{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:10:41Z","timestamp":1789398641959,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives:<\/jats:title>\n                    <jats:p>Curcumin is a naturally occurring anti-inflammatory agent with various biologic and medicinal properties. Its therapeutic applications have been studied in a variety of conditions, but only few studies have evaluated the efficacy of curcumin as local drug delivery agent and in the treatment of periodontitis. The present study was to evaluate the efficacy of the adjunctive use of curcumin with scaling\/root planing as compared with scaling\/root planing alone in the treatment of the chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Thirty patients with two sites in the contralateral quadrants having probing pocket depths (PPDs) of \u22655 mm were selected. Full mouth scaling and root planing (SRP) was performed followed by application of curcumin gel on a single side. Assessment of plaque index (PI), gingival index (GI), PPD, and clinical attachment levels (CALs) were done at baseline and at 4\n                      <jats:sup>th<\/jats:sup>\n                      week. Microbiologic assessment with polymerase chain reaction was done for\n                      <jats:italic toggle=\"yes\">Porphyromonas gingivalis<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Tanerella forsythia<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Treponema denticola<\/jats:italic>\n                      by collection of plaque samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results revealed that there was a reduction in PI, GI, probing depth, CAL, and microbiologic parameters in test sites following SRP and curcumin gel application, when compared with SRP alone in control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The local application of curcumin in conjunction with scaling and root planing have showed improvement in periodontal parameters and has a beneficial effect in patients with chronic periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.163537","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T09:06:21Z","timestamp":1441011981000},"page":"S554-S558","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":51,"title":["Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: A clinical and microbiological study"],"prefix":"10.4103","volume":"7","author":[{"given":"M.","family":"Nagasri","sequence":"first","affiliation":[{"name":"Department of Periodontics, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Madhulatha","sequence":"additional","affiliation":[{"name":"Department of Periodontics, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V. V. S.","family":"Musalaiah","sequence":"additional","affiliation":[{"name":"Department of Periodontics, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Aravind","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H. Murali","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Mohan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250923","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1902\/jop.2008.070364","article-title":"Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols","volume":"79","author":"Kou","year":"2008","journal-title":"J Periodontol"},{"issue":"8 Suppl","key":"R2-20250923","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1902\/jop.2008.080213","article-title":"Mapping the pathogenesis of periodontitis: A new look","volume":"79","author":"Kornman","year":"2008","journal-title":"J Periodontol"},{"key":"R3-20250923","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1902\/jop.2006.050105","article-title":"Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid","volume":"77","author":"Mizrak","year":"2006","journal-title":"J Periodontol"},{"key":"R4-20250923","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1034\/j.1600-051x.2000.027001030.x","article-title":"The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results","volume":"27","author":"Cugini","year":"2000","journal-title":"J Clin Periodontol"},{"key":"R5-20250923","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1902\/jop.2005.76.5.778","article-title":"Effects of non-surgical mechanical therapy on the subgingival microbiota of Brazilians with untreated chronic periodontitis: 9-month results","volume":"76","author":"Colombo","year":"2005","journal-title":"J Periodontol"},{"key":"R6-20250923","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1902\/jop.2008.070308","article-title":"Clinical and microbiologic effects of subgingival controlled-release delivery of chlorhexidine chip in the treatment of periodontitis: A multicenter study","volume":"79","author":"Paolantonio","year":"2008","journal-title":"J Periodontol"},{"key":"R7-20250923","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/10454411970080020501","article-title":"Subgingival delivery of therapeutic agents in the treatment of periodontal diseases","volume":"8","author":"Soskolne","year":"1997","journal-title":"Crit Rev Oral Biol Med"},{"key":"R8-20250923","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1902\/jop.2000.71.1.125","article-title":"The role of controlled drug delivery for periodontitis. 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