{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:19:08Z","timestamp":1785543548876,"version":"3.56.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":1526,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: Single nucleotide polymorphisms (SNPs) in the promoter region of interleukin (IL)-10 gene, which codes for the anti-inflammatory cytokine IL-10, have been associated with its level of production in chronic periodontitis. The prevalence of promoter SNP genotypes is known in other populations with chronic periodontitis, while its association in the Indian population is not known. Hence, the present study was designed to investigate the prevalence of IL-10 promoter polymorphism in a racially defined group of Indians with severe chronic periodontitis as the Indian population is known to be genetically diverse. Materials and Methods: Genomic deoxyribonucleic acid was extracted from 46 nonsmoking patients with severe chronic periodontitis and 45 subjects with healthy periodontium. A SNP locus at \u22121087 of IL-10 was chosen, as this locus has been frequently associated with chronic periodontitis in other population. Genotyping was carried out using allele-specific polymerase chain reaction (AS-PCR), and the frequencies of genotype were analyzed between the groups. Results: The distribution of genotype and allele frequencies showed significant differences between the study groups. The prevalence of genotype AA alleles at \u22121087 locus of IL-10 was significantly higher in severe chronic periodontitis patients compared to the healthy controls (P = 0.05). Conclusion: The study has identified a positive association between the occurrence of AA allele at \u22121087 locus of IL-10 gene and severe chronic periodontitis in nonsmoking patients.<\/jats:p>","DOI":"10.4103\/1305-7456.163237","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T06:54:39Z","timestamp":1440140079000},"page":"387-393","source":"Crossref","is-referenced-by-count":11,"title":["Single nucleotide polymorphism at \u22121087 locus of interleukin-10 gene promoter is associated with severe chronic periodontitis in nonsmoking patients"],"prefix":"10.1055","volume":"09","author":[{"given":"Jasmine","family":"Crena","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayanand John","family":"Victor","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash Ponnudurai Samuel","family":"Gnana","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Principal Investigator, Applied Medical Genetics Division, Enable Biolabs, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"key-10.4103\/1305-7456.163237-1","first-page":"1","volume-title":"Host responses in the link between 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periodontitis","author":"Sumer","year":"2007","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.163237-17","first-page":"CR510","volume-title":"Analysis of-1082 IL-10 gene polymorphism in Iranian patients with generalized aggressive periodontitis","author":"Mellati","year":"2007","journal-title":"Med Sci Monit"},{"key":"key-10.4103\/1305-7456.163237-18","first-page":"1565","volume-title":"The broad effects of the functional IL-10 promoter-592 polymorphism: Modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome","author":"Claudino","year":"2008","journal-title":"J Leukoc Biol"},{"key":"key-10.4103\/1305-7456.163237-19","first-page":"517","volume-title":"Local expression of interleukin-10 and mCD14 in relation to the-1087 IL-10 and-159 CD14 gene polymorphisms in chronic periodontitis","author":"Donati","year":"2008","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.163237-20","first-page":"40","volume-title":"The 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