{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T21:53:40Z","timestamp":1725314020769},"reference-count":0,"publisher":"Scientific Scholar","issue":"S 01","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":2125,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Aims: We present retrospective analysis of patients of glioblastoma multiforme (GBM) and discuss clinical characteristics, various treatment protocols, survival outcomes, and prognostic factors influencing survival. Materials and Methods: From January 2002 to June 2009, 439 patients of GBM were registered in our department. The median age of patients was 50 years, 66.1% were males, and 75% underwent complete or near-total excision. We evaluated those 360 patients who received radiotherapy (RT). Radiotherapy schedule was selected depending upon pre-RT Karnofsky Performance Status (KPS). Patients with KPS &lt; 70 (Group I, n = 48) were planned for RT dose of 30-35 Gy in 10-15 fractions, and patients with KPS \u2265 70 (Group II, n = 312) were planned for 60 Gy in 30 fractions. In group I, six patients and in group II, 89 patients received some form of chemotherapy (lomustine or temozolomide). Statistical Analysis Used: Statistical analysis was done using Statistical Package for Social Sciences, version 12.0. Overall survival (OS) was calculated using Kaplan-Meier method, and prognostic factors were determined by log rank test. The Cox proportional hazards model was used for multivariate analysis. Results: The median follow-up was 7.53 months. The median and 2-year survival rates were 6.33 months and 2.24% for group I and 7.97 months and 8.21% for group II patients, respectively ( P = 0.001). In multivariate analysis, site of tumor (central vs. others; P = 0.006), location of tumor (parietal lobe vs. others; P = 0.003), RT dose (&lt;60 Gy vs. 60 Gy; P = 0.0001), and use of some form of chemotherapy ( P = 0.0001) were independent prognostic factors for survival. Conclusions: In patients with GBM, OS and prognosis remains dismal. Whenever possible, we should use concurrent and\/or adjuvant chemotherapy to maximize the benefits of post-operative radiotherapy. Patients with poor performance status may be considered for hypofractionated RT schedules, which have similar median survival rates as conventional RT.<\/jats:p>","DOI":"10.4103\/0976-3147.116455","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T10:23:01Z","timestamp":1376389381000},"page":"S46-S55","source":"Crossref","is-referenced-by-count":15,"special_numbering":"S","title":["Evaluation of outcome and prognostic factors in patients of glioblastoma multiforme: A single institution experience"],"prefix":"10.25259","volume":"04","author":[{"given":"Narendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabab Lalit","family":"Angurana","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Khosla","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan Kumar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Sector - 12, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupali","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan","family":"Bera","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh Chander","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology,India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,26]]},"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0976-3147.116455.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:32:51Z","timestamp":1691209971000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/evaluation-of-outcome-and-prognostic-factors-in-patients-of-glioblastoma-multiforme-a-single-institution-experience\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":0,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2019,9,26]]},"published-print":{"date-parts":[[2013,12]]}},"URL":"https:\/\/doi.org\/10.4103\/0976-3147.116455","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}