{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:21Z","timestamp":1787841321342,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The lactoferrin (LF) is an iron binding protein present specifically and in abundance in the secondary granules of polymorphonuclear leukocytes (PMN's). It has been suggested that LF in crevicular fluid is a useful marker of PMN activity. Hence, this study aimed to estimate the levels of LF in gingival crevicular fluid (GCF) before and after surgical therapy in chronic periodontitis patients to assess the validity of LF in monitoring of treatment results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 30 patients with chronic periodontitis having probing depth of \u22655 mm who were scheduled for periodontal surgery were included in the study. The clinical parameters were recorded and GCF samples were obtained 2 weeks after scaling and root planing and 2 weeks after conventional flap technique. The samples collected were then assayed for LF using Enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results showed that LF levels decreased significantly from 266.53 \u00b1 75.86 to 195.47 \u00b1 74.53 after scaling and root planing. There was further significant reduction in LF levels to 90.42 \u00b1 32.89 following 2 weeks of periodontal surgery, indicating decrease in inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a significant reduction in GCF LF levels following periodontal surgery. Hence, LF levels in GCF could serve as a useful marker for monitoring of periodontal treatment results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0976-237x.128657","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T04:53:17Z","timestamp":1394599997000},"page":"25-30","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Estimation of lactoferrin levels in gingival crevicular fluid before and after periodontal therapy in patients with chronic periodontitis"],"prefix":"10.4103","volume":"5","author":[{"given":"Anasuya V.","family":"Kivadasannavar","sequence":"first","affiliation":[{"name":"Department of Dentistry, General Hospital, Bailhongal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpa S.","family":"Pudakalakatti","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Maratha Mandal's Nathajirao G. Halgekar's Institute of Dental Sciences and Research Center, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeevini A.","family":"Hattarki","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Maratha Mandal's Nathajirao G. Halgekar's Institute of Dental Sciences and Research Center, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya S.","family":"Kambali","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Maratha Mandal's Nathajirao G. Halgekar's Institute of Dental Sciences and Research Center, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1902\/jop.1992.63.4s.356","article-title":"Host response tests for diagnosing periodontal diseases","volume":"63","author":"Page","year":"1992","journal-title":"J Periodontol"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1902\/jop.1992.63.12s.1117","article-title":"The host response in gingival crevicular fluid: Potential applications in periodontitis clinical trials","volume":"63","author":"Lamster","year":"1992","journal-title":"J Periodontol"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1902\/annals.1996.1.1.37","article-title":"Periodontal diseases: Diagnosis","volume":"1","author":"Armitage","year":"1996","journal-title":"Ann Periodontol"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-051X.1993.tb01755.x","article-title":"Lactoferrin in the gingival crevice as a marker of polymorphonuclear leukocytes in periodontal disease","volume":"20","author":"Adonogianaki","year":"1993","journal-title":"J Clin Periodontol"},{"key":"R6-20250920","first-page":"31:12","article-title":"Structure and function of the tooth-interface in health and disease","volume":"2003","author":"Pollanean","year":"2000","journal-title":"Periodontol"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1600-051X.2004.00512.x","article-title":"Lactoferrin and other markers from gingival crevicular fluid and saliva before and after periodontal treatment","volume":"31","author":"Jentsch","year":"2004","journal-title":"J Clin Periodontol"},{"key":"R8-20250920","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.bdj.4809652","article-title":"Advances in periodontal diagnosis. 9. Potential markers of cell death and tissue degradation","volume":"184","author":"Eley","year":"1998","journal-title":"Br Dent J"},{"key":"R9-20250920","first-page":"326","article-title":"Contamination of gingival crevicular fluid by saliva","volume":"69","author":"Smith","year":"1990","journal-title":"J Dent Res"},{"key":"R10-20250920","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1834-7819.1998.tb00151.x","article-title":"Gingival crevicular fluid lactoferrin levels in adult periodontitis patients","volume":"43","author":"Tsai","year":"1998","journal-title":"Aust Dent J"},{"key":"R11-20250920","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0765.2004.00744.x","article-title":"The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1\u03b2 in gingival crevicular fluid: Implications for oxidative stress in human periodontal diseases","volume":"39","author":"Wei","year":"2004","journal-title":"J Periodontal Res"},{"key":"R12-20250920","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1034\/j.1600-051X.2002.290613.x","article-title":"PMN responses in chronic periodontal disease: Evaluation by gingival crevicular fluid enzymes and elastase-alpha-1-proteinase inhibitor complex","volume":"29","author":"Buchmann","year":"2002","journal-title":"J Clin Periodontol"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01535384-201405010-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:37Z","timestamp":1787838517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01535384-201405010-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/0976-237x.128657","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}