{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:49:31Z","timestamp":1791888571475,"version":"4.3.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Head and neck cancer is a major health problem. Oral cancer is increasing in Indian subcontinent mainly due to lack of hygiene, tobacco use, chewing tobacco, smoking, and many other factors. Radiation therapy is the most common form of treatment along with surgery and chemotherapy. There are 2 types of complication that occurs during and after radiotherapy, that occur because of effects on normal tissue. Radiotherapy-induced effects occur on the oral mucosa salivary glands, bone, teeth, and musculature of face and neck. These complications needs special attention for their prevention and treatment, Preradiotherapy evaluation and disease stabilization are necessary in every patient, counseling of patients before during and after radiotherapy is important to help them become aware of several oral complications and their prevention.<\/jats:p>","DOI":"10.4103\/0975-5950.154812","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T02:22:03Z","timestamp":1428546123000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":77,"title":["Dental care during and after radiotherapy in head and neck cancer"],"prefix":"10.4103","volume":"5","author":[{"given":"Seema","family":"Devi","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, J. N. Medical College, AMU, Aligarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, K.G.Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s11912-004-0027-0","article-title":"Epigenetic alterations in head and neck cancer: Prevalence, clinical significance, and implications","volume":"6","author":"Fan","year":"2004","journal-title":"Curr Oncol Rep"},{"key":"R2-20250925","first-page":"305","article-title":"Primary head and neck cancers in North Eastern Nigeria","volume":"23","author":"Otoh","year":"2004","journal-title":"West Afr J Med"},{"key":"R4-20250925","first-page":"4779","article-title":"Head and neck cancer: A global perspective on epidemiology and prognosis","volume":"18","author":"Sankaranarayanan","year":"1998","journal-title":"Anticancer Res"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"316","DOI":"10.14219\/jada.archive.1987.0066","article-title":"Prevention and treatment of the orofacial complications of radiotherapy","volume":"114","author":"Rothwell","year":"1987","journal-title":"J Am Dent Assoc"},{"key":"R6-20250925","first-page":"36","article-title":"Oral complications in the head and neck radiation patient. Introduction and scope of the problem","volume":"10","author":"Specht","year":"2002","journal-title":"Support Care Cancer"},{"key":"R7-20250925","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1834-7819.2001.tb00562.x","article-title":"Dental complications of head and neck radiotherapy: Part 1","volume":"46","author":"Andrews","year":"2001","journal-title":"Aust Dent J"},{"key":"R8-20250925","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/(SICI)1097-0185(199806)253:3<70::AID-AR3>3.0.CO;2-I","article-title":"Biology of taste buds and the clinical problem of taste loss","volume":"253","author":"Nelson","year":"1998","journal-title":"Anat Rec"},{"key":"R9-20250925","first-page":"1767","article-title":"Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management","volume":"17","author":"Epstein","year":"2003","journal-title":"Oncology (Williston Park)"},{"key":"R11-20250925","first-page":"585","article-title":"Oral and dental management related to radiation therapy for head and neck cancer","volume":"69","author":"Hancock","year":"2003","journal-title":"J Can Dent Assoc"},{"key":"R12-20250925","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1177\/00220345750540040801","article-title":"Effect of radiation-induced xerostomia on human oral microflora","volume":"54","author":"Brown","year":"1975","journal-title":"J Dent Res"},{"key":"R13-20250925","doi-asserted-by":"crossref","first-page":"843","DOI":"10.4103\/0970-9290.111293","article-title":"Radiotherapy complications and their possible management in the head and neck region","volume":"23","author":"Agarwal","year":"2012","journal-title":"Indian J Dent Res"},{"key":"R14-20250925","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0011-8532(22)01144-2","article-title":"Oral tissue changes of radiation-oncology and their management","volume":"34","author":"Fleming","year":"1990","journal-title":"Dent Clin North Am"},{"key":"R15-20250925","first-page":"64","article-title":"Taste dysfunction in irradiated patients with head and neck cancer","volume":"93","author":"Zheng","year":"2002","journal-title":"Fukuoka Igaku Zasshi"},{"key":"R16-20250925","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/(SICI)1097-0142(19980515)82:10<1938::AID-CNCR18>3.0.CO;2-U","article-title":"A randomized, controlled clinical trial to evaluate the effects of zinc sulfate on cancer patients with taste alterations caused by head and neck irradiation","volume":"82","author":"Ripamonti","year":"1998","journal-title":"Cancer"},{"key":"R17-20250925","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/hed.10129","article-title":"Patients with head and neck cancer cured by radiation therapy: A survey of the dry mouth syndrome in long-term survivors","volume":"24","author":"Wijers","year":"2002","journal-title":"Head Neck"},{"key":"R18-20250925","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0030-4220(87)90146-0","article-title":"Prevalence of caries-associated microflora after radiotherapy in patients with cancer of the head and neck","volume":"64","author":"Keene","year":"1987","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R19-20250925","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/1097-0142(197608)38:2<994::AID-CNCR2820380251>3.0.CO;2-B","article-title":"Dental management of patients irradiated for oral cancer","volume":"38","author":"Regezi","year":"1976","journal-title":"Cancer"},{"key":"R20-20250925","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/hed.20760","article-title":"Trismus in patients with oropharyngeal cancer: Relationship with dose in structures of mastication apparatus","volume":"30","author":"Teguh","year":"2008","journal-title":"Head Neck"},{"key":"R21-20250925","first-page":"1033","article-title":"A systematic review of trismus induced by cancer therapies in head and neck cancer patients","volume":"18","author":"Bensadoun","year":"2010","journal-title":"Support Care Cancer"},{"key":"R22-20250925","first-page":"45","article-title":"The use of a dynamic opening device in the treatment of radiation induced trismus","volume":"9","author":"Brunello","year":"1995","journal-title":"Aust Prosthodont J"},{"key":"R23-20250925","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2334\/josnusd.51.141","article-title":"Treating trismus with dynamic splinting: A case report","volume":"51","author":"Shulman","year":"2009","journal-title":"J Oral Sci"},{"key":"R24-20250925","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0360-3016(82)90166-3","article-title":"Long-term effects of radiotherapy on taste and salivary function in man","volume":"8","author":"Mossman","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R25-20250925","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/hed.2890010404","article-title":"Radiation therapy of the oral cavity: Sequelae and management, part 1","volume":"1","author":"Beumer","year":"1979","journal-title":"Head Neck Surg"},{"key":"R26-20250925","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1177\/0022034509343143","article-title":"Sensitivity of salivary glands to radiation: From animal models to therapies","volume":"88","author":"Grundmann","year":"2009","journal-title":"J Dent Res"},{"key":"R27-20250925","first-page":"87","article-title":"Oral complications of cancer therapies. Pretherapy interventions to modify salivary dysfunction","author":"Wolff","year":"1990","journal-title":"NCI Monogr"},{"key":"R28-20250925","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0360-3016(92)90023-B","article-title":"Devices valuable in head and neck radiotherapy","volume":"23","author":"Kaanders","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R29-20250925","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0278-2391(83)90294-X","article-title":"Osteoradionecrosis: A new concept of its pathophysiology","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"R30-20250925","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0278-2391(03)00669-4","article-title":"Dental extractions in the irradiated head and neck patient: A retrospective analysis of Memorial Sloan-Kettering Cancer Center protocols, criteria, and end results","volume":"61","author":"Sulaiman","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"R31-20250925","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/1097-0142(19810415)47:8<1980::AID-CNCR2820470813>3.0.CO;2-Y","article-title":"Osteonecrosis in patients irradiated for head and neck carcinoma","volume":"47","author":"Morrish","year":"1981","journal-title":"Cancer"},{"key":"R32-20250925","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ijrobp.2006.11.059","article-title":"Lack of osteoradionecrosis of the mandible after intensity-modulated radiotherapy for head and neck cancer: Likely contributions of both dental care and improved dose distributions","volume":"68","author":"Ben-David","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R33-20250925","first-page":"28","article-title":"Dental management of the head and neck cancer patients treated with radiation therapy","volume":"93","author":"Murdoch-Kinch","year":"2011","journal-title":"J Mich Dent Assoc"},{"key":"R34-20250925","doi-asserted-by":"crossref","first-page":"49","DOI":"10.14219\/jada.archive.1985.0074","article-title":"Prevention of osteoradionecrosis: A randomized prospective clinical trial of hyperbaric oxygen versus penicillin","volume":"111","author":"Marx","year":"1985","journal-title":"J Am Dent Assoc"},{"key":"R35-20250925","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/154411130301400306","article-title":"Prevention and treatment of the consequences of head and neck radiotherapy","volume":"14","author":"Vissink","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"key":"R36-20250925","first-page":"147","article-title":"Proceedings: The management of teeth related to the treatment of oral cancer","volume":"7","author":"Daly","year":"1972","journal-title":"Proc Natl Cancer Conf"},{"key":"R37-20250925","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000261173","article-title":"In vivo study on the prevention of postradiation caries","volume":"23","author":"Jansma","year":"1989","journal-title":"Caries Res"},{"key":"R39-20250925","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0360-3016(93)90143-J","article-title":"Major salivary gland function in patients with radiation-induced xerostomia: Flow rates and sialochemistry","volume":"25","author":"Valdez","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R41-20250925","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0901-5027(87)80031-0","article-title":"Dental extractions in relation to radiation therapy of 224 patients","volume":"16","author":"Makkonen","year":"1987","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01515625-201405020-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:39:57Z","timestamp":1787067597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01515625-201405020-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-5950.154812","relation":{},"ISSN":["0975-5950","2229-3418"],"issn-type":[{"value":"0975-5950","type":"print"},{"value":"2229-3418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}