{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:08Z","timestamp":1787071448765,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Gingival bleeding is considered as an important clinical sign for diagnosis of periodontal disease pathogenesis. Immune inflammatory reactions caused by local factors are considered as essential reasons for gingival bleeding, as also for the systemic bleeding disorders. In disease-free conditions of gingiva, the bleeding disorders are considered to be the main contender for bleeding. Other than these variables, many systemic drugs including systemic aspirin could also cause gingival bleeding. The main aim of the study was to evaluate the effect of buffered aspirin therapy on gingival bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Totally, 36 systemically healthy individuals were included in the 15-day randomized, double-blinded, placebo-controlled clinical trial. The 15 days were divided as: control period for the first 7 days and study period for the following 7 days. On the 1\n                      <jats:sup>st<\/jats:sup>\n                      day, all individuals were given oral prophylaxis after recording gingival parameters such as Plaque Index, probing depth, and Bleeding Index, and then blood samples were collected for hematological investigations. Then, all individuals were administered placebo capsules for 1 week as once daily dose. On the 8\n                      <jats:sup>th<\/jats:sup>\n                      day, all procedures were repeated and the individuals were prescribed with 325 coated aspirin capsules for 1 week. On the 15\n                      <jats:sup>th<\/jats:sup>\n                      day, all parameters were repeated and the results were statistically analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the study period, the parameters such as Bleeding Index, bleeding time, and prothrombin time were increased significantly, compared to the control period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The variables such as systemic drug therapy should be considered for the examination of gingiva while the diagnosis is considered mainly based on gingival bleeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.100210","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T02:19:46Z","timestamp":1391048386000},"page":"S221-S225","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Evaluative comparison of systemic aspirin therapy effects on gingival bleeding in post non-surgical periodontal therapy individuals"],"prefix":"10.4103","volume":"4","author":[{"given":"Elanchezhiyan","family":"Sundram","sequence":"first","affiliation":[{"name":"Department of Periodontia, KSR Inst of Dental Science and Research, Tiruchengode, Tamil Nadu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panishankar","family":"Kharaharilal","sequence":"additional","affiliation":[{"name":"Department of Periodontia, SRM Dental College, Kattankolatoor, Tamil Nadu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugumari","family":"Ilavarasu","sequence":"additional","affiliation":[{"name":"Department of Periodontia, JKK Natarajah Dental College, Komarapalayam, Tamil Nadu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Renukadevi","sequence":"additional","affiliation":[{"name":"JKK Natarajah Dental College, Komarapalayam, Tamil Nadu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Nalini","sequence":"additional","affiliation":[{"name":"JKK Natarajah Dental College, Komarapalayam, Tamil Nadu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venilla","family":"Karunamoorthy","sequence":"additional","affiliation":[{"name":"JKK Natarajah Dental College, Komarapalayam, Tamil Nadu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1600-051X.1990.tb01059.x","article-title":"Absence of bleeding on probing. 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