{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:29:05Z","timestamp":1787030945443,"version":"build-2736575974"},"reference-count":7,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:00:00Z","timestamp":1569456000000},"content-version":"vor","delay-in-days":1273,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurosciences in Rural Practice"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Wilson\u2019s disease is a multisystem disorder which manifests with hepatic, neurological, musculoskeletal, hematological, renal, and cardiac symptoms. The hepatic and neurological manifestations often overshadow the other system involvement including cardiac symptoms and signs, which may prove fatal. We report a case of a young female who presented with progressive parkinsonian features and dystonia for around 4 months followed 2 months later by the complaint of episodes of light-headedness. She was diagnosed to have Wilson\u2019s disease based on the presence of Kayser\u2013Fleischer ring and laboratory parameters of copper metabolism. Electrocardiography of the patient incidentally revealed 2nd degree Mobitz type-1 atrioventricular block explaining her episodes of light-headedness. She was started on penicillamine and trihexyphenidyl. The heart block improved spontaneously. Cardiac autonomic function tests including blood pressure response to standing and heart rate response to standing were observed to be normal. We review the literature on cardiac manifestations of Wilson\u2019s disease and emphasize that patients with Wilson\u2019s disease should be assessed for cardiac arrhythmia and cardiac dysfunction as these may have therapeutic and prognostic implications.<\/jats:p>","DOI":"10.4103\/0976-3147.186982","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:09:05Z","timestamp":1469509745000},"page":"587-589","source":"Crossref","is-referenced-by-count":10,"title":["Cardiac arrhythmia in Wilson\u2019s disease: An oversighted and overlooked entity!"],"prefix":"10.25259","volume":"7","author":[{"given":"Bhupender Kumar","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Neurology, PGIMER and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Department of Neurology, PGIMER and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, PGIMER and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neurology, PGIMER and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2019,9,26]]},"reference":[{"key":"key-10.4103\/0976-3147.186982-1","first-page":"579","volume-title":"Cardiac Wilson's disease","author":"Kuan","year":"1987","journal-title":"Chest"},{"key":"key-10.4103\/0976-3147.186982-2","first-page":"269","volume-title":"Cardiac involvement in Wilson disease","author":"Hlubock\u00e1","year":"2002","journal-title":"J Inherit Metab Dis"},{"key":"key-10.4103\/0976-3147.186982-3","unstructured":"Walshe JM. Wilson's disease. In: Vinken PJ, Bruyn GW, Klawans HL, editors. Handbook of Clinical Neurology. Vol. 49. Amsterdam: Elsevier; 1986. p. 223-38."},{"key":"key-10.4103\/0976-3147.186982-4","first-page":"112","volume-title":"Wilson disease: Description of 282 patients evaluated over 3 decades","author":"Taly","year":"2007","journal-title":"Medicine (Baltimore)"},{"key":"key-10.4103\/0976-3147.186982-5","first-page":"294","volume-title":"Cardiac involvement in Wilson's disease \u2013 An electrocardiographic observation","author":"Meenakshi-Sundaram","year":"2004","journal-title":"J Assoc Physicians India"},{"key":"key-10.4103\/0976-3147.186982-6","first-page":"531","volume-title":"Hepatolenticular degeneration \u2013 Is the term too narrow to explain Wilson's disease?","author":"Fatima","year":"2014","journal-title":"J Assoc Physicians India"},{"key":"key-10.4103\/0976-3147.186982-7","first-page":"678","volume-title":"Myocardial integrated ultrasonic backscatter for early detection of cardiac involvement in patients with Wilson disease","author":"Arat","year":"2014","journal-title":"Turk J Gastroenterol"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/0976-3147.186982.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T11:17:42Z","timestamp":1664795862000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/0976-3147.186982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":7,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,9,26]]},"published-print":{"date-parts":[[2016,4]]}},"URL":"https:\/\/doi.org\/10.4103\/0976-3147.186982","relation":{},"ISSN":["0976-3147","0976-3155"],"issn-type":[{"value":"0976-3147","type":"print"},{"value":"0976-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}