{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:09Z","timestamp":1786649889142,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>\n                      Intracytoplasmic sperm injection (ICSI) currently helps many couples with male infertility. However, ICSI procedure may cause asynchronous sperm decondensation. This could introduce a risk for aneuploidy. The ICSI technique also could cause damage to the second meiotic spindle during injection and cause significantly abnormal pairing of chromosomes when compared with\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      fertilization (IVF). In this study, we have examined whether ICSI has a higher incidence of aneuploidy when compared with IVF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>A retrospective study was conducted on 36 individuals. Common numbers of chromosome abnormalities were detected using fluorescent in-situ hybridization (FISH). Seven probes were used to detect chromosome X, Y, 13, 16, 18, 21, and 22. Chi-square test was used for statistical analysis and presented as odd ratios with confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The age range was 26 through 44 (mean age 35.5) for IVF and 25 through 46 (mean age 35.8) for ICSI. From the 36 egg retrievals, 57 embryos were obtained from nine individuals using IVF and 183 embryos were obtained from 27 individuals using ICSI. For the IVF group, 37 of the 57 examined embryos were abnormal (65%), whereas 128 of 183 examined embryos were abnormal for the ICSI group (69.9%). Among the 57 embryos from the IVF cases, the number of absolute abnormal chromosomes were as follows: X&amp;Y chromosomes: 4 (12.9%), chromosome 13: 9 (29%), chromosome 16: 7 (22.5%), chromosome 18: 6 (19.3%), chromosome 21: 8 (25.8%), chromosome 22: 10 (32.2%). For the ICSI embryos: X and Y chromosomes: 18 (14%), chromosome 13: 34 (26.5%), chromosome 16: 23 (18%), chromosome 18: 23 (18%), chromosome 21: 26 (20.3%), chromosome 22: 31 (24.2%). The odds ratios for the difference between IVF and ICSI for each chromosome were as follows: X&amp;Y chromosomes: 1.53 (0.598-3.916), chromosome 13: 0.969 (0.443-2.122), chromosome 16: 0.709 (0.307-1.639), chromosome 18: 1.650 (0.650-4.188), chromosome 21: 0.777 (0.350-1.724), chromosome 22: 0.647 (0.311-1.348). Overall no significant difference between two insemination procedures was seen 0.948 (0.678-1.324).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>As a result; ICSI does not create a significantly higher aneuploidy number when compared with IVF as examined by FISH analysis of seven chromosome pairs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1119-3077.208959","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T23:31:48Z","timestamp":1499124708000},"page":"652-658","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["To Compare Aneuploidy Rates Between ICSI and IVF Cases"],"prefix":"10.4103","volume":"20","author":[{"given":"L","family":"Sahin","sequence":"first","affiliation":[{"name":"Department in Obstetrics and Gynecology, Kafkas University School of Medicine, Kars, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department in Obstetrics and Gynecology, Sakarya University School of Medicine, Sakarya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department in Histology and Embryology, In\u00f6n\u00fc University School of Medicine, Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"G\u00fcrel","sequence":"additional","affiliation":[{"name":"Department in Histology and Embryology, HRS Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Cal\u0131skan","sequence":"additional","affiliation":[{"name":"Department in Obstetrics and Gynecology, Bahcesehir University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,6,27]]},"reference":[{"key":"R1-20251006","first-page":"005291","article-title":"Preimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in vitro fertilisation or intracytoplasmic sperm injection","author":"Twisk","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s004390050443","article-title":"Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients","volume":"99","author":"Delhanty","year":"1997","journal-title":"Hum Genet"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1472-6483(10)61146-7","article-title":"Buendia FISH screening of aneuploidies in preimplantation embryos to improve IVF outcome","volume":"11","author":"Rubio","year":"2005","journal-title":"Reprod Biomed Online"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S1472-6483(10)61598-2","article-title":"The use of primates as models for assisted reproduction","volume":"5","author":"Hewitson","year":"2002","journal-title":"Reprod Biol Med Online"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0015-0282(16)57739-5","article-title":"Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities","volume":"64","author":"Munne","year":"1995","journal-title":"Fertil Steril"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.fertnstert.2005.06.041","article-title":"Frequency of chromosomal abnormalities in spontaneous abortions derived from intracytoplasmic sperm injection compared with those from in vitro fertilization","volume":"85","author":"Ma","year":"2006","journal-title":"Fertil Steril"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.fertnstert.2003.09.065","article-title":"Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection","volume":"8","author":"Lathi","year":"2004","journal-title":"Fertil Steril"},{"key":"R8-20251006","first-page":"36","article-title":"National Institute for Health and Clinical ExcellenceAssessment and treatment for people with fertility problems. 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