{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:47:50Z","timestamp":1787071670220,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim and Objective:<\/jats:title>\n                    <jats:p>The objective of this study is to estimate and compare the serum and salivary immunoglobulin G and A (IgG, IgA) levels in various stages of oral submucous fibrosis (OSMF) patients and relate it to total serum protein (TSP) and hemoglobin (Hb) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The sample for the present study comprised a total of 20 healthy controls, 20 OSMF patients. About 5 ml of blood and 2 ml of saliva were collected. Quantitative analysis of serum and salivary IgG, IgA was done by turbidometric immunoassay. TSP and Hb were estimated by Biuret and cyanmethemoglobin methods, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Serum and salivary IgA and IgG levels were statistically significantly increased (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) in OSMF patients when compared to controls. Also serum and salivary IgG and IgA levels showed significantly increased (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) in all the three staging of OSMF when compared to control group. Hb levels and TSP levels were significantly decreased (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) in OSMF patients when compared to controls. One-way ANOVA, Pearson's correlation, and unpaired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test were used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The elevated levels of IgG and IgA are also in favor of polygammapathy, which are nonspecific and nondiagnostic objective reflections of an underlying disease. Decreased TSP is a result of host response and Hb, acts as an indicator of nutritional status plays an important role. It is also observed from the present study that the severity of OSMF was directly proportional to the estimated elevated levels of the major IgG and IgA. A need is also felt for the knowledge of immunoprofile estimation in etiology and pathogenesis that would prove a great asset in the proper assessment of this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.191941","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T06:54:17Z","timestamp":1675839257000},"page":"S126-S132","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Comparative evaluation of serum and salivary immunoglobulin G and A levels with total serum protein in oral submucous fibrosis patients: A case control study"],"prefix":"10.4103","volume":"8","author":[{"given":"M.","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Rajas Dental College and Hospital, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Jaisanghar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Sree Anjaneya Institute of Dental Sciences, Modakkallur, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi David","family":"Austin","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar Chandan","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Oral Basic and Clinical Sciences, Division of Oral Medicine and Radiology, Qassim Private Colleges, Buraydah, Qassim Province, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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