{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:04:14Z","timestamp":1790204654045,"version":"4.1.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>\n                    Periodontitis is an inflammatory disease of the supporting tissues of the teeth, caused by a group of specific microorganisms. Aggressive forms of periodontitis can be localized or generalized. The concept that localized problem sites may be treated by local drug delivery appears attractive as the antimicrobial agent is delivered within periodontal pockets and the therapy is targeted on specific pathogenic microorganisms. Periodontitis can result in bone resorption creating bony defects, which may cause tooth loss. Various drugs have been studied using local delivery to improve the periodontal health and to achieve periodontal regeneration. Local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction. Pharmacological agents offer great promise in this direction. Simvastatin, used for the treatment of hypercholesterolemia, is a universally accepted and relatively inexpensive drug. Local application of simvastatin has been shown to stimulate bone formation in rodents both\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and in human periodontal ligament cells\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    . This article reviews the effects of simvastatin as a local delivery and examines its potential role in periodontal regenerative therapy.\n                  <\/jats:p>","DOI":"10.4103\/0975-7406.100225","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T02:19:46Z","timestamp":1391048386000},"page":"S248-S251","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":30,"title":["Statins: A new era in local drug delivery"],"prefix":"10.4103","volume":"4","author":[{"given":"Sugumari","family":"Elavarasu","sequence":"first","affiliation":[{"name":"Department of Periodontics, JKK Nattaraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanga Kumaran","family":"Suthanthiran","sequence":"additional","affiliation":[{"name":"Department of Periodontics, JKK Nattaraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devisree","family":"Naveen","sequence":"additional","affiliation":[{"name":"Department of Periodontics, JKK Nattaraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1902\/jop.1993.64.8s.782","article-title":"Controlled release local delivery- Antimicrobials in Periodontics. Prospects for the future","volume":"64","author":"Kornman","year":"1993","journal-title":"J Periodontol"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0765.1991.tb02075.x","article-title":"Multicenter evaluation of tetracycline fiber therapy: I. Experimental design, methods, and baseline data","volume":"26","author":"Goodson","year":"1991","journal-title":"J Periodont Res"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-0757.1994.tb00022.x","article-title":"Antimicrobial strategies for treatment of periodontal diseases","volume":"2005","author":"Goodson","year":"1994","journal-title":"Periodontology"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-051X.1994.tb00293.x","article-title":"Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis","volume":"21","author":"Hitzig","year":"1994","journal-title":"Clin Perio"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1902\/jop.1992.63.2.73","article-title":"Minocycline slow release formulation effect on subgingival bacteria","volume":"63","author":"Okuda","year":"1992","journal-title":"J Periodontol"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.286.5446.1946","article-title":"Stimulation of bone formation in vitro and in rodents by statins","volume":"286","author":"Mundy","year":"1999","journal-title":"Science"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2165\/00003495-198836040-00003","article-title":"Lovastatin. A preliminary review of its pharmacodynamic properties and therapeutic use in hyperlipidemia","volume":"36","author":"Henwood","year":"1988","journal-title":"Drugs"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1248\/yakushi1947.111.9_469","article-title":"Research and development of pravastatin","volume":"111","author":"Kishida","year":"1991","journal-title":"Yakugaku Zasshi"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2165\/00003495-199040040-00007","article-title":"Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolemia","volume":"40","author":"Todd","year":"1990","journal-title":"Drugs"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/154405910608500608","article-title":"Simvastatin decreases IL-6 and IL-8 production in epithelial cells","volume":"85","author":"Sakoda","year":"2006","journal-title":"J Dent Res"},{"key":"R11-20250922","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1902\/jop.2009.090429","article-title":"Clinical Effect of Subgingivally Delivered Simvastatin in the Treatmen of Patients With Chronic Periodontitis: A Randomized Clinical Trial","volume":"81","author":"Pradeep","year":"2010","journal-title":"J Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01438291-201204002-00033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:21Z","timestamp":1787067981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01438291-201204002-00033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":11,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-7406.100225","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"2011-12-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}