{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:35:02Z","timestamp":1789446902239,"version":"build-2803163510"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Crohn\u2032s disease is a granulomatous inflammatory bowel disease and was described in 1932 as a chronic granulomatous disorder of the terminal ileum and is now considered a distinct member of the inflammatory bowel disease family. It may affect any part of the gastrointestinal tract. Oral Crohn\u2032s disease has been reported frequently in the last three decades with or without intestinal manifestations. In the latter case, it is considered as one of the orofacial granulomatosis. There has been much doubt whether intestinal manifestations of Crohn\u2032s disease will eventually develop in the orofacial granulomatosis. We present a female patient aged 22 years with prominent clinical findings such as persistent swelling of lower and upper lip with fissuring and angular cheilitis, granulomatous gingival enlargement, and cobblestone or corrugated appearance of labial mucosa, which are suggestive of Crohn\u2032s disease, but with no evidence of other gastrointestinal involvement. The patient underwent surgical treatment with external gingivectomy procedure. A 6-month follow-up showed minimal recurrence.<\/jats:p>","DOI":"10.4103\/0975-7406.100322","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T02:19:46Z","timestamp":1391048386000},"page":"S431-S434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Oral Crohn\u2019s disease without intestinal manifestations"],"prefix":"10.4103","volume":"4","author":[{"given":"Gingisetty","family":"Harikishan","sequence":"first","affiliation":[{"name":"Department of Periodontia, KSR Institute of Dental Science and Research, KSR Kalvi Nagar, Thokkavadi, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagate Raghavendra","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Periodontia, KSR Institute of Dental Science and Research, KSR Kalvi Nagar, Thokkavadi, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishnan","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, KSR Institute of Dental Science and Research, KSR Kalvi Nagar, Thokkavadi, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subappa","family":"Anitha","sequence":"additional","affiliation":[{"name":"Department of Periodontia, KSR Institute of Dental Science and Research, KSR Kalvi Nagar, Thokkavadi, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/0030-4220(91)90495-X","article-title":"Oral Crohn\u2032s disease with late intestinal manifestations","volume":"72","author":"Ghandour","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0757.1994.tb00030.x","article-title":"Crohn\u2032s disease: Orofacial considerations and disease pathogenesis","volume":"6","author":"Kalmar","year":"1994","journal-title":"Periodontology 2000"},{"key":"R3-20250922","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0007-117X(79)90001-5","article-title":"Oral Crohn\u2032s disease and related conditions","volume":"17","author":"Tyldesley","year":"1979","journal-title":"Br J Oral Surg"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0266-4356(89)90058-2","article-title":"Oral Crohn\u2032s disease revisited-a 10-year-review","volume":"27","author":"Field","year":"1989","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/0016-5085(82)90065-8","article-title":"Serum inhibitors of leukocyte chemotaxis in Crohn\u2032s disease and ulcerative colitis","volume":"82","author":"Rhodes","year":"1982","journal-title":"Gastroenterology"},{"key":"R8-20250922","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0016-5085(92)90098-J","article-title":"Evidence for continuous stimulation of interleukin - 6 Production in Crohn\u2032s disease","volume":"102","author":"Gross","year":"1992","journal-title":"Gastroenterology"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gut.29.9.1202","article-title":"Smoking and sugar intake are separate but interactive risk factors in Crohn\u2032s disease","volume":"29","author":"Katschinski","year":"1988","journal-title":"Gut"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.suc.2007.03.001","article-title":"Pathophysiology of inflammatory bowel disease: An overview","volume":"87","author":"Thoreson","year":"2007","journal-title":"Surg Clin North Am"},{"key":"R11-20250922","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/bmj.2.6149.1401","article-title":"Breakfast and dietary aspects of Crohn\u2032s disease","volume":"2","author":"Mayberry","year":"1978","journal-title":"Br Med J"},{"key":"R12-20250922","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1902\/jop.1978.49.9.475","article-title":"An association between Crohn\u2032s disease, periodontal disease and enhanced neutrophil function","volume":"49","author":"Lamster","year":"1978","journal-title":"J. Periodontal"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01438291-201204002-00075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:00Z","timestamp":1787068020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01438291-201204002-00075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":10,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-7406.100322","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"2011-12-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}