{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:40:12Z","timestamp":1691210412790},"reference-count":29,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":1820,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Craniosynostosis (CS) is premature fusion of skull. It is divided into two groups: Syndromic craniosynostosis (SCS) and non-syndromic craniosynostosis (NSC). Its incidence in Indian population is 1:1000 live births where as in the USA it is 1:2500 live births. Its incidence varies from country to country. Molecular genetics having great interest and relevance in medical students, faculty, scientist, pediatric neurosurgeon and staff nurses, our objective was to educate the medical students, residents, researchers, clinicians, pediatric neurosurgeon, anesthetists, pediatricians, staff nurses and paramedics. We summarized here including with diagnosis, investigations, surgical therapy, induction therapy, and molecular therapy. Molecular genetics training is needed to know the information regarding development of skull, cranial connective tissue, craniofacial dysplasia, frame work, network of receptors and its etiopathogenesis. The important part is clinically with molecular therapy (MT) how to manage CS in rural sector and metropolitan cities need a special attention.<\/jats:p>","DOI":"10.4103\/0976-3147.140014","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T05:36:29Z","timestamp":1409722589000},"page":"428-432","source":"Crossref","is-referenced-by-count":0,"title":["Strengthening molecular genetics and training in craniosynostosis: The need of the hour"],"prefix":"10.25259","volume":"05","author":[{"given":"Mayadhar","family":"Barik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minu","family":"Bajpai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shasanka Shekhar","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotish Chandra","family":"Samantaray","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sada Nanda","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"key-10.4103\/0976-3147.140014-1","first-page":"2032","volume-title":"Management of craniosynostosis","author":"Panchal","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"key-10.4103\/0976-3147.140014-2","first-page":"198","volume-title":"Combined report of problems and complications in 793 craniofacial operations","author":"Whitakar","year":"1979","journal-title":"Plast Reconstr Surg"},{"key":"key-10.4103\/0976-3147.140014-3","unstructured":"Grabb WC, Smith JW, Aston SJ. Plastic Surgery. 4 th ed. Boston: Little, Brown; 1991."},{"key":"key-10.4103\/0976-3147.140014-4","first-page":"22","volume-title":"Anesthesia for surgery related to craniosynostosis: A review.Part 2","author":"Hughes","year":"2013","journal-title":"Pediatr Anaesth"},{"key":"key-10.4103\/0976-3147.140014-5","first-page":"107","volume-title":"Blood loss and replacement for paediatric cranioplasty in Australlia-a prospective national audit","author":"Howe","year":"2012","journal-title":"Anesth Intensive Care"},{"key":"key-10.4103\/0976-3147.140014-6","first-page":"525","volume-title":"Blood-conservation techniques in craniofacial surgery","author":"Meara","year":"2005","journal-title":"Ann Plast Surg"},{"key":"key-10.4103\/0976-3147.140014-7","unstructured":"Townsend M Jr, Beauchamp RD, Evers BM, Mattox KL. Craniofacial surgery. In: Evers BM, Townsend CM, Mattox KL, Beauchamp RD, editors. Pediatric Plastic Surgery. 19 th ed. 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