950.127643-25","first-page":"843","volume-title":"Bisphosphonate-associated osteonecrosis of the jaw: A key role of inflammation?","author":"Lesclous","year":"2009","journal-title":"Bone"},{"key":"key-10.4103\/0975-5950.127643-26","first-page":"4","volume-title":"Osteonecrosis of the jaw: Who gets it, and why?","author":"Reid","year":"2009","journal-title":"Bone"},{"key":"key-10.4103\/0975-5950.127643-27","first-page":"527","volume-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases","author":"Ruggiero","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-28","first-page":"S55","volume-title":"Osteonecrosis of the jaw in patients receiving intravenous bisphosphonates","author":"Hoff","year":"2005","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/0975-5950.127643-29","first-page":"767","volume-title":"Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy","author":"Sedghizadeh","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-30","first-page":"236","volume-title":"Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws","author":"Chiandussi","year":"2006","journal-title":"Dentomaxillofac Radiol"},{"key":"key-10.4103\/0975-5950.127643-31","first-page":"945","volume-title":"Ostonecrosis of the jaw in multiple myeloma patients: Clinical features and risk factors","author":"Badros","year":"2006","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/0975-5950.127643-32","first-page":"99","volume-title":"Osteonecrosis of the jaw and bisphosphonates","author":"Durie","year":"2005","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0975-5950.127643-33","doi-asserted-by":"crossref","unstructured":"Hoff AO, Toth BB, Altundag K, et al. Osteonecrosis of the jaw in patients receiving intravenous bisphosphonate therapy. J Clin Oncol 2006;24:8528. ASCO Annual Meeting Proceedings (post meeting edition). Available at: http:\/\/meeting.jco.org\/cgi\/content\/abstract\/24\/18_suppl\/8528.","DOI":"10.1200\/jco.2006.24.18_suppl.8528"},{"key":"key-10.4103\/0975-5950.127643-34","first-page":"1541","volume-title":"Risk of osteonecrosis of the jaw in cancer patients taking bisphosphonates","author":"Gebara","year":"2009","journal-title":"Am J Health Syst Pharm"},{"key":"key-10.4103\/0975-5950.127643-35","first-page":"625","volume-title":"Zoledronate, smoking, and obesity are strong risk factors for osteonecrosis of the jaw: A case-control study","author":"Wessel","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-36","first-page":"753","volume-title":"Narrative [corrected] review: Bisphosphonates and osteonecrosis of the jaws","author":"Woo","year":"2006","journal-title":"Ann Intern Med"},{"key":"key-10.4103\/0975-5950.127643-37","first-page":"2015","volume-title":"A retrospective study assessing the incidence, risk factors and comorbidities of pamidronate-related necrosis of the jaws in multiple myeloma patients","author":"Jadu","year":"2007","journal-title":"Ann Oncol"},{"key":"key-10.4103\/0975-5950.127643-38","first-page":"2709","volume-title":"Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: A genome-wide single nucleotide polymorphism analysis","author":"Sarasquate","year":"2008","journal-title":"Blood"},{"key":"key-10.4103\/0975-5950.127643-39","first-page":"473","volume-title":"Osteonecrosis of the jaws and bisphosphonate treatment in cancer patients","author":"Wutzl","year":"2006","journal-title":"Wien Klin Wochenschr"},{"key":"key-10.4103\/0975-5950.127643-40","first-page":"550","volume-title":"Energy metabolism of human neutrophils during phagocytosis","author":"Borregaard","year":"1982","journal-title":"J Clin Invest"},{"key":"key-10.4103\/0975-5950.127643-41","first-page":"146","volume-title":"Fluoride-18 scintigraphy in avascular necrotic disorders of bone","author":"D\u2032Ambrosia","year":"1975","journal-title":"Clin Orthop Relat Res"},{"key":"key-10.4103\/0975-5950.127643-42","first-page":"647","volume-title":"Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-[F-18]-fluoro-2-deoxy-D-glucose","author":"Palmer","year":"1995","journal-title":"Radiology"},{"key":"key-10.4103\/0975-5950.127643-43","first-page":"663","volume-title":"Vascularity of the femoral head: 18fluorine scintigraphy validated with tetracycline labeling","author":"Stadalnik","year":"1975","journal-title":"Radiology"},{"key":"key-10.4103\/0975-5950.127643-44","first-page":"31","volume-title":"Cone beam computed tomography in craniofacial imaging","author":"Sukovic","year":"2003","journal-title":"Orthod Craniofac Res"},{"key":"key-10.4103\/0975-5950.127643-45","first-page":"371","volume-title":"A comparison of a new limited cone beam computed tomography machine for dental use with a multidetector row helical CT machine","author":"Hashimoto","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"key-10.4103\/0975-5950.127643-46","first-page":"1","volume-title":"State-of-the-art on cone beam CT imaging for preoperative planning of implant placement","author":"Guerrero","year":"2006","journal-title":"Clin Oral Investig"},{"key":"key-10.4103\/0975-5950.127643-47","first-page":"232","volume-title":"Diagnostic criteria for the detection of mandibular osteomyelitis using cone-beam computed tomography","author":"Schulze","year":"2006","journal-title":"Dentomaxillofac Radiol"},{"key":"key-10.4103\/0975-5950.127643-48","first-page":"251","volume-title":"Diagnosis of osteomyelitis: Utility of fat-suppressed contrast-enhanced MR imaging","author":"Morrison","year":"1993","journal-title":"Radiology"},{"key":"key-10.4103\/0975-5950.127643-49","first-page":"1503","volume-title":"Osteonecrosis of the jaw: More research needed","author":"Shane","year":"2006","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/0975-5950.127643-50","doi-asserted-by":"crossref","unstructured":"AAE Special Committee on Bisphosphonates, editor. Endodontic Implications of Bisphosphonate-Associated Osteonecrosis of the Jaws. Chicago, IL: American Association of Endodontists; 2006.(not applicable)","DOI":"10.1016\/S0084-3717(08)70223-X"},{"key":"key-10.4103\/0975-5950.127643-51","unstructured":"Marx RE. Oral and intravenous bisphosphonate induced osteonecrosis of the jaws: History, etiology, prevention, and treatment. Hanover Park: Quintessence; 2006.(not applicable)"},{"key":"key-10.4103\/0975-5950.127643-52","first-page":"2397","volume-title":"Oral bisphosphonate-induced osteonecrosis: Risk factors, prediction of risk using serum CTX testing, prevention, and treatment","author":"Marx","year":"2007","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-53","unstructured":"American Association of Oral and Maxillofacial Surgeons. Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaw-2009. Available from: Update www.aaoms.org [Last accessed on 2009 Jan 30]."},{"key":"key-10.4103\/0975-5950.127643-54","first-page":"1088","volume-title":"Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates","author":"Bagan","year":"2008","journal-title":"Oral Oncol"},{"key":"key-10.4103\/0975-5950.127643-55","first-page":"181","volume-title":"Bisphosphonate-related osteonecrosis of the jaw (BRONJ) therapy.A critical review","author":"Vescovi","year":"2010","journal-title":"Minerva Stomatol"},{"key":"key-10.4103\/0975-5950.127643-56","first-page":"7","volume-title":"Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer","author":"Ruggiero","year":"2006","journal-title":"J Oncol Pract"},{"key":"key-10.4103\/0975-5950.127643-57","first-page":"61","volume-title":"Outcomes of bisphosphonate-related osteonecrosis of the jaw.Importance of staging and management guidelines: A large single institution update","author":"Mehrotra","year":"2008","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/0975-5950.127643-58","first-page":"83","volume-title":"Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: An emerging oral complication of supportive cancer therapy","author":"Migliorati","year":"2005","journal-title":"Cancer"},{"key":"key-10.4103\/0975-5950.127643-59","first-page":"1189","volume-title":"Alendronate Phase III Osteoporosis Treatment Study Group.Ten years\u2032 experience with alendronate for osteoporosis in postmenopausal women","author":"Bone","year":"2004","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0975-5950.127643-60","first-page":"327","volume-title":"Jaw osteonecrosis associated with bisphosphonates: Multiple exposed areas and its relationship to teeth extractions.Study of 20 cases","author":"Bagan","year":"2006","journal-title":"Oral Oncol"},{"key":"key-10.4103\/0975-5950.127643-61","first-page":"1100","volume-title":"Primary surgical therapy for osteonecrosis of the jaw secondary to bisphosphonate therapy","author":"Kademani","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"key-10.4103\/0975-5950.127643-62","first-page":"371","volume-title":"Use of platelet-rich plasma in the management of oral bisphosphonate-associated osteonecrosis of the jaw: A report of 2 cases","author":"Lee","year":"2007","journal-title":"J Oral Implantol"},{"key":"key-10.4103\/0975-5950.127643-63","first-page":"349","volume-title":"Safety of oral bisphosphonates: Controlled studies on alveolar bone","author":"Jeffcoat","year":"2006","journal-title":"Int J Oral Maxillofac Implants"},{"key":"key-10.4103\/0975-5950.127643-64","first-page":"584","volume-title":"Effect of long-term oral bisphosphonates on implant wound healing: Literature review and a case report","author":"Wang","year":"2007","journal-title":"J Periodontol"},{"key":"key-10.4103\/0975-5950.127643-65","first-page":"77","volume-title":"Osteonecrosis of the jaw may not be a common acute side-effect of oral bisphosphonates","author":"Migliorati","year":"2007","journal-title":"J Evid Base Dent Pract"},{"key":"key-10.4103\/0975-5950.127643-66","first-page":"223","volume-title":"Outcomes of placing dental implants in patients taking oral bisphosphonates: A review of 115 cases","author":"Grant","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-67","first-page":"1022","volume-title":"Oral bisphosphonates and dental implants: A retrospective study","author":"Bell","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/0975-5950.127643-68","first-page":"1664","volume-title":"Implant placement with or without simultaneous tooth extraction in patients taking oral bisphosphonates: Postoperative healing, early follow-up, and the incidence of complications in two private practices","author":"Fugazzotto","year":"2007","journal-title":"J Periodontol"},{"key":"key-10.4103\/0975-5950.127643-69","first-page":"e65","volume-title":"Dental implants in patients treated with oral bisphosphonates: A bibliographic review","author":"Montoya-Carraler","year":"2010","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"key-10.4103\/0975-5950.127643-70","first-page":"E318","volume-title":"Osteochemonecrosis of the jaws due to bisphosphonate treatments.Update","author":"G\u00f3mez","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"key-10.4103\/0975-5950.127643-71","first-page":"1148","volume-title":"A bisphosphonate-coating improves the fixation of metal implants in human bone.A randomized trial of dental implants","author":"Abtahi","year":"2012","journal-title":"Bone"},{"key":"key-10.4103\/0975-5950.127643-72","first-page":"10","volume-title":"Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model.A pilot study","author":"Stadelmann","year":"2008","journal-title":"Eur Cell Mater"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:19:12Z","timestamp":1786648752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0975-5950.127643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013]]}},"alternative-id":["127643"],"URL":"https:\/\/doi.org\/10.4103\/0975-5950.127643","relation":{},"ISSN":["0975-5950"],"issn-type":[{"value":"0975-5950","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}