{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:51:05Z","timestamp":1792443065101,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Peptic ulcer is a global health problem of the gastrointestinal tract characterized by mucosal damage secondary to pepsin and gastric acid secretion which occurs due to due to an imbalance between offensive and defensive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The present study was carried out with methanolic extract of the seed coat of Tamarindus indica Linn. to evaluate its antiulcer potential on ibuprofen, alcohol and pyloric ligation induced gastric lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Doses of 100 mg\/kg &amp; 200 mg\/kg of methanolic extract wre administered orally to rats of different groups. Ranitidine at a dose of 50 mg\/kg was used as a standard drug for these gastric ulcer models. The gastric content was collected and the volume was measured. The ulceration index was determined by examining the inner lining of each stomach. Furthermore, the effect was assessed by free acidity, pepsin activity, total carbohydrate (TC), protein content (PK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      The result showed that the methanolic extract of seed coats of Tamarindus indica significantly reduce the total volume of gastric juice, free and total acidity of gastric secretion (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) in pylorus ligation induced ulcer model as is comparable with the standard drug ranitidine. There was also a significant reduction in ulcer index (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) as compared to control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The methanolic extracts of seed coat of Tamarindus indica can be used as a new source of antiulcer agent in animals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0975-7406.80778","type":"journal-article","created":{"date-parts":[[2011,5,28]],"date-time":"2011-05-28T10:00:51Z","timestamp":1306576851000},"page":"236-241","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":46,"title":["Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models"],"prefix":"10.4103","volume":"3","author":[{"given":"Suresh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology Post Box: 38, Hisar, Haryana - 125001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Suman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology Post Box: 38, Hisar, Haryana - 125001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology Post Box: 38, Hisar, Haryana - 125001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kalra","sequence":"additional","affiliation":[{"name":"Rayat and Bahra Institute of Pharmacy, Mohali, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260605","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0378-8741(98)00126-3","article-title":"Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats","volume":"67","author":"Alkofahi","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"R3-20260605","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1021\/jf00048a004","article-title":"Antioxidative components isolated from the seed of Tamarind (Tamarindus indica L.)","volume":"42","author":"Tsuda","year":"1994","journal-title":"J Agri Food Chem"},{"key":"R4-20260605","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.fct.2005.05.013","article-title":"Isolation and structure elucidation of phenolic antioxidants from Tamarind (Tamarindus indica L.) seeds and pericarp","volume":"43","author":"Sudjaroen","year":"2005","journal-title":"Food Chem Toxicol"},{"key":"R5-20260605","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF02702108","article-title":"Fatty acid and sterol composition of Malagasy tamarind kernel oils","volume":"60","author":"Andriamanantena","year":"1983","journal-title":"J Am Oil Chem Soc"},{"key":"R6-20260605","first-page":"125","article-title":"Two triterpenes lupanone and lupeol isolated and identified from Tamarindus indica Linn","volume":"20","author":"Imam","year":"2007","journal-title":"Pak J Pharm Sci"},{"key":"R7-20260605","first-page":"77","article-title":"C-glycosides of Tamarind leaves","volume":"5","author":"Bhatia","year":"1996","journal-title":"Phytochemistry"},{"key":"R8-20260605","first-page":"120","article-title":"A review of current methodology for the evaluation of gastric and duodenal antiulcer agents","volume":"25","author":"Parmar","year":"1993","journal-title":"Indian J Pharmacol"},{"key":"R9-20260605","first-page":"147","article-title":"A. 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