{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:38:44Z","timestamp":1787071124211,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Anaplastic large cell lymphoma (ALCL) is an uncommon disease, accounting for &lt;5% of all cases of non-Hodgkin's lymphoma. We report a case of 48-year-old male who presented a clinically benign swelling in the right anterior palatal region since last 2 months. Radiographic evaluation showed no bone loss in palatal area. Histological and radiological examination was in favor of a peripheral reactive lesion like pyogenic granuloma or a benign salivary gland tumor. Immunohistochemistry confirmed the diagnosis of anaplastic lymphoma kinase-negative (ALK(\u2212)) ALCL. Further laboratory tests ELISA for human immunodeficiency virus (HIV) and CD4 cell count was done which showed positivity for HIV. To the best of our knowledge, it is the first case of ALK(\u2212) ALCL in the hard palate presenting as the first clinical manifestation of acquired immune deficiency syndrome.<\/jats:p>","DOI":"10.4103\/0976-237x.177115","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T04:11:54Z","timestamp":1456114314000},"page":"114-117","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Anaplastic lymphoma kinase negative anaplastic large cell lymphoma of hard palate as first clinical manifestation of acquired immune deficiency syndrome"],"prefix":"10.4103","volume":"7","author":[{"given":"Anjali","family":"Narwal","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achla Bharti","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sant","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shally","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Chandigarh, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250921","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0889-8588(05)70387-7","article-title":"Diagnosis and management of systemic non-Hodgkin's lymphoma in HIV disease","volume":"10","author":"Sandler","year":"1996","journal-title":"Hematol Oncol Clin North Am"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0140-6736(91)92513-2","article-title":"AIDS-associated non-Hodgkin lymphoma","volume":"337","author":"Beral","year":"1991","journal-title":"Lancet"},{"key":"R3-20250921","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"R4-20250921","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/MOH.0b013e32832b89a9","article-title":"The spectrum of peripheral T-cell lymphomas","volume":"16","author":"O'leary","year":"2009","journal-title":"Curr Opin Hematol"},{"key":"R6-20250921","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1182\/blood.V66.4.848.848","article-title":"The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells","volume":"66","author":"Stein","year":"1985","journal-title":"Blood"},{"issue":"Suppl 3","key":"R7-20250921","first-page":"538","article-title":"Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM\/ALK: A distinct clinicopathologic entity","volume":"11","author":"Shiota","year":"1997","journal-title":"Leukemia"},{"key":"R8-20250921","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/path.1331","article-title":"ALK-negative systemic anaplastic large cell lymphoma: Differential diagnostic and prognostic aspects \u2013 A review","volume":"200","author":"Ten Berge","year":"2003","journal-title":"J Pathol"},{"key":"R9-20250921","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2559.2006.02369.x","article-title":"Update on extranodal lymphomas. Conclusions of the Workshop held by the EAHP and the SH in Thessaloniki, Greece","volume":"48","author":"Campo","year":"2006","journal-title":"Histopathology"},{"key":"R10-20250921","first-page":"852932","article-title":"Gingival anaplastic large-cell lymphoma mimicking hyperplastic benignancy as the first clinical manifestation of AIDS: A case report and review of the literature","author":"Rozza-de-Menezes","year":"2013","journal-title":"Case Rep Dent 2013"},{"key":"R11-20250921","first-page":"79","article-title":"Anaplastic large cell lymphoma (ALCL) in the oral mucosa with repeating recurrence and spontaneous regression of ulceration: Report of a case","volume":"7","author":"Notani","year":"2002","journal-title":"Oral Med Radiol"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01535384-201607010-00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:50Z","timestamp":1787067710000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01535384-201607010-00026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/0976-237x.177115","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}