{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:24Z","timestamp":1787071464100,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neonatal jaundice refers to yellow coloration of the skin and the sclera (whites of the eyes) of newborn babies that result from the accumulation of bilirubin in the skin and mucous membranes. Because bilirubin is potentially toxic to the central nervous system. Genetic disorders of bilirubin conjugation, particularly the common Gilbert's syndrome, can also contribute to neonatal hyperbilirubinemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the lipid per-oxidation and antioxidant enzyme activities in patients with neonatal jaundice before and after phototherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study includes 50 neonatal jaundice patients with average age 2-15 days. All patients of neonatal jaundice receiving phototherapy except feeding, cleaning. Subjects selected were from the patients attending Pediatrics Department. Plasma malondialdehyde (MDA), erythrocyte glutathione peroxidase (GPX), superoxide dismutase and catalase (CAT) to monitor the bilirubin level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results show increased levels of bilirubin compared with controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) shows the level of plasma MDA in control, before and after phototherapy. Represents the level of GPX was significantly increased in after the phototherapy group when compared with before phototherapy and control SPSS soft ware: (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Shows the reduced glutathione (GSH) level in plasma was significantly decreased in the after phototherapy group when compared with before phototherapy and control (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). And finally with ascorbic acid and CAT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It is evident from the study that increased oxidative stress in neonatal jaundice babies leads to decrease in the levels of antioxidants like GSH and ascorbic acid and disturb their metabolism, that weaken their ability to fight the growing stress. Intense oxidative stress and decreased antioxidants may contribute to neural cell death and alter the erythrocytomembrane structure processing in neonatal jaundice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.155766","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T05:42:03Z","timestamp":1430199723000},"page":"S16-S21","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Antioxidant status in neonatal jaundice before and after phototherapy"],"prefix":"10.4103","volume":"7","author":[{"given":"S.","family":"Ayyappan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Vivekananda Dental College for Women, Trichengodu, Namakkal, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachu","family":"Philip","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Vivekananda Dental College for Women, Trichengodu, Namakkal, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bharathy","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath University, Puducherry, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath University, Puducherry, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Naveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Departments of Microbiology Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath University, Puducherry Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Swathi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Madha Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Arun","family":"Kumar","sequence":"additional","affiliation":[{"name":"Departments of Anatomy, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath University, Puducherry, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"31S","DOI":"10.1016\/0002-9343(91)90281-2","article-title":"Oxidative stress: From basic research to clinical application","volume":"91","author":"Sies","year":"1991","journal-title":"Am J Med"},{"key":"R4-20250922","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3810\/pgm.1999.11.775","article-title":"Neonatal jaundice. Strategies to reduce bilirubin-induced complications","volume":"106","author":"Melton","year":"1999","journal-title":"Postgrad Med"},{"key":"R5-20250922","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1542\/peds.94.3.291","article-title":"Early discharge of the term newborn: A continued dilemma","volume":"94","author":"Britton","year":"1994","journal-title":"Pediatrics"},{"key":"R6-20250922","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/adc.58.6.406","article-title":"Phototherapy for neonatal hyperbilirubinaemia: The importance of dose","volume":"58","author":"Modi","year":"1983","journal-title":"Arch Dis Child"},{"key":"R7-20250922","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/adc.63.7_Spec_No.748","article-title":"Serum antioxidant activity in neonates","volume":"63","author":"Sullivan","year":"1988","journal-title":"Arch Dis Child"},{"key":"R8-20250922","first-page":"286","article-title":"The neonatal erythrocyte and its oxidative susceptibility","volume":"26","author":"Jain","year":"1989","journal-title":"Semin Hematol"},{"key":"R9-20250922","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1651-2227.1985.tb10987.x","article-title":"Red cell membrane lipid peroxidation and hemolysis secondary to phototherapy","volume":"74","author":"Ostrea","year":"1985","journal-title":"Acta Paediatr Scand"},{"key":"R10-20250922","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1440-1754.2004.00489.x","article-title":"Oxidant and antioxidant levels in preterm newborns with idiopathic hyperbilirubinaemia","volume":"40","author":"Turgut","year":"2004","journal-title":"J Paediatr Child Health"},{"key":"R11-20250922","first-page":"286","article-title":"The neonatal erythrocyte and its oxidative susceptibility","volume":"26","author":"Jain","year":"1989","journal-title":"Semin Hematol"},{"key":"R12-20250922","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/S0006-291X(71)80228-0","article-title":"The role of singlet oxygen in bilirubin photo-oxidation","volume":"44","author":"McDonagh","year":"1971","journal-title":"Biochem Biophys Res Commun"},{"key":"R13-20250922","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0005-2760(96)00120-8","article-title":"Bilirubin sensitized photooxidation of human plasma low density lipoprotein","volume":"1304","author":"Hulea","year":"1996","journal-title":"Biochim Biophys Acta"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01438291-201507001-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:46:30Z","timestamp":1787067990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01438291-201507001-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":11,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-7406.155766","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"2014-10-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}