{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:33:31Z","timestamp":1789763611325,"version":"4.0.1"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":1526,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: Although many studies reported more severe periodontal disease and the existing proinflammatory conditions in patients with diabetes but only few have examined the effect of type 2 diabetes mellitus (DM) on salivary matrix metalloproteinase-8 (MMP-8) level and other periodontal parameters. This study aims to evaluate the effect of type 2 DM on salivary MMP-8 levels and periodontal parameters, which might be useful in monitoring periodontal disease in diabetes. Materials and Methods: A total of 90 subjects were selected for the study and were divided into three groups: Group I included 30 healthy subjects; Group II included 30 subjects without type 2 DM but with chronic periodontitis, and Group III included 30 subjects with type 2 DM and chronic periodontitis. Periodontal parameters such as plaque index (PI), gingival index (GI), pocket probing depth (PPD), and clinical attachment level (CAL) were taken. The salivary MMP-8 level was estimated by Quantikine Human total MMP-8 immunoassay kit using ELISA method. Results: The mean value of the salivary MMP-8 of Group III was highest followed by Group II and Group I, the least. The other periodontal parameters PI, GI, PPD, CAL, was comparatively highest for Group III. Conclusion: This study suggests that diabetes is associated with an increased prevalence, extent, and severity of periodontitis. Furthermore, the increased levels of MMP-8 indicate the influence of diabetes on their salivary concentration.<\/jats:p>","DOI":"10.4103\/1305-7456.163222","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T06:54:39Z","timestamp":1440140079000},"page":"319-323","source":"Crossref","is-referenced-by-count":19,"title":["The influence of type 2 diabetes mellitus on salivary matrix metalloproteinase-8 levels and periodontal parameters: A study in an Indian population"],"prefix":"10.1055","volume":"09","author":[{"given":"Namita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, Dr. Z. A. Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narinder Dev","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, Dr. Z. A. Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lata","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Community Dentistry, Dr. Z. A. Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Tamil Nadu Government Medical College, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"key-10.4103\/1305-7456.163222-1","first-page":"11","volume-title":"Understanding the etiology of periodontitis: An overview of periodontal risk factors","author":"Nunn","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/1305-7456.163222-2","first-page":"478","volume-title":"Immunopathogenesis of chronic inflammatory periodontal disease: Cellular and molecular mechanisms","author":"Seymour","year":"1993","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/1305-7456.163222-3","first-page":"532","volume-title":"Type 2 diabetes mellitus and periodontal disease","author":"Shlossman","year":"1990","journal-title":"J Am Dent Assoc"},{"key":"key-10.4103\/1305-7456.163222-4","first-page":"127","volume-title":"Diabetes mellitus and periodontal disease","author":"Mealey","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/1305-7456.163222-5","first-page":"329","volume-title":"Periodontal disease.The sixth complication of diabetes mellitus","author":"L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"key":"key-10.4103\/1305-7456.163222-6","first-page":"S77","volume-title":"RAGE: A novel cellular receptor for advanced glycation end products","author":"Schmidt","year":"1996","journal-title":"Diabetes"},{"key":"key-10.4103\/1305-7456.163222-7","first-page":"311","volume-title":"MMP-mediated events in diabetes","author":"Ryan","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"key-10.4103\/1305-7456.163222-8","first-page":"21491","volume-title":"Matrix metalloproteinases","author":"Nagase","year":"1999","journal-title":"J Biol Chem"},{"key":"key-10.4103\/1305-7456.163222-9","first-page":"336","volume-title":"Risk factors and socioeconomic condition effects on periodontal and dental health: A pilot study among adults over 50 years of age","author":"Bertoldi","year":"2013","journal-title":"Eur J Dent","ISSN":"https:\/\/id.crossref.org\/issn\/1305-7456","issn-type":"print"},{"key":"key-10.4103\/1305-7456.163222-10","first-page":"217","volume-title":"Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions","author":"Wahlgren","year":"2001","journal-title":"J Pathol"},{"key":"key-10.4103\/1305-7456.163222-11","first-page":"72","volume-title":"Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas","author":"Moilanen","year":"2002","journal-title":"J Pathol"},{"key":"key-10.4103\/1305-7456.163222-12","first-page":"405","volume-title":"Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis","author":"Krupinski","year":"2007","journal-title":"Vasc Health Risk Manag"},{"key":"key-10.4103\/1305-7456.163222-13","first-page":"533","volume-title":"Indicators of periodontal disease activity: An evaluation","author":"Fine","year":"1986","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.163222-14","first-page":"52","volume-title":"Saliva as a diagnostic tool for periodontal disease: Current state and future directions","author":"Giannobile","year":"2000","journal-title":"Periodontol"},{"key":"key-10.4103\/1305-7456.163222-15","first-page":"121","volume-title":"Full-mouth profile of active MMP-8 in periodontitis patients","author":"Kraft-Neum\u00e4rker","year":"2012","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/1305-7456.163222-16","first-page":"306","volume-title":"Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation","author":"Sorsa","year":"2006","journal-title":"Ann Med"},{"key":"key-10.4103\/1305-7456.163222-17","first-page":"1387","volume-title":"Case definitions for use in population-based surveillance of periodontitis","author":"Page","year":"2007","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.163222-18","doi-asserted-by":"crossref","unstructured":"Silness J, Loe H. 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