{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T16:26:38Z","timestamp":1720715198814},"reference-count":24,"publisher":"Scientific Scholar","issue":"S 01","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":1760,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Background: Dexmedetomidine, a predominant alpha-2-adrenergic agonist has been used in anesthetic practice to provide good sedation. The drug is being recently used in neuroanesthesia during awake surgery for brain tumors and in functional neurosurgery. Materials and Methods: This prospective study analyzed the hemodynamic effects of dexmedetomidine infusion during electrocorticography in patients undergoing surgery for mesial temporal sclerosis. Dexmedetomidine infusion was administered during intra-operative electrocorticography recording, 15 minutes after the end tidal MAC of N 2 O and isoflurane were decreased to zero. Anesthesia was maintained with O 2 :air mixture = 50:50, vecuronium and fentanyl. Heart rate (HR), mean arterial pressure (MAP) and end tidal carbon dioxide (ETCO 2) were recorded across at induction, 2 min prior to dexmedetomidine (PreDEX), 5 min during dexmedetomidine infusion (DEX; 1 \u03bcg\/kg), 5 min after stopping dexmedetomidine and 10 minutes after stopping dexmedetomidine. Results: Forty patients with mesial temporal sclerosis (M: F = 27:13, mean age = 28.15 \u00b1 10.9 years; duration of epilepsy = 12.0 \u00b1 7.9 years) underwent anterior temporal lobe resection with amygdalohippocampectomy for drug-resistant epilepsy. Infusion of dexmedetomidine caused a transient fall in HR in 87.5% of patients and an increase in MAP in 62.5% of patients, which showed a tendency to revert back towards PreDEX values within 10 min after stopping the infusion. Sixty-five percent of the patients showed \u226425% reduction and 10% of them showed &gt;25% reduction in HR. 47.5% of the patients showed \u226425% increase and 15% of them showed &gt;25% increase in MAP. These changes were over a narrow range and within physiological limits. Conclusion: The infusion of dexmedetomidine for a short period causes reduction of HR and increase in MAP in patients, however the variations are within acceptable range.<\/jats:p>","DOI":"10.4103\/0976-3147.145195","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T11:04:26Z","timestamp":1416567866000},"page":"S017-S021","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Hemodynamic effects of dexmedetomidine during intra-operative electrocorticography for epilepsy surgery"],"prefix":"10.25259","volume":"05","author":[{"given":"G.","family":"Chaitanya","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Arivazhagan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjib","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. R. Madhusudan","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Neuro Anesthesiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Thennarasu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Bharath","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Bhaskara","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Chandramouli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Satishchandra","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"key-10.4103\/0976-3147.145195-1","first-page":"1340","volume-title":"The effect of dexmedetomidine on perioperative hemodynamics in patients undergoing craniotomy","author":"Bekker","year":"2008","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0976-3147.145195-2","first-page":"1163","volume-title":"The effects of dexmedetomidine\/remifentanil and midazolam\/remifentanil on auditory-evoked potentials and electroencephalogram at light-to-moderate sedation levels in healthy subjects","author":"Haenggi","year":"2006","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0976-3147.145195-3","first-page":"89","volume-title":"Use of dexmedetomidine and ketamine infusions during scoliosis repair surgery with somatosensory and motor-evoked potential monitoring: A case report","author":"Brennen","year":"2011","journal-title":"AANA J"},{"key":"key-10.4103\/0976-3147.145195-4","first-page":"1317","volume-title":"Dexmedetomidine and arousal affect subthalamic neurons","author":"Elias","year":"2008","journal-title":"Mov Disord"},{"key":"key-10.4103\/0976-3147.145195-5","first-page":"537","volume-title":"Anesthesia for functional neurosurgery: The role of dexmedetomidine","author":"Rozet","year":"2008","journal-title":"Curr Opin Anaesthesiol"},{"key":"key-10.4103\/0976-3147.145195-6","first-page":"417","volume-title":"Motor and somatosensory evoked potentials are well maintained in patients given dexmedetomidine during spine surgery","author":"Bala","year":"2008","journal-title":"Anesthesiology"},{"key":"key-10.4103\/0976-3147.145195-7","first-page":"393","volume-title":"Management of anesthesia in awake craniotomy","author":"Piccioni","year":"2008","journal-title":"Minerva Anestesiol"},{"key":"key-10.4103\/0976-3147.145195-8","first-page":"49","volume-title":"A neuronal mechanism of propofol-induced central respiratory depression in newborn rats","author":"Kashiwagi","year":"2004","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0976-3147.145195-9","first-page":"122","volume-title":"The effect-site concentration of propofol producing respiratory depression during spinal anesthesia","author":"Lee","year":"2011","journal-title":"Korean J Anesthesiol"},{"key":"key-10.4103\/0976-3147.145195-10","first-page":"503","volume-title":"The mechanism of alpha2-adrenergic inhibition of sympathetic ganglionic transmission","author":"McCallum","year":"1998","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0976-3147.145195-11","first-page":"271","volume-title":"Pharmacodynamics of alpha2-adrenoceptor agonists","author":"Talke","year":"2000","journal-title":"Best Practice and Research: Clinical Anaesthesiology"},{"key":"key-10.4103\/0976-3147.145195-12","first-page":"834","volume-title":"The hemodynamic and adrenergic effects of perioperative dexmedetomidine infusion after vascular surgery","author":"Talke","year":"2000","journal-title":"Anesth Analg"},{"key":"key-10.4103\/0976-3147.145195-13","doi-asserted-by":"crossref","unstructured":"Bloor BC, Ward DS, Belleville JP, Maze M. 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