{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:14Z","timestamp":1787071574049,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Psychological conditions, particularly psychosocial stress have been implicated as risk indicators of periodontal disease. Stress increases cortisol production from the adrenal cortex by stimulating an increase in the release of ACTH from the pituitary gland. Increased cortisol production suppresses the immune response and increases the potential of periodontal tissue destruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of the present study was to estimate and compare the serum cortisol levels in periodontally diseased patients and periodontally healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Total of 45 subjects were recruited for this study and were categorized into three groups. Group I - Comprised of aggressive periodontitis patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15), Group II - Chronic periodontitis patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15), and Group III - Healthy controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15). Serum samples were collected from each of the groups and cortisol levels were determined using cortisol immunoassay kit. Clinical examination covered probing depth, gingival index (GI), gingival recession, plaque index, and clinical attachment level. The statistical analysis was done using nonparameteric\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test and Spearman's rank correlation coefficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>With respect to cortisol, the levels were higher in Group-I compared to the other groups. On comparison of mean cortisol levels among the groups, the values were statistically significant between Group-I and Group-III. Group-I showed a significant negative correlation between cortisol levels and GI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Within the limits of the study serum cortisol levels was higher in the chronic periodontitis group compared to the other groups. Positive correlation was found between the cortisol levels and other clinical parameters except for the GI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.163501","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T09:06:21Z","timestamp":1441011981000},"page":"S457-S460","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Estimation and comparison of serum cortisol levels in periodontally diseased patients and periodontally healthy individuals: A clinical-biochemical study"],"prefix":"10.4103","volume":"7","author":[{"given":"G.","family":"Rohini","sequence":"first","affiliation":[{"name":"Department of Periodontics, CSI College of Dental Sciences and Research, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kalaivani","sequence":"additional","affiliation":[{"name":"Department of Periodontics, CSI College of Dental Sciences and Research, Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Consultant Periodontist and Implantologist, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Rajasekar","sequence":"additional","affiliation":[{"name":"Consultant Oral and Maxillofacial surgeon, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaishree","family":"Tuckaram","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinisha","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Rama Dental College, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250923","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0722.1996.tb00087.x","article-title":"Emotional stress effects on immunity, gingivitis and periodontitis","volume":"104","author":"Breivik","year":"1996","journal-title":"Eur J Oral Sci"},{"key":"R2-20250923","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1600-051X.1995.tb00799.x","article-title":"Psychosocial factors in inflammatory periodontal diseases","volume":"22","author":"DaSilva","year":"1995","journal-title":"J Clin Periodontol"},{"key":"R3-20250923","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1902\/jop.1999.70.7.711","article-title":"Relationship of stress, distress and inadequate coping behaviors to periodontal disease","volume":"70","author":"Genco","year":"1999","journal-title":"J Periodontol"},{"key":"R4-20250923","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1034\/j.1600-0722.2000.00774.x","article-title":"Effects of hypothalamic-pituitary-adrenal axis reactivity on periodontal tissue destruction in rats","volume":"108","author":"Breivik","year":"2000","journal-title":"Eur J Oral Sci"},{"key":"R5-20250923","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/meta.2002.33184","article-title":"Neuroendocrine aspects of the response to stress","volume":"51","author":"Miller","year":"2002","journal-title":"Metabolism"},{"key":"R6-20250923","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1600-051X.1996.tb00611.x","article-title":"Psychosocial factors and adult onset rapidly progressive periodontitis","volume":"23","author":"Monteiro da Silva","year":"1996","journal-title":"J Clin Periodontol"},{"key":"R7-20250923","first-page":"1041","article-title":"Current view of risk factors for periodontal diseases","volume":"67","author":"Genco","year":"1996","journal-title":"J Periodontol"},{"key":"R8-20250923","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","article-title":"Periodontal disease in pregnancy. 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