{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:24:21Z","timestamp":1792859061317,"version":"4.5.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is believed to result from an abnormal T-cell mediated immune response. The most useful agent in the treatment is corticosteroids. The present study will be aimed at evaluation of therapeutic efficiency of two corticosteroids triamcinolone acetonate (0.1%) and clobetasol propionate with tacrolimus orabase (0.03%), an immunomodulator in the management of OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To compare the effectiveness of topical triamcinolone acetonate (0.1%), clobetasol propionate (0.05%), and tacrolimus orabase (0.03%) in the management of OLP and also to compare which has less recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>The study comprises 30 patients, all were diagnosed with OLP clinically and histopathologically. They are randomly divided into three groups: Group A - triamcinolone acetonate (0.1%), Group B - clobetasol propionate (0.05%), and Group C - tacrolimus (0.03%). A formal informed consent was obtained from all of them who participated in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion:<\/jats:title>\n                    <jats:p>Subjects in the Group A (triamcinolone 0.1%) and Group B (clobetasol 0.05%) show a significant reduction in lesion size than that of Group C (tacrolimus 0.03%). Group B (clobetasol 0.05%) shows a better significant reduction in lesion size than that of Group A (triamcinolone 0.1%). The overall treatment response was significant better in the Group B (clobetasol 0.05%). No recurrence was observed in any of the three groups at the end of 3 months. It is concluded that clobetasol propionate 0.05% ointment has higher efficacy when compared to triamcinolone acetonide 0.1% ointment and tacrolimus ointment 0.03% in the management of OLP. It was also inferred that triamcinolone 0.1% has better effects than tacrolimus 0.03%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.191976","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T06:54:17Z","timestamp":1675839257000},"page":"S86-S89","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["A randomized triple-blind clinical trial to compare the effectiveness of topical triamcinolone acetonate (0.1%), clobetasol propionate (0.05%), and tacrolimus orabase (0.03%) in the management of oral lichen planus"],"prefix":"10.4103","volume":"8","author":[{"given":"Shivakumar","family":"Sivaraman","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Vivekananda Dental College for Women, Tiruchengode, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamoorthy","family":"Santham","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, Sathyabama Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruldoss","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Rajas Dental College, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijaykumar","family":"Laliytha","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Saveetha Dental College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandian","family":"Azhalvel","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Sri Venkateshwara Dental College, Pondicherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Hearty","family":"Deepak","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Rajas Dental College, Tirunelveli, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1365-2230.2000.00607.x","article-title":"The management of oral lichen planus","volume":"25","author":"Setterfield","year":"2000","journal-title":"Clin Exp Dermatol"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1046\/j.1365-2133.1999.02672.x","article-title":"Erosive mucosal lichen planus: Response to topical treatment with tacrolimus","volume":"140","author":"Vente","year":"1999","journal-title":"Br J Dermatol"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mjd.2002.119648","article-title":"Topical tacrolimus in the treatment of symptomatic oral lichen planus: A series of 13 patients","volume":"46","author":"Rozycki","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"R4-20250925","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1067\/mjd.2002.120535","article-title":"Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus","volume":"46","author":"Kaliakatsou","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"R5-20250925","first-page":"1508","article-title":"Response of oral lichen planus to topical tacrolimus in 37 patients","volume":"140","author":"Byrd","year":"2004","journal-title":"Arch Dermatol"},{"key":"R6-20250925","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1067\/mjd.2002.126275","article-title":"An open trial of topical tacrolimus for erosive oral lichen planus","volume":"47","author":"Morrison","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"R8-20250925","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bjoms.2007.07.199","article-title":"Oral mucosal disease: Lichen planus","volume":"46","author":"Scully","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R9-20250925","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0714.2006.00441.x","article-title":"Short-term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus","volume":"35","author":"Xia","year":"2006","journal-title":"J Oral Pathol Med"},{"key":"R10-20250925","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S1079-2104(97)90244-4","article-title":"Immunologic aspects of dermal and oral lichen planus: A review","volume":"83","author":"Porter","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R11-20250925","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2340\/00015555-0070","article-title":"A comparison of treatment of oral lichen planus with topical tacrolimus and triamcinolone acetonide ointment","volume":"86","author":"Laeijendecker","year":"2006","journal-title":"Acta Derm Venereol"},{"key":"R12-20250925","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tripleo.2007.07.029","article-title":"A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus","volume":"105","author":"Radfar","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R13-20250925","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1365-2133.2004.06257.x","article-title":"Lichen planus and hepatitis C virus: A multicentre study of patients with oral lesions and a systematic review","volume":"151","author":"Lodi","year":"2004","journal-title":"Br J Dermatol"},{"key":"R14-20250925","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1365-2133.2004.05943.x","article-title":"A new delivery system of clobetasol-17-propionate (lipid-loaded microspheres 0.025%) compared with a conventional formulation (lipophilic ointment in a hydrophilic phase 0.025%) in topical treatment of atrophic\/erosive oral lichen planus A Phase IV, randomized, observer-blinded, parallel group clinical trial","volume":"150","author":"Campisi","year":"2004","journal-title":"Br J Dermatol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01438291-201608001-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:50:55Z","timestamp":1787068255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01438291-201608001-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":13,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/0975-7406.191976","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"2016-04-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}