{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:04:17Z","timestamp":1790006657930,"version":"4.0.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is known on dental side effects over the course of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This prospective case-control study aimed to evaluate the oral adverse effects of isotretinoin in Turkish patients with acne vulgaris; compare oral conditions between patients and normal controls; and investigate the association between salivary parameters and International Caries Detection and Assessment System (ICDAS) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      For 6 months, the patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45) received isotretinoin daily (0.5 mg\/kg). The age-matched untreated controls (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45) were patients without acne. Both groups were examined before the study and at 6 months for salivary flow, buffer capacity, microbiologic tests, and caries status (based on the ICDAS). Salivary parameters and ICDAS scores were analyzed by Spearman's rank correlations. Data were statistically analyzed by the Mann\u2013Whitney U test, Wilcoxon signed rank tests, and McNemar's Chi-square tests (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-two isotretinoin-treated patients and 18 controls completed the study. At baseline, the groups were not significantly different in the evaluated parameters (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). At 6 months in the isotretinoin-treated group, salivary flow and buffer capacity significantly decreased, and the ICDAS scores significantly increased (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The changes in these criteria from baseline were insignificant in the controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). Intraoral pathogen counts were not significantly different between the groups, compared to baseline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). Stimulated salivary parameters in both groups were not correlated significantly with the ICDAS scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Isotretinoin significantly affected salivary flow, buffer capacity, caries lesion activity scores for 6 months. However, salivary parameters and caries lesion activity scores had no significant correlations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1119-3077.183248","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T07:45:48Z","timestamp":1465285548000},"page":"860-866","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["The Oral Adverse Effects of Isotretinoin Treatment in Acne Vulgaris Patients: A Prospective, Case\u2013control Study"],"prefix":"10.4103","volume":"20","author":[{"given":"U","family":"Erdemir","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Okan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical Park Bahcelievler Hospital, Bahcelievler, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Gungor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okmeydani Training and Research Hospital, Sisli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Tekin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Marmara University, Pendik, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SO","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8,8]]},"reference":[{"key":"R1-20251006","article-title":"Acne vulgaris","volume":"2008","author":"Purdy","year":"2008","journal-title":"BMJ Clin Evid"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(11)60321-8","article-title":"Acne vulgaris","volume":"379","author":"Williams","year":"2012","journal-title":"Lancet"},{"key":"R3-20251006","first-page":"CD002086","article-title":"Minocycline for acne vulgaris: Efficacy and safety","volume":"8","author":"Garner","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaad.2014.02.031","article-title":"A retrospective analysis of the duration of oral antibiotic therapy for the treatment of acne among adolescents: Investigating practice gaps and potential cost-savings","volume":"71","author":"Lee","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1601-0825.2003.03967.x","article-title":"Drug effects on salivary glands: Dry mouth","volume":"9","author":"Scully","year":"2003","journal-title":"Oral Dis"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2133.1991.tb06071.x","article-title":"Effect of oral isotretinoin therapy on saliva volume and composition","volume":"125","author":"Reynolds","year":"1991","journal-title":"Br J Dermatol"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/00016359509006003","article-title":"Systemic oral isotretinoin therapy and flow rate, pH, and matrix metalloproteinase-9 activity of stimulated saliva","volume":"53","author":"Oikarinen","year":"1995","journal-title":"Acta Odontol Scand"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000099586","article-title":"Reduced salivary flow induced by systemic isotretinoin may lead to dental decay. 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