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Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. Am J Med 1991;91:14S-22S.\nArnhold J. Free radicals \u2013 Friends or foes? Properties, functions, and secretion of human myeloperoxidase. Biochemistry (Mosc) 2004;69:4-9.\nDhalla NS, Temsah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J Hypertens 2000;18:655-73.\nHitchon CA, El-Gabalawy HS. Oxidation in rheumatoid arthritis. Arthritis Res Ther 2004;6:265-78.\nCeriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004;24:816-23.\nChapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontol 2000 2007;43:160-232.\nLiu Z, Liu Y, Song Y, Zhang X, Wang S, Wang Z. Systemic oxidative stress biomarkers in chronic periodontitis: A meta-analysis. 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J Periodontol 2009;80:364-71.\nLobene RR, Weatherford T, Ross NM, Lamm RA, Menaker L. A modified gingival index for use in clinical trials. Clin Prev Dent 1986;8:3-6.\nPryor WA. The antioxidant nutrients and disease prevention \u2013 What do we know and what do we need to find out? Am J Clin Nutr 1991;53 1 Suppl: 391S-3S.\nJanero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990;9:515-40.\nKornman KS. Mapping the pathogenesis of periodontitis: A new look. J Periodontol 2008;79 8 Suppl: 1560-8.\nCanak\u00e7i CF, Ci\u00e7ek Y, Canak\u00e7i V. Reactive oxygen species and human inflammatory periodontal diseases. Biochemistry (Mosc) 2005;70:619-28.\nDrisko CH. Nonsurgical periodontal therapy. Periodontol 2000 2001;25:77-88.\nCobb CM. Clinical significance of non-surgical periodontal therapy: An evidence-based perspective of scaling and root planing. J Clin Periodontol 2002;29 Suppl 2:6-16.\nPradeep AR, Agarwal E, Bajaj P, Rao NS. 4-Hydroxy-2-nonenal, an oxidative stress marker in crevicular fluid and serum in type 2 diabetes with chronic periodontitis. Contemp Clin Dent 2013;4:281-5.\nKonopka T, Kr\u00f3l K, Kopec W, Gerber H. Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch Immunol Ther Exp (Warsz) 2007;55:417-22.\nSingh N, Chander Narula S, Kumar Sharma R, Tewari S, Kumar Sehgal P. Vitamin E supplementation, superoxide dismutase status, and outcome of scaling and root planing in patients with chronic periodontitis: A randomized clinical trial. J Periodontol 2014;85:242-9.\nPatel SP, Rao NS, Pradeep AR. Effect of nonsurgical periodontal therapy on crevicular fluid and serum glutathione peroxidase levels. Dis Markers 2012;32:1-7.\nAkalin FA, Baltacioglu E, Alver A, Karabulut E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol 2007;34:558-65.\nTrivedi S, Lal N, Mahdi AA, Mittal M, Singh B, Pandey S. Evaluation of antioxidant enzymes activity and malondialdehyde levels in patients with chronic periodontitis and diabetes mellitus. J Periodontol 2014;85:713-20.\nBaltacioglu E, Yuva P, Aydin G, Alver A, Kahraman C, Karabulut E, et al. Lipid peroxidation levels and total oxidant\/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. Oxidative stress index: A new biomarker for periodontal disease? J Periodontol 2014;85:1432-41.\nChandra RV, Prabhuji ML, Roopa DA, Ravirajan S, Kishore HC. Efficacy of lycopene in the treatment of gingivitis: A randomised, placebo-controlled clinical trial. Oral Health Prev Dent 2007;5:327-36.\nArora N, Avula H, Avula JK. The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: A short-term evaluation. Quintessence Int 2013;44:395-405.\nAziz AS, Kalekar MG, Benjamin T, Suryakar AN, Prakashan MM, Bijle MN. Effect of nonsurgical periodontal therapy on some oxidative stress markers in patients with chronic periodontitis: A biochemical study. World J Dent 2013;4:17-23.\nNguyen TT, Ngo LQ, Promsudthi A, Surarit R. Salivary lipid peroxidation in patients with generalized chronic periodontitis and acute coronary syndrome. 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