{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:19:08Z","timestamp":1789096748365,"version":"build-2803163510"},"reference-count":9,"publisher":"Scientific Scholar","issue":"03","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":1181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Wilson's disease is a metabolic disorder which presents with hepatitis or hepatic decompensation commonly. Neurologic manifestations are late and include movement disorders, personality changes, and seizures. Magnetic resonance imaging (MRI) brain shows high signal changes in putamen, lentiform nucleus, thalamus, and brainstem. White matter lesions are rare. We report a child of Wilson's disease who presented to us with dystonia, rigidity, myoclonus and had symmetrical white matter changes in the fronto-parietooccipital region. Diffusion restriction in bilateral frontoparietal areas was also seen which is rare in chronic cases like ours. Atypical MRI characteristics should be considered in patients with clinical signs of neurological involvement in Wilson's disease as it is a devastating but treatable disease.<\/jats:p>","DOI":"10.4103\/0976-3147.176195","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T00:01:29Z","timestamp":1455235289000},"page":"447-449","source":"Crossref","is-referenced-by-count":4,"title":["White matter changes in Wilson\u2019s disease: A radiological enigma"],"prefix":"10.25259","volume":"07","author":[{"given":"Soumava","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavesh","family":"Solanki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goutam","family":"Guha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar Prasad","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"key-10.4103\/0976-3147.176195-1","unstructured":"Brewer GJ. Wilsons disease. In: Harrisons Principles of Internal Medicine. 18th ed. New york: McGraw-Hill; 2012. p. 3188-90."},{"key":"key-10.4103\/0976-3147.176195-2","first-page":"27","volume-title":"Wilson's disease: MRI features","author":"Singh","year":"2011","journal-title":"J Pediatr Neurosci","ISSN":"https:\/\/id.crossref.org\/issn\/1817-1745","issn-type":"print"},{"key":"key-10.4103\/0976-3147.176195-3","first-page":"531","volume-title":"Wilson disease: Findings at MR imaging and CT of the brain with clinical correlation","author":"van","year":"1996","journal-title":"Radiology"},{"key":"key-10.4103\/0976-3147.176195-4","first-page":"157","volume-title":"Wilson's disease: MRI demonstration of cavitations in basal ganglia and thalami","author":"Sener","year":"1993","journal-title":"Pediatr Radiol"},{"key":"key-10.4103\/0976-3147.176195-5","first-page":"312","volume-title":"Atypical MRI features involving the brain in Wilson's disease","author":"Yousaf","year":"2009","journal-title":"Radiol Case Rep"},{"key":"key-10.4103\/0976-3147.176195-6","first-page":"130","volume-title":"Magnetic resonance imaging of the brain in Wilson's disease","author":"Nazer","year":"1993","journal-title":"Neuroradiology"},{"key":"key-10.4103\/0976-3147.176195-7","first-page":"602","volume-title":"Wilson's disease: Clinical and radiological features","author":"Jha","year":"1998","journal-title":"J Assoc Physicians India"},{"key":"key-10.4103\/0976-3147.176195-8","first-page":"2021","volume-title":"Cranial MR in Wilson disease: Abnormal white matter in extrapyramidal and pyramidal tracts","author":"van","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"key-10.4103\/0976-3147.176195-9","doi-asserted-by":"crossref","unstructured":"Patell R, Dosi R, Joshi HK, Storz D. Atypical neuroimaging in Wilson's disease. BMJ Case Rep 2014;2014. pii: Bcr2013200100.","DOI":"10.1136\/bcr-2013-200100"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0976-3147.176195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:19:30Z","timestamp":1691209170000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/white-matter-changes-in-wilsons-disease-a-radiological-enigma\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":9,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,9,25]]},"published-print":{"date-parts":[[2016,7]]}},"URL":"https:\/\/doi.org\/10.4103\/0976-3147.176195","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]}}}