{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:02:28Z","timestamp":1790812948214,"version":"4.1.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":1526,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: The aim of the present study was to assess the expression of E-cad in oral precancerous lesions and conditions and oral carcinomas in comparison with normal mucosa. Materials and Methods: Total of 50 samples were selected for the study and were categorized into five groups and 10 samples in each group as Group I-oral leukoplakia (OL), Group II-oral lichen planus (OLP), Group III-oral submucous fibrosis (OSMF), Group IV-oral squamous cell carcinoma (OSCC) and Group V-normal oral mucosa (NOM) as control group. All the samples were assessed for the expression of E-cad by immunohistochemical study. Results: Upon assessing the expression of E-cad in OL, OSMF, OLP and OSCC, as majority of the samples with OSCC (90%), OL (80%), OLP (70%) and OSMF (60%) showed mild to moderate expression of E-cad staining, which was suggestive of reduction in dysplastic cells on comparison to NOM cells. This difference in expression and variation of E-cad upon comparison with normal mucosa was statistically significant (P &lt; 0.001). Conclusion: There is significant (P &lt; 0.001) variation of expression of E-cad with the histopathological dysplasia of the oral precancerous lesions and conditions, and the tumor differentiation of the oral cancers. However, there was no correlation of the degree of loss of expression of E-cad with the degree of dysplasia or the tumor differentiation of oral cancers. We conclude with our study that, there is a variation in the expression of E-cad but its value as a prognostic marker is questionable.<\/jats:p>","DOI":"10.4103\/1305-7456.163238","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T02:54:39Z","timestamp":1440125679000},"page":"364-372","source":"Crossref","is-referenced-by-count":37,"title":["Expression of E-cadherin in normal oral mucosa, in oral precancerous lesions and in oral carcinomas"],"prefix":"10.1055","volume":"09","author":[{"given":"Ugrappa","family":"Sridevi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Faculty of Dentistry, AIMST Dental Institute, AIMST University, Kedah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Dentistry, AIMST Dental Institute, AIMST University, Kedah, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velpula","family":"Nagalaxmi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugrappa Vijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Private Practitioner, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuti","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & Radiology, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"key-10.4103\/1305-7456.163238-1","first-page":"894","volume-title":"Assessment of malignant potential of oral submucous fibrosis through evaluation of p63, E-cadherin and CD105 expression","author":"Das","year":"2010","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/1305-7456.163238-2","first-page":"325","volume-title":"Oral cancer in India: An epidemiologic and clinical review","author":"Narayan","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"key-10.4103\/1305-7456.163238-3","unstructured":"Greenberg MS, Glick M. Burket's Oral Medicine. 11th ed. Hamilton: BC Decker Inc.; 2008."},{"key":"key-10.4103\/1305-7456.163238-4","first-page":"289","volume-title":"Cadherin and catenin biology represents a global mechanism for epithelial cancer mechanism","author":"Jankowski","year":"1997","journal-title":"J Clin Pathol Mol Pathol"},{"key":"key-10.4103\/1305-7456.163238-5","first-page":"992","volume-title":"E-cadherin-catenin cell-cell adhesion complex and human cancer","author":"Wijnhoven","year":"2000","journal-title":"Br J Surg"},{"key":"key-10.4103\/1305-7456.163238-6","first-page":"101","volume-title":"Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer","author":"Lipponen","year":"1994","journal-title":"J Pathol"},{"key":"key-10.4103\/1305-7456.163238-7","first-page":"58","volume-title":"Oral leukoplakia","author":"Rajendran","year":"2004","journal-title":"J Oral Maxillofac Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0973-029X","issn-type":"print"},{"key":"key-10.4103\/1305-7456.163238-8","first-page":"317","volume-title":"Potentially malignant disorders of the oral and oro-pharyngeal mucosa; terminology, classification and present concepts of management","author":"van","year":"2009","journal-title":"Oral Oncol"},{"key":"key-10.4103\/1305-7456.163238-9","first-page":"106","volume-title":"Oral submucous fibrosis: A clinico-histopathological study in Chennai","author":"Kiran","year":"2007","journal-title":"Indian J Dent Res","ISSN":"https:\/\/id.crossref.org\/issn\/0970-9290","issn-type":"print"},{"key":"key-10.4103\/1305-7456.163238-10","doi-asserted-by":"crossref","unstructured":"Andreasen JO. Oral lichen planus.1. A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol 1968;25:31-42.","DOI":"10.1016\/0030-4220(68)90194-1"},{"key":"key-10.4103\/1305-7456.163238-11","first-page":"153","volume-title":"Altered CD40 and E-cadherin expression \u2013 Putative role in oral lichen planus","author":"Neppelberg","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"key-10.4103\/1305-7456.163238-12","unstructured":"Robbins SL, Kumar V, Cotran RS. Basic Pathology. 7th ed. Philadelphia, U.S: Elsevier Publications; 2003 p. 165-211."},{"key":"key-10.4103\/1305-7456.163238-13","first-page":"189","volume-title":"The study of E-cadherine and CD44 immunoexpression in oral squamous cell carcinoma","author":"Simionescu","year":"2008","journal-title":"Rom J Morphol Embryol"},{"key":"key-10.4103\/1305-7456.163238-14","first-page":"1373","volume-title":"Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands","author":"Gibbons","year":"2001","journal-title":"Laryngoscope"},{"key":"key-10.4103\/1305-7456.163238-15","first-page":"303","volume-title":"E-cadherin expression in normal, hyperplastic and malignant oral epithelium","author":"Downer","year":"1993","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"key-10.4103\/1305-7456.163238-16","first-page":"288","volume-title":"The expression of E-cadherin and cathepsin-D in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: A comparative analysis between immunohistochemistry and routine histopathology","author":"Yogesh","year":"2011","journal-title":"J Oral Maxillofac Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0973-029X","issn-type":"print"},{"key":"key-10.4103\/1305-7456.163238-17","unstructured":"Rajendran R, Shivapathasundaram B, editors. Shafer's Textbook of Oral Pathology. 5th ed. New Delhi, India: Reed Elsevier India; 2006."},{"key":"key-10.4103\/1305-7456.163238-18","first-page":"191","volume-title":"Clinical profile and serum beta-carotene levels in oral submucous fibrosis","author":"Raina","year":"2005","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"key-10.4103\/1305-7456.163238-19","first-page":"347","volume-title":"Expression of E-cadherin in oral epithelial dysplasia and oral squamous cell carcinoma: An in vivo study","author":"Yuwanati","year":"2011","journal-title":"J Clin Exp Invest"},{"key":"key-10.4103\/1305-7456.163238-20","first-page":"997","volume-title":"Epithelial to mesenchymal transition (EMT) biomarkers \u2013 E-cadherin, beta-catenin, APC and Vimentin \u2013 In oral squamous cell carcinogenesis and transformation","author":"Chaw","year":"2012","journal-title":"Oral Oncol"},{"key":"key-10.4103\/1305-7456.163238-21","first-page":"e67361","volume-title":"Clinical significance of altered expression of \u00df-catenin and E-cadherin in oral dysplasia and cancer: Potential link with ALCAM expression","author":"Kaur","year":"2013","journal-title":"PLoS One"},{"key":"key-10.4103\/1305-7456.163238-22","first-page":"25","volume-title":"Role of iron deficiency in oral submucous fibrosis: An initiating or accelerating factor","author":"Ganapathy","year":"2011","journal-title":"J Indian Acad Oral Med Radiol","ISSN":"https:\/\/id.crossref.org\/issn\/0972-1363","issn-type":"print"},{"key":"key-10.4103\/1305-7456.163238-23","first-page":"1223","volume-title":"DNA content and Cyclooxygenase-2 as risk markers of cancer development in oral lichen planus","author":"Neppelberg","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"key-10.4103\/1305-7456.163238-24","first-page":"634","volume-title":"Decreased expression of the p63 related proteins beta-catenin, E-cadherin and EGFR in oral lichen planus","author":"Ebrahimi","year":"2008","journal-title":"Oral Oncol"},{"key":"key-10.4103\/1305-7456.163238-25","first-page":"369","volume-title":"Immunohistochemical study of desmosomes in oral squamous cell carcinoma: Correlation with cytokeratin and E-cadherin staining, and with tumour behaviour","author":"Shinohara","year":"1998","journal-title":"J Pathol"},{"key":"key-10.4103\/1305-7456.163238-26","first-page":"190","volume-title":"Reduced E-cadherin expression is an indicator of unfavourable prognosis in oral squamous cell carcinoma","author":"Diniz-Freitas","year":"2006","journal-title":"Oral Oncol"},{"key":"key-10.4103\/1305-7456.163238-27","first-page":"589","volume-title":"Differential expression of E-cadherin in metastatic lesions comparing to primary oral squamous cell carcinoma","author":"Hung","year":"2006","journal-title":"J Oral Pathol Med"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1305-7456.163238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T02:46:50Z","timestamp":1567651610000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1305-7456.163238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":27,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,9,4]]},"published-print":{"date-parts":[[2015,7]]}},"URL":"https:\/\/doi.org\/10.4103\/1305-7456.163238","relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}