{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:30:54Z","timestamp":1788345054341,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Androl"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/1008-682x.160886","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T06:50:45Z","timestamp":1436943045000},"page":"791","source":"Crossref","is-referenced-by-count":4,"title":["Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats"],"prefix":"10.4103","volume":"18","author":[{"given":"Dan-Hua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1008-682X.160886-1","first-page":"145","volume-title":"Male contraception: history and development","author":"Kogan","year":"2014","journal-title":"Urol Clin North Am"},{"key":"key-10.4103\/1008-682X.160886-2","first-page":"520","volume-title":"Hormonal approaches to male contraception","author":"Wang","year":"2010","journal-title":"Curr Opin Urol"},{"key":"key-10.4103\/1008-682X.160886-3","first-page":"1910","volume-title":"Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men","author":"Gu","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.160886-4","first-page":"2005","volume-title":"Norethisterone enanthate plus testosterone undecanoate for male contraception: effects of various injection intervals on spermatogenesis, reproductive hormones, testis, and prostate","author":"Meriggiola","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.160886-5","first-page":"562","volume-title":"A multicenter contraceptive efficacy study of injectable testosterone undecanoate in healthy Chinese men","author":"Gu","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.160886-6","first-page":"291","volume-title":"More than eight years\u2032 hands-on experience with the novel long-acting parenteral testosterone undecanoate","author":"Saad","year":"2007","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.160886-7","first-page":"757","volume-title":"Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men","author":"Nieschlag","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.4103\/1008-682X.160886-8","first-page":"342","volume-title":"Feasibility of poly (\u03f5-caprolactone-co-DL-lactide) as a biodegradable material for in situ forming implants: evaluation of drug release and in vivo degradation","author":"Zhang","year":"2015","journal-title":"Drug Dev Ind Pharm"},{"key":"key-10.4103\/1008-682X.160886-9","first-page":"3800","volume-title":"Biodegradation of in situ-forming gel of poly (DLLA-co-CL) in vivo","author":"Zhang","year":"2013","journal-title":"J Appl Polym Sci"},{"key":"key-10.4103\/1008-682X.160886-10","first-page":"5","volume-title":"The morphology of apoptosis","author":"Hacker","year":"2000","journal-title":"Cell Tissue Res"},{"key":"key-10.4103\/1008-682X.160886-11","first-page":"528","volume-title":"Morphologic and biochemical hallmarks of apoptosis","author":"Saraste","year":"2000","journal-title":"Cardiovasc Res"},{"key":"key-10.4103\/1008-682X.160886-12","first-page":"405","volume-title":"Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial","author":"Anawalt","year":"2005","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.160886-13","first-page":"301","volume-title":"Effect of chronic administration of 7alpha-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata)","author":"Ramachandra","year":"2002","journal-title":"Reproduction"},{"key":"key-10.4103\/1008-682X.160886-14","first-page":"126","volume-title":"Male hormonal contraception","author":"Roth","year":"2012","journal-title":"Virtual Mentor"},{"key":"key-10.4103\/1008-682X.160886-15","unstructured":"van Roijen JH. Basic Studies in Andrology: Spermatogenesis and Sperm Maturation in Rodents and Men [Ph.D. thesis]: Erasmus University Rotterdam; 1999."},{"key":"key-10.4103\/1008-682X.160886-16","doi-asserted-by":"crossref","unstructured":"Hikim AP, Maiti BR, Ghosh A. Spermatogenesis in the bandicoot rat. I. Duration of the cycle of the seminiferous epithelium. Arch Androl 1985; 14: 151-4.","DOI":"10.3109\/01485018508988291"},{"key":"key-10.4103\/1008-682X.160886-17","first-page":"1503","volume-title":"The effects of exogenous testosterone on sexuality and mood of normal men","author":"Anderson","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.160886-18","first-page":"282","volume-title":"Effects of chronic testosterone administration in normal men: safety and efficacy of high dosage testosterone and parallel dose-dependent suppression of luteinizing hormone, follicle-stimulating hormone, and sperm production","author":"Matsumoto","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.160886-19","first-page":"945","volume-title":"Effects of testosterone on spermatogenic cell populations in the adult rat","author":"McLachlan","year":"1994","journal-title":"Biol Reprod"},{"key":"key-10.4103\/1008-682X.160886-20","first-page":"207","volume-title":"Reversible effect of testosterone undecanoate injection on spermatogenesis in rats","author":"Wen","year":"2000","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.160886-21","first-page":"684","volume-title":"Higher testosterone dose impairs sperm suppression induced by a combined androgen-progestin regimen","author":"Meriggiola","year":"2002","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.160886-22","first-page":"931","volume-title":"Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen","author":"Coviello","year":"2004","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.160886-23","first-page":"2566","volume-title":"Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception","author":"Oduwole","year":"2014","journal-title":"FASEB J"},{"key":"key-10.4103\/1008-682X.160886-24","first-page":"853","volume-title":"Pharmacokinetics of testosterone undecanoate injected alone or in combination with norethisterone enanthate in healthy men","author":"Qoubaitary","year":"2006","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.160886-25","first-page":"289","volume-title":"Histological changes of the testis and epididymis in adult rats as a result of Leydig cell destruction after ethane dimethane sulfonate treatment: a morphometric study","author":"Yang","year":"2006","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.160886-26","first-page":"291","volume-title":"Quantitative (stereological) study of incomplete spermatogenic suppression induced by testosterone undecanoate injection in rats","author":"Yang","year":"2004","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.160886-27","first-page":"155","volume-title":"Studies on apoptosis of spermatogenic cells in normal fertile men treated with supraphysiological doses of testosterone undecanoate","author":"Ge","year":"1999","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.160886-28","unstructured":"Cao XW, Li HJ, Bai WJ. Seminal exfoliative cytology and testicular histopathology. Beijing: Peking University Medical Press; 2011. p. 73."},{"key":"key-10.4103\/1008-682X.160886-29","first-page":"1284","volume-title":"Stereological evaluation of human spermatogenesis after suppression by testosterone treatment: heterogeneous pattern of spermatogenic impairment","author":"Zhengwei","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.160886-30","first-page":"139","volume-title":"Acute and specific impairment of spermatogonial development by GnRH antagonist-induced gonadotrophin withdrawal in the adult macaque (Macaca fascicularis)","author":"Zhengwei","year":"1998","journal-title":"J Reprod Fertil"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:22Z","timestamp":1786649902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1008-682X.160886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016]]}},"alternative-id":["160886"],"URL":"https:\/\/doi.org\/10.4103\/1008-682x.160886","relation":{},"ISSN":["1008-682X"],"issn-type":[{"value":"1008-682X","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}