{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:34:38Z","timestamp":1694597678332},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":1707,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP). Materials and Methods: Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6th and the 9th month after the surgery. Results: Except plaque index, all clinical parameters improved following surgery (P &lt; 0.05). The volume of GCF diminished from baseline to follow-up periods (P &lt; 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF. Conclusion: DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting.<\/jats:p>","DOI":"10.4103\/1305-7456.149644","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T06:54:47Z","timestamp":1421736887000},"page":"060-065","source":"Crossref","is-referenced-by-count":6,"title":["Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy"],"prefix":"10.1055","volume":"09","author":[{"given":"Ebru Olgun","family":"Erdemir","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem Karsiyaka","family":"Hendek","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Gencay","family":"Keceli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dentistry, Hacettepe University, S\u0131hhiye, Ankara, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teoman Z.","family":"Apan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, Kirikkale University, Merkez, Kirikkale, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"key-10.4103\/1305-7456.149644-1","first-page":"403","volume-title":"Effect of autogenous cortical bone grafting in conjunction with guided tissue regeneration in the treatment of intraosseous periodontal defects","author":"Keles","year":"2010","journal-title":"Eur J Dent","ISSN":"http:\/\/id.crossref.org\/issn\/1305-7456","issn-type":"print"},{"key":"key-10.4103\/1305-7456.149644-2","first-page":"E382","volume-title":"Periodontal regeneration in clinical practice","author":"Alpiste","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"key-10.4103\/1305-7456.149644-3","first-page":"60","volume-title":"Pathogenesis of periodontitis: Role of cytokines in host response","author":"Deo","year":"2010","journal-title":"Dent Today"},{"key":"key-10.4103\/1305-7456.149644-4","first-page":"514","volume-title":"Epidermal interleukin 1 alpha functional activity and interleukin 8 immunoreactivity are increased in patients with cutaneous T-cell lymphoma","author":"Lawlor","year":"1992","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/1305-7456.149644-5","first-page":"279","volume-title":"Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria","author":"Yoshimura","year":"1997","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/1305-7456.149644-6","first-page":"456","volume-title":"The role of interleukin-8 in inflammation and mechanisms of regulation","author":"Bickel","year":"1993","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-7","first-page":"135","volume-title":"Interleukin-17 regulates expression of the CXC chemokine LIX\/CXCL5 in osteoblasts: Implications for inflammation and neutrophil recruitment","author":"Ruddy","year":"2004","journal-title":"J Leukoc Biol"},{"key":"key-10.4103\/1305-7456.149644-8","first-page":"2106","volume-title":"IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger","author":"Ferretti","year":"2003","journal-title":"J Immunol"},{"key":"key-10.4103\/1305-7456.149644-9","first-page":"369","volume-title":"The potential role of interleukin-17 in the immunopathology of periodontal disease","author":"Takahashi","year":"2005","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.149644-10","first-page":"754","volume-title":"High levels of soluble intercellular adhesion molecule-1 (ICAM-1) in crevicular fluid of periodontitis patients with plaque","author":"Mol\u00e9","year":"1998","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.149644-11","first-page":"146","volume-title":"Inhibition of LFA-1\/ICAM-1 and VLA-4\/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases","author":"Yusuf-Makagiansar","year":"2002","journal-title":"Med Res Rev"},{"key":"key-10.4103\/1305-7456.149644-12","first-page":"425","volume-title":"Adhesion receptors of the immune system","author":"Springer","year":"1990","journal-title":"Nature"},{"key":"key-10.4103\/1305-7456.149644-13","first-page":"83","volume-title":"Circulating ICAM-1 isoforms: Diagnostic prospects for inflammatory and immune disorders","author":"Seth","year":"1991","journal-title":"Lancet"},{"key":"key-10.4103\/1305-7456.149644-14","first-page":"1233","volume-title":"Expression of extracellular matrix macromolecules around demineralized freeze-dried bone allografts","author":"Xiao","year":"1996","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-15","first-page":"478","volume-title":"Commercially-prepared allograft material has biological activity in vitro","author":"Shigeyama","year":"1995","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-16","first-page":"1","volume-title":"Development of a classification system for periodontal diseases and conditions","author":"Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"key-10.4103\/1305-7456.149644-17","unstructured":"Loe H, Silness J. 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Acta Odontol Scand 1964;22:121-35.","DOI":"10.3109\/00016356408993968"},{"key":"key-10.4103\/1305-7456.149644-19","first-page":"72","volume-title":"How effective is surgical therapy compared with nonsurgical debridement?","author":"Heitz-Mayfield","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/1305-7456.149644-20","first-page":"6","volume-title":"Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects","author":"Sumer","year":"2013","journal-title":"Eur J Dent","ISSN":"http:\/\/id.crossref.org\/issn\/1305-7456","issn-type":"print"},{"key":"key-10.4103\/1305-7456.149644-21","first-page":"967","volume-title":"The use of platelet-rich plasma combined with demineralized freeze-dried bone allograft in the treatment of periodontal endosseous defects: A report of two clinical cases","author":"Markou","year":"2010","journal-title":"J Am Dent Assoc"},{"key":"key-10.4103\/1305-7456.149644-22","first-page":"797","volume-title":"Inflammatory mediator release following bone grafting in humans: A pilot study","author":"Preston","year":"2007","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.149644-23","first-page":"1","volume-title":"Glycosaminoglycans in gingival crevicular fluid of patients with periodontal class II furcation involvement before and after guided tissue regeneration.A pilot study","author":"Yan","year":"2000","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-24","first-page":"527","volume-title":"Changes in transforming growth factor-beta1 in gingival crevicular fluid following periodontal surgery","author":"Kuru","year":"2004","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.149644-25","first-page":"757","volume-title":"GCF levels of MMP-3 and MMP-8 following placement of bioresorbable membranes","author":"Said","year":"1999","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.149644-26","first-page":"1535","volume-title":"Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment","author":"Gamonal","year":"2000","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-27","first-page":"452","volume-title":"Subantimicrobial-dose doxycycline and cytokine-chemokine levels in gingival crevicular fluid","author":"Emingil","year":"2011","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-28","first-page":"521","volume-title":"Equivalence and superiority testing in regeneration clinical trials","author":"Gunsolley","year":"1998","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.149644-29","first-page":"164","volume-title":"Infectious aspects of periodontal regeneration","author":"Slots","year":"2000","journal-title":"Periodontol"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1305-7456.149644.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T23:32:12Z","timestamp":1569281532000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1305-7456.149644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":29,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,9,4]]},"published-print":{"date-parts":[[2015,1]]}},"URL":"https:\/\/doi.org\/10.4103\/1305-7456.149644","relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}