{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:49:36Z","timestamp":1786718976410,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Niger J Clin Pract"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/1119-3077.269019","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T02:33:29Z","timestamp":1571020409000},"page":"1319","source":"Crossref","is-referenced-by-count":13,"title":["Roles of UGT2B7 C802T gene polymorphism on the efficacy of morphine treatment on cancer pain among the Chinese han population"],"prefix":"10.4103","volume":"22","author":[{"given":"Y","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1119-3077.269019-1","first-page":"3687","volume-title":"Troublesome symptoms in cancer survivors: Fatigue, insomnia, neuropathy, and pain","author":"Pachman","year":"2012","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1119-3077.269019-2","first-page":"327","volume-title":"The association of depression and pain with health-related quality of life, disability, and health care use in cancer patients","author":"Kroenke","year":"2010","journal-title":"J Pain Symptom Manage"},{"key":"key-10.4103\/1119-3077.269019-3","first-page":"1585","volume-title":"Morphine sulfate extended-release capsules for the treatment of chronic, moderate-to-severe pain","author":"Nicholson","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"key-10.4103\/1119-3077.269019-4","first-page":"412","volume-title":"Pharmacological management of cancer-related pain","author":"Prommer","year":"2015","journal-title":"Cancer Control"},{"key":"key-10.4103\/1119-3077.269019-5","first-page":"1261","volume-title":"Morphine glucuronidation and elimination in intensive care patients: A Comparison with healthy volunteers","author":"Ahlers","year":"2015","journal-title":"Anesth Analg"},{"key":"key-10.4103\/1119-3077.269019-6","first-page":"30","volume-title":"A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development","author":"Oda","year":"2015","journal-title":"Drug Metab Pharmacokinet"},{"key":"key-10.4103\/1119-3077.269019-7","first-page":"3655","volume-title":"First-pass metabolism via UDP-glucuronosyltransferase: A barrier to oral bioavailability of phenolics","author":"Wu","year":"2011","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/1119-3077.269019-8","first-page":"977","volume-title":"UDP-glucuronosyltransferases 1A6 and 1A9 are the major isozymes responsible for the 7-O-glucuronidation of esculetin and 4-methylesculetin in human liver microsomes","author":"Zhu","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"key-10.4103\/1119-3077.269019-9","first-page":"283","volume-title":"Opioids bind to the amino acids 84 to 118 of UDP-glucuronosyltransferase UGT2B7","author":"Coffman","year":"2003","journal-title":"Mol Pharmacol"},{"key":"key-10.4103\/1119-3077.269019-10","first-page":"404","volume-title":"Reverse of acute and chronic morphine tolerance by lithocholic acid via down-regulating UGT2B7","author":"Yang","year":"2016","journal-title":"Front Pharmacol"},{"key":"key-10.4103\/1119-3077.269019-11","first-page":"423","volume-title":"Influence of UGT2B7, OPRM1 and ABCB1 gene polymorphisms on postoperative morphine consumption","author":"Bastami","year":"2014","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"key-10.4103\/1119-3077.269019-12","first-page":"309","volume-title":"Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients","author":"Fitzgibbon","year":"2003","journal-title":"Pain"},{"key":"key-10.4103\/1119-3077.269019-13","doi-asserted-by":"crossref","unstructured":"Lee J, Lakha SF, Mailis A. Efficacy of low-dose oral liquid morphine for elderly patients with chronic non-cancer pain: Retrospective chart review. Drugs Real World Outcomes 2015;2:369-76.","DOI":"10.1007\/s40801-015-0048-z"},{"key":"key-10.4103\/1119-3077.269019-14","doi-asserted-by":"crossref","unstructured":"Reyes-Gibby CC, Shete S, Rakv\u00e5g T, Bhat SV, Skorpen F, Bruera E, et al. Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene. Pain 2007;130:25-30.","DOI":"10.1016\/j.pain.2006.10.023"},{"key":"key-10.4103\/1119-3077.269019-15","first-page":"1","volume-title":"Morphine metabolism, transport and brain disposition","author":"De","year":"2012","journal-title":"Metab Brain Dis"},{"key":"key-10.4103\/1119-3077.269019-16","first-page":"559","volume-title":"Association of ABCB1\/MDR1 and OPRM1 gene polymorphisms with morphine pain relief","author":"Campa","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"key-10.4103\/1119-3077.269019-17","first-page":"799","volume-title":"The impact of CYP2D6 genetic polymorphisms on postoperative morphine consumption","author":"Candiotti","year":"2009","journal-title":"Pain Med"},{"key":"key-10.4103\/1119-3077.269019-18","first-page":"1232","volume-title":"The 118 A &gt ; G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease","author":"Klepstad","year":"2004","journal-title":"Acta Anaesthesiol Scand"},{"key":"key-10.4103\/1119-3077.269019-19","first-page":"200","volume-title":"UGT2B7 promoter variant -840G and gt; A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease","author":"Darbari","year":"2008","journal-title":"Am J Hematol"},{"key":"key-10.4103\/1119-3077.269019-20","first-page":"683","volume-title":"Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene","author":"Innocenti","year":"2008","journal-title":"Pharmacogenet Genomics"},{"key":"key-10.4103\/1119-3077.269019-21","first-page":"1048","volume-title":"Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population","author":"Saeki","year":"2004","journal-title":"Drug Metab Dispos"}],"container-title":["Nigerian Journal of Clinical Practice"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:42:14Z","timestamp":1786714934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1119-3077.269019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019]]}},"alternative-id":["269019"],"URL":"https:\/\/doi.org\/10.4103\/1119-3077.269019","relation":{},"ISSN":["1119-3077"],"issn-type":[{"value":"1119-3077","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}