{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:52:59Z","timestamp":1786650779768,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contemp Clin Dent"],"published-print":{"date-parts":[[2013]]},"DOI":"10.4103\/0976-237x.118342","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T05:14:21Z","timestamp":1379481261000},"page":"281","source":"Crossref","is-referenced-by-count":26,"title":["4-Hydroxy-2-nonenal, an oxidative stress marker in crevicular fluid and serum in type 2 diabetes with chronic periodontitis"],"prefix":"10.4103","volume":"4","author":[{"given":"AR","family":"Pradeep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esha","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NishanthS","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0976-237X.118342-1","first-page":"599","volume-title":"Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes","author":"Evans","year":"2002","journal-title":"Endocr Rev"},{"key":"key-10.4103\/0976-237X.118342-2","first-page":"329","volume-title":"Periodontal disease.The sixth complication of diabetes mellitus","author":"L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0976-237X.118342-3","first-page":"279","volume-title":"Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases","author":"Ding","year":"1995","journal-title":"Oral Dis"},{"key":"key-10.4103\/0976-237X.118342-4","first-page":"266","volume-title":"Cytokine networks in destructive periodontal disease","author":"Howells","year":"1995","journal-title":"Oral Dis"},{"key":"key-10.4103\/0976-237X.118342-5","first-page":"1244","volume-title":"Life below the gum line: Pathogenic mechanisms of Porphyromonas gingivalis","author":"Lamont","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"key-10.4103\/0976-237X.118342-6","first-page":"38","volume-title":"Increased release of free oxygen radicals from peripheral neutrophils in adult periodontitis after Fc delta-receptor stimulation","author":"Gustafsson","year":"1996","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.118342-7","first-page":"761","volume-title":"The neutrophil: Mechanisms of controlling periodontal bacteria","author":"Miyasaki","year":"1991","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.118342-8","first-page":"33","volume-title":"Phagocytes and oxidative stress","author":"Babior","year":"2000","journal-title":"Am J Med"},{"key":"key-10.4103\/0976-237X.118342-9","first-page":"652","volume-title":"The evolution of free radicals and oxidative stress","author":"McCord","year":"2000","journal-title":"Am J Med"},{"key":"key-10.4103\/0976-237X.118342-10","unstructured":"Sies H. Oxidative Stress: Oxidants and Antioxidants. New York: Academic Press; 1991."},{"key":"key-10.4103\/0976-237X.118342-11","first-page":"17","volume-title":"Reactive oxygen species: The unavoidable environmental insult?","author":"Gracy","year":"1999","journal-title":"Mutat Res"},{"key":"key-10.4103\/0976-237X.118342-12","first-page":"117","volume-title":"The role of lipid peroxidation in liver damage","author":"Poli","year":"1987","journal-title":"Chem Phys Lipids"},{"key":"key-10.4103\/0976-237X.118342-13","first-page":"81","volume-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","author":"Esterbauer","year":"1991","journal-title":"Free Radic Biol Med"},{"key":"key-10.4103\/0976-237X.118342-14","first-page":"2234","volume-title":"Activation of stress signaling pathways by the end product of lipid peroxidation.4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production","author":"Uchida","year":"1999","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0976-237X.118342-15","first-page":"315","volume-title":"4-Hydroxynonenal in the pathomechanisms of oxidative stress","author":"Poli","year":"2000","journal-title":"IUBMB Life"},{"key":"key-10.4103\/0976-237X.118342-16","first-page":"623","volume-title":"Lipid peroxidation and biogenic aldehydes: From the identification of 4-hydroxynonenal to further achievements in biopathology","author":"Comporti","year":"1998","journal-title":"Free Radic Res"},{"key":"key-10.4103\/0976-237X.118342-17","first-page":"277","volume-title":"Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease","author":"Onorato","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"key-10.4103\/0976-237X.118342-18","first-page":"937","volume-title":"Reactions of 4-hydroxynonenal with proteins and cellular targets","author":"Petersen","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"key-10.4103\/0976-237X.118342-19","first-page":"157","volume-title":"Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies","author":"WHO","year":"2004","journal-title":"Lancet"},{"key":"key-10.4103\/0976-237X.118342-20","doi-asserted-by":"crossref","unstructured":"Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.","DOI":"10.3109\/00016356309011240"},{"key":"key-10.4103\/0976-237X.118342-21","doi-asserted-by":"crossref","unstructured":"Executive summary: Standards of medical care in diabetes - 2010. Diabetes Care 2010;33 Suppl 1:S4-10.","DOI":"10.2337\/dc10-S004"},{"key":"key-10.4103\/0976-237X.118342-22","first-page":"171","volume-title":"Absence and presence of fluid from normal and inflamed gingivae","author":"Loe","year":"1965","journal-title":"Periodontics"},{"key":"key-10.4103\/0976-237X.118342-23","first-page":"76","volume-title":"Non-insulin dependent diabetes mellitus and alveolar bone loss progression over 2 years","author":"Taylor","year":"1998","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.118342-24","first-page":"27","volume-title":"Type 2 diabetes and oral health: A comparison between diabetic and non-diabetic subjects","author":"Sandberg","year":"2000","journal-title":"Diabetes Res Clin Pract"},{"key":"key-10.4103\/0976-237X.118342-25","first-page":"182","volume-title":"Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population","author":"Tsai","year":"2002","journal-title":"Community Dent Oral Epidemiol"},{"key":"key-10.4103\/0976-237X.118342-26","first-page":"746","volume-title":"Alveolar bone loss associated with glucose tolerance in Japanese men","author":"Marugame","year":"2003","journal-title":"Diabet Med"},{"key":"key-10.4103\/0976-237X.118342-27","first-page":"431","volume-title":"Long-term control of diabetes mellitus and periodontitis","author":"Tervonen","year":"1993","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.118342-28","first-page":"962","volume-title":"Periodontal findings in elderly patients with non-insulin dependent diabetes mellitus","author":"Collin","year":"1998","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.118342-29","first-page":"485","volume-title":"The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: The Hisayama study","author":"Saito","year":"2004","journal-title":"J Dent Res"},{"key":"key-10.4103\/0976-237X.118342-30","first-page":"615","volume-title":"Relationship between periodontal disease and diabetic retinopathy","author":"Noma","year":"2004","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0976-237X.118342-31","first-page":"537","volume-title":"Plasma lipid and blood glucose levels in patients with destructive periodontal disease","author":"L\u00f6sche","year":"2000","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.118342-32","first-page":"559","volume-title":"Periodontitis is associated with aggravation of prediabetes in Zucker fatty rats","author":"Pontes","year":"2007","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.118342-33","first-page":"306","volume-title":"Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes","author":"Shultis","year":"2007","journal-title":"Diabetes Care"},{"key":"key-10.4103\/0976-237X.118342-34","first-page":"1361","volume-title":"Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus","author":"Rodrigues","year":"2003","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.118342-35","first-page":"306","volume-title":"The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus","author":"Stewart","year":"2001","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.118342-36","first-page":"266","volume-title":"The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus","author":"Kiran","year":"2005","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.118342-37","first-page":"32","volume-title":"Formation, collection and significance of gingival crevice fluid","author":"Griffiths","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/0976-237X.118342-38","first-page":"657","volume-title":"The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations","author":"Chapple","year":"2007","journal-title":"J Nutr"},{"key":"key-10.4103\/0976-237X.118342-39","first-page":"515","volume-title":"Local and systemic total antioxidant capacity in periodontitis and health","author":"Brock","year":"2004","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.118342-40","first-page":"S110","volume-title":"Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes","author":"Green","year":"2004","journal-title":"Diabetes"},{"key":"key-10.4103\/0976-237X.118342-41","first-page":"1589","volume-title":"New insights on oxidative stress and diabetic complications may lead to a \"causal\" antioxidant therapy","author":"Ceriello","year":"2003","journal-title":"Diabetes Care"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:22:52Z","timestamp":1786648972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0976-237X.118342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013]]}},"alternative-id":["118342"],"URL":"https:\/\/doi.org\/10.4103\/0976-237x.118342","relation":{},"ISSN":["0976-237X"],"issn-type":[{"value":"0976-237X","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]}}}