{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:37:04Z","timestamp":1777347424981,"version":"3.51.4"},"reference-count":0,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":1456,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Central nervous system (CNS) involvement is a known complication of scrub typhus which range from mild meningitis to frank meninigoencephalitis. Aims and objectives: To study the clinical feature, laboratory parameters and response to treatment of scrub typhus meningitis\/meningoencephalitis. Methods and Materials: This is a hospital based prospective observational study from North Eastern India. Diagnosis was based on clinical features and positive serological test (Weil's Felix test and IgM antibody card test). Results: 13 patients of scrub typhus with features of meningitis\/meningoencephalitis were included. The mean duration of fever before presentation was 5.61\u00b13.08 days and 4 (30.76 %) patients had eschar. Altered sensorium, headache, seizure and meningeal sign were present in 13 (100%), 13 (100%), 6 (46.15%) and 10 (76.92%) patients respectively. Mean CSF protein, glucose and Adenosine deaminase was 152.16\u00b116.88mg\/dl, 55.23\u00b121.7mg\/dl, and 16.98\u00b17.37U\/L respectively. Mean total count of CSF leukocyte and lymphocyte percentage was 46.07\u00b1131 cell\/cumm and 98.66\u00b13.09% respectively. Tablet doxycycline with or without injection azithromycin was used and that shows good response 15.38% of patients died and all of them had multi organ dysfunction. Conclusion: Meningoencephalitis is a common manifestation of scrub typhus and diagnosis requires high degree of clinical suspicion which if diagnosed early and specific treatment started, patients usually recover completely with few complications.<\/jats:p>","DOI":"10.4103\/0976-3147.169769","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T07:13:33Z","timestamp":1447917213000},"page":"488-493","source":"Crossref","is-referenced-by-count":33,"title":["Scrub typhus meningoencephalitis, a diagnostic challenge for clinicians: A hospital based study from North-East India"],"prefix":"10.25259","volume":"06","author":[{"given":"M. D.","family":"Jamil","sequence":"additional","affiliation":[{"name":"Departments of Medicine, NEIGRIHMS, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaraf","family":"Hussain","sequence":"additional","affiliation":[{"name":"Departments of Neurology, NEIGRIHMS, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monaliza","family":"Lyngdoh","sequence":"additional","affiliation":[{"name":"Departments of Medicine, NEIGRIHMS, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shriram","family":"Sharma","sequence":"additional","affiliation":[{"name":"Departments of Neurology, NEIGRIHMS, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhupen","family":"Barman","sequence":"additional","affiliation":[{"name":"Departments of Medicine, NEIGRIHMS, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P K.","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Departments of Medicine, NEIGRIHMS, Shillong, Meghalaya, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,26]]},"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0976-3147.169769.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:20:46Z","timestamp":1691209246000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/scrub-typhus-meningoencephalitis-a-diagnostic-challenge-for-clinicians-a-hospital-based-study-from-north-east-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,9,26]]},"published-print":{"date-parts":[[2015,10]]}},"URL":"https:\/\/doi.org\/10.4103\/0976-3147.169769","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}