{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:16Z","timestamp":1787071576855,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Matrix metalloproteinase (MMP) are involved in bone transformation at the extraction site postdental extraction. We examined the genetic association between single nucleotide polymorphisms of MMP-1 and continuous atrophy of edentulous mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Buccal cells from 33 edentulous patients were collected using sterile wooden spatula and were suspended in 15 ml falcon tubes containing 1.5 ml of cell lysis buffer, without proteinase K. The cells were transported to the laboratory on ice and were stored at \u221220\u00b0C until being processed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the samples analyzed, 26 edentulous patients (78.8%) carried 2G allele, while 7 of them (21.2%) carried 1G allele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The patients with the alveolar bone resorption exhibited more of 2G allele while only 21.2% of them showed 1G allele, associated with excessive atrophy of edentulous mandible. This study may provide genetic background to identify susceptible individuals prone to develop jawbone atrophy after dental extraction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.163591","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T09:06:21Z","timestamp":1441011981000},"page":"S652-S655","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Association of matrix metalloproteinase 1 gene promoter mutation and residual ridge resorption in edentulous patients of South Indian origin"],"prefix":"10.4103","volume":"7","author":[{"given":"S. Shyam","family":"Sundar","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ragavendar","family":"Jayesh","sequence":"additional","affiliation":[{"name":"Department of prosthodontics, Sree Balaji Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Madha Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250923","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1741-2358.2004.00007.x","article-title":"Impact of Human Genome Project on treatment of frail and edentulous patients","volume":"21","author":"Nishimura","year":"2004","journal-title":"Gerodontology"},{"key":"R2-20250923","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0022-3913(98)70116-7","article-title":"Current perspectives in residual ridge remodeling and its clinical implications: A review","volume":"80","author":"Jahangiri","year":"1998","journal-title":"J Prosthet Dent"},{"key":"R4-20250923","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1034\/j.1600-051X.2003.300202.x","article-title":"MMP-1 promoter polymorphism: Association with chronic periodontitis severity in a Brazilian population","volume":"30","author":"de Souza","year":"2003","journal-title":"J Clin Periodontol"},{"key":"R5-20250923","first-page":"233","article-title":"Genetic variations in the matrix metalloproteinase-1 promoter and risk of susceptibility and\/or severity of chronic periodontitis in the Czech population","volume":"33","author":"Holl\u00e1","year":"2007","journal-title":"J Clin Periodontol"},{"key":"R6-20250923","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12038-009-0035-1","article-title":"MMP-1 polymorphism and its relationship to pathological processes","volume":"34","author":"Arakaki","year":"2009","journal-title":"J Biosci"},{"key":"R7-20250923","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physrev.00022.2006","article-title":"Matrix metalloproteinases in lung: Multiple, multifarious, and multifaceted","volume":"87","author":"Greenlee","year":"2007","journal-title":"Physiol Rev"},{"key":"R8-20250923","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2350-9-38","article-title":"Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese","volume":"9","author":"Song","year":"2008","journal-title":"BMC Med Genet"},{"key":"R10-20250923","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1532-849X.1999.tb00005.x","article-title":"Classification system for complete edentulism. The American College of Prosthodontics","volume":"8","author":"McGarry","year":"1999","journal-title":"J Prosthodont"},{"key":"R11-20250923","first-page":"38","article-title":"Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure","volume":"19","author":"Santos","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"R12-20250923","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jcp.20948","article-title":"Regulation of matrix metalloproteinase gene expression","volume":"211","author":"Yan","year":"2007","journal-title":"J Cell Physiol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01438291-201507002-00069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:48:42Z","timestamp":1787068122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01438291-201507002-00069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":10,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-7406.163591","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"2015-04-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}