{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:09:34Z","timestamp":1789639774804,"version":"4.0.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contemp Clin Dent"],"published-print":{"date-parts":[[2015]]},"DOI":"10.4103\/0976-237x.166816","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T08:59:55Z","timestamp":1444208395000},"page":"152","source":"Crossref","is-referenced-by-count":81,"title":["Estimation of salivary tumor necrosis factor-alpha in chronic and aggressive periodontitis patients"],"prefix":"10.4103","volume":"6","author":[{"given":"SheejaS","family":"Varghese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ND","family":"Jayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sankari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema","family":"Lakshmanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/0976-237X.166816-1","first-page":"322","volume-title":"Salivary biomarkers of existing periodontal disease: A cross-sectional study","author":"Miller","year":"2006","journal-title":"J Am Dent Assoc"},{"key":"key-10.4103\/0976-237X.166816-2","first-page":"668","volume-title":"Immunogenetics.Defence by diversity","author":"Hill","year":"1999","journal-title":"Nature"},{"key":"key-10.4103\/0976-237X.166816-3","first-page":"482","volume-title":"The potential role of chemokines and inflammatory cytokines in periodontal disease progression","author":"Graves","year":"1999","journal-title":"Clin Infect Dis"},{"key":"key-10.4103\/0976-237X.166816-4","first-page":"230","volume-title":"The role of inflammatory mediators in the pathogenesis of periodontal disease","author":"Page","year":"1991","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0976-237X.166816-5","unstructured":"Newman MG, Takei HH, Klokkevold PR, Carranza FA. Microbial interactions with the host in periodontal disease. Clinical Periodontology. 10th ed. Saunders Elsevier; Northwestern University, United States: 2006. p. 239."},{"key":"key-10.4103\/0976-237X.166816-6","first-page":"813","volume-title":"Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1(LFA-1)","author":"Marlin","year":"1987","journal-title":"Cell"},{"key":"key-10.4103\/0976-237X.166816-7","first-page":"630","volume-title":"Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha","author":"Leibovich","year":"1987","journal-title":"Nature"},{"key":"key-10.4103\/0976-237X.166816-8","first-page":"984","volume-title":"Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells","author":"Beutler","year":"1985","journal-title":"J Exp Med"},{"key":"key-10.4103\/0976-237X.166816-9","first-page":"507","volume-title":"Local factors in bone remodeling","author":"Mundy","year":"1989","journal-title":"Recent Prog Horm Res"},{"key":"key-10.4103\/0976-237X.166816-10","first-page":"453","volume-title":"Analysis of saliva for periodontal diagnosis \u2013 A review","author":"Kaufman","year":"2000","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.166816-11","first-page":"52","volume-title":"Saliva as a diagnostic tool for periodontal disease: Current state and future directions","author":"Giannobile","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/0976-237X.166816-12","first-page":"1913","volume-title":"Bone remodeling biomarkers of periodontal disease in saliva","author":"Frodge","year":"2008","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.166816-13","first-page":"252","volume-title":"Candidate salivary biomarkers associated with alveolar bone loss: Cross-sectional and in vitro studies","author":"Ng","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key-10.4103\/0976-237X.166816-14","first-page":"411","volume-title":"Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: A cross-sectional study","author":"Teles","year":"2009","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/0976-237X.166816-15","first-page":"737","volume-title":"Evaluation of salivary tumor necrosis factor-alpha in patients with the chronic periodontitis: A case-control study","author":"Yousefimanesh","year":"2013","journal-title":"J Indian Soc Periodontol","ISSN":"https:\/\/id.crossref.org\/issn\/0972-124X","issn-type":"print"},{"key":"key-10.4103\/0976-237X.166816-16","first-page":"24","volume-title":"Levels of interleukin-1beta and tumor necrosis factor-alpha in patients with aggressive periodontitis","author":"Sun","year":"2008","journal-title":"Beijing Da Xue Xue Bao"},{"key":"key-10.4103\/0976-237X.166816-17","first-page":"435","volume-title":"Proinflammatory factors in saliva as possible markers for periodontal disease","author":"Aurer","year":"2005","journal-title":"Coll Antropol"},{"key":"key-10.4103\/0976-237X.166816-18","first-page":"270","volume-title":"Saliva and serum levels of B-cell activating factors and tumor necrosis factor \u2013 A in patients with periodontitis","author":"G\u00fcm\u00fcs","year":"2014","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.166816-19","first-page":"1849","volume-title":"Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumour necrosis factor alpha in patients with chronic and aggressive periodontitis","author":"Kurtis","year":"2005","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.166816-20","first-page":"82","volume-title":"TNF-alpha and IL-4 levels in generalized aggressive periodontitis subjects","author":"Bastos","year":"2009","journal-title":"Oral Dis"},{"key":"key-10.4103\/0976-237X.166816-21","first-page":"1046","volume-title":"Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis","author":"G\u00f3rska","year":"2003","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.166816-22","first-page":"2276","volume-title":"Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis","author":"Havemose-Poulsen","year":"2005","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.166816-23","first-page":"1047","volume-title":"Imbalance between soluble tumour necrosis factor receptors type 1 and 2 in chronic periodontitis","author":"Ikezawa","year":"2005","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/0976-237X.166816-24","unstructured":"Teresa K, Jan V, Joost JO. Proinflammatory cytokines TNF and IL-1 families. Fundamental Immunology. 4th ed. Lippincott Raven: Philadelphia; 1999. p. 775-83."},{"key":"key-10.4103\/0976-237X.166816-25","first-page":"1","volume-title":"Structure of the microbial flora associated with periodontal health and disease in man.A light and electron microscopic study","author":"Listgarten","year":"1976","journal-title":"J Periodontol"},{"key":"key-10.4103\/0976-237X.166816-26","first-page":"861","volume-title":"Salivary flow rate and pH during prolonged gum chewing in humans","author":"Polland","year":"2003","journal-title":"J Oral Rehabil"},{"key":"key-10.4103\/0976-237X.166816-27","first-page":"507","volume-title":"Effects of furosemide and bendroflumethiazide on saliva flow rate and composition","author":"Nederfors","year":"2004","journal-title":"Arch Oral Biol"},{"key":"key-10.4103\/0976-237X.166816-28","first-page":"1123","volume-title":"Periodontal disease and cardiovascular disease","author":"Beck","year":"1996","journal-title":"J Periodontol"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:29:16Z","timestamp":1786649356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0976-237X.166816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015]]}},"alternative-id":["166816"],"URL":"https:\/\/doi.org\/10.4103\/0976-237x.166816","relation":{},"ISSN":["0976-237X"],"issn-type":[{"value":"0976-237X","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}