{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:15Z","timestamp":1787071575076,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim and Background:<\/jats:title>\n                    <jats:p>A disintegrin and metalloproteinase 8 (ADAM8) is a marker belonging to the class of ADAM family of metalloproteinase which is found to be involved in inflammation and bone resorption in periodontal disease by acting as osteoclast stimulating factor. In several systemic inflammatory diseases, elevated levels of ADAM8 are detected in human serum and other body fluids. Recently, ADAM8 was even detected in gingival crevicular fluid (GCF) of patients with periodontal diseases. Hence, the aim of the study was to estimate the levels of ADAM8 in GCF of healthy and chronic periodontitis subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Periodontal examination and collection of GCF by the extracrevicular method was performed in 30 subjects selected randomly and categorized into two groups. Group I (healthy,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15) and Group II (chronic periodontitis,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 15). ADAM8 levels in GCF were estimated by enzyme-linked immunosorbent assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>ADAM8 was detected in both Group I and II. Highest mean ADAM8 concentration was obtained for Group II, whereas the lowest concentration was seen in Group I. This suggests that ADAM8 levels increase proportionally with the progression of periodontal disease. There was a significant correlation between ADAM8 levels and clinical parameters in the study group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results of our study indicate that the ADAM8 levels in GCF are positively associated with periodontal disease, which may provide a useful tool in monitoring its progression. Nevertheless, further longitudinal studies are required with larger sample sizes in which ADAM8 levels are progressively estimated and compared to baseline values.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.163507","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T09:06:21Z","timestamp":1441011981000},"page":"S470-S473","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study"],"prefix":"10.4103","volume":"7","author":[{"given":"Sugumari","family":"Elavarasu","sequence":"first","affiliation":[{"name":"Department of Periodontics, J. K. K. Nattraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangakumaran","family":"Suthanthiran","sequence":"additional","affiliation":[{"name":"Department of Periodontics, J. K. K. Nattraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthiie","family":"Thangavelu","sequence":"additional","affiliation":[{"name":"Department of Periodontics, J. K. K. Nattraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashakthi","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Department of Periodontics, J. K. K. Nattraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Periodontics, J. K. K. Nattraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Mohandas","sequence":"additional","affiliation":[{"name":"Department of Periodontics, J. K. K. Nattraja Dental College, Komarapalayam, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250923","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1600-051X.2004.00545.x","article-title":"Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease","volume":"31","author":"Garlet","year":"2004","journal-title":"J Clin Periodontol"},{"key":"R2-20250923","first-page":"1","article-title":"Matrix metalloproteinases \u2013 An overview","volume":"1","author":"Sekhon","year":"2010","journal-title":"Res Rep Biol"},{"key":"R3-20250923","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1006\/dbio.1995.1152","article-title":"ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain","volume":"169","author":"Wolfsberg","year":"1995","journal-title":"Dev Biol"},{"key":"R4-20250923","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.4049\/jimmunol.178.12.8053","article-title":"Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding","volume":"178","author":"G\u00f3mez-Gaviro","year":"2007","journal-title":"J Immunol"},{"key":"R5-20250923","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1359\/jbmr.2001.16.5.814","article-title":"ADAM8: A novel osteoclast stimulating factor","volume":"16","author":"Choi","year":"2001","journal-title":"J Bone Miner Res"},{"key":"R6-20250923","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1902\/jop.2012.120262","article-title":"Elevated levels of a disintegrin and metalloproteinase 8 in gingival crevicular fluid of patients with periodontal diseases","volume":"84","author":"Khongkhunthian","year":"2013","journal-title":"J Periodontol"},{"key":"R7-20250923","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/10454411930040020401","article-title":"Matrix metalloproteinases: A review","volume":"4","author":"Birkedal-Hansen","year":"1993","journal-title":"Crit Rev Oral Biol Med"},{"key":"R8-20250923","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00016350600963640","article-title":"The role of matrix metalloproteinases in the oral environment","volume":"65","author":"Hannas","year":"2007","journal-title":"Acta Odontol Scand"},{"key":"R9-20250923","doi-asserted-by":"crossref","first-page":"18209","DOI":"10.1074\/jbc.272.29.18209","article-title":"Structure of the murine CD156 gene, characterization of its promoter, and chromosomal location","volume":"272","author":"Kataoka","year":"1997","journal-title":"J Biol Chem"},{"key":"R10-20250923","doi-asserted-by":"crossref","first-page":"30469","DOI":"10.1074\/jbc.M213157200","article-title":"Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23","volume":"278","author":"Fourie","year":"2003","journal-title":"J Biol Chem"},{"key":"R11-20250923","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.atherosclerosis.2011.05.005","article-title":"Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts","volume":"218","author":"Raitoharju","year":"2011","journal-title":"Atherosclerosis"},{"key":"R12-20250923","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1165\/rcmb.2004-0026OC","article-title":"Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma","volume":"31","author":"King","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R13-20250923","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1196\/annals.1365.043","article-title":"Possible early prediction of preterm birth by determination of novel proinflammatory factors in midtrimester amniotic fluid","volume":"1092","author":"Malamitsi-Puchner","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"R14-20250923","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1158\/1078-0432.CCR-04-1436","article-title":"ADAM8 as a novel serological and histochemical marker for lung cancer","volume":"10","author":"Ishikawa","year":"2004","journal-title":"Clin Cancer Res"},{"key":"R15-20250923","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/154405910808700311","article-title":"Tumor necrosis factor-alpha-converting enzyme (TACE) levels in periodontal diseases","volume":"87","author":"Bostanci","year":"2008","journal-title":"J Dent Res"},{"key":"R16-20250923","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1523\/JNEUROSCI.20-21-07964.2000","article-title":"Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): Implications for neuron-glia interactions during neurodegeneration","volume":"20","author":"Schlomann","year":"2000","journal-title":"J Neurosci"},{"key":"R17-20250923","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/385729a0","article-title":"A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells","volume":"385","author":"Black","year":"1997","journal-title":"Nature"},{"key":"R18-20250923","first-page":"14","article-title":"The role of T cells in periodontal disease: Homeostasis and autoimmunity","volume":"2007;43","author":"Gemmell","year":"2000","journal-title":"Periodontol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01438291-201507002-00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:39Z","timestamp":1787068119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01438291-201507002-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":18,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-7406.163507","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"2015-04-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}