{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:41:29Z","timestamp":1792622489549,"version":"4.5.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":1361,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: To evaluate the efficacy of coronally advanced flap (CAF) procedure under microsurgical approach for the management of Miller's Class I and II gingival recession defects with the use of either platelet-rich fibrin (PRF) or amnion membrane (AM) in comparison to CAF alone. Materials and Methods: A total of 45 sites with Miller's Class I or II gingival recession defect were randomly distributed for: Experimental Group I (CAF with PRF) sites (n = 15) which were treated with the microsurgical approach using CAF along with PRF; experimental Group II (CAF with AM) sites (n = 15) were treated with the microsurgical approach using CAF along with AM; control Group III (CAF alone) sites (n = 15) were treated with the microsurgical approach using CAF alone. Vertical gingival recession (VGR), horizontal gingival recession (HGR), gingival thickness (GT) (using transgingival probing [TGP] and ultrasonography [USG]) and patients\u2019 response and acceptance were documented at baseline, 3 months and 6 months after surgical interventions. Results: CAF alone and in combination with PRF or AM, were effective techniques for root coverage with average VGR values of 1.47 \u00b1 0.92 mm (56%), 0.67 \u00b1 1.23 mm (36%) and 0.60 \u00b1 1.06 mm (33%) in Group I (CAF with PRF), Group II (CAF with AM), and Group III (CAF alone), respectively. Complete coverage (100%) was obtained in 33.3% sites of Group I (CAF with PRF), 26.6% sites of Group II (CAF with AM) and 13.3% in Group III (CAF alone). Patients\u2019 response and acceptance for surgical treatment modality in terms of patient esthetic score and decrease in hypersensitivity score was highest for Group I (CAF with PRF), whereas patient comfort score was highest for Group II (CAF with AM). At 6 months follow-up, significant increase in GT measurements (using TGP and USG) in Group I (CAF with PRF), whereas, nonsignificant increase for Group II (CAF with AM) and no change or decrease for Group III (CAF alone) as compared to baseline was observed. Conclusion: The present study observed enhancement in root coverage when PRF or AM are used in conjunction with CAF as compared to CAF alone. These results are based on 6-month followup. Therefore, the long-term evaluation may be necessary to appreciate the clinical effect of autologous PRF and AM.<\/jats:p>","DOI":"10.4103\/1305-7456.175686","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T06:58:08Z","timestamp":1454569088000},"page":"121-133","source":"Crossref","is-referenced-by-count":54,"title":["Patient-centered evaluation of microsurgical management of gingival recession using coronally advanced flap with platelet-rich fibrin or amnion membrane: A comparative analysis"],"prefix":"10.1055","volume":"10","author":[{"given":"Sumit Kumar","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Jhingran","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Kumar","family":"Bains","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iram","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"key-10.4103\/1305-7456.175686-1","first-page":"1","volume-title":"Coronally advanced flap in the treatment of recession coverage","author":"Avinash","year":"2014","journal-title":"Int J Dent Case Rep"},{"key":"key-10.4103\/1305-7456.175686-2","first-page":"486","volume-title":"Guided tissue regeneration and a free gingival graft for the management of buccal recession: A case report","author":"Prato","year":"1993","journal-title":"Int J Periodontics Restorative Dent"},{"key":"key-10.4103\/1305-7456.175686-3","first-page":"631","volume-title":"A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller's class-I and II recession defects","author":"Padma","year":"2013","journal-title":"J Indian Soc Periodontol","ISSN":"https:\/\/id.crossref.org\/issn\/0972-124X","issn-type":"print"},{"key":"key-10.4103\/1305-7456.175686-4","first-page":"299","volume-title":"Platelet-rich fibrin (PRF): a second-generation platelet concentrate.Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift","author":"Choukroun","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"key-10.4103\/1305-7456.175686-5","first-page":"e45","volume-title":"Platelet-rich fibrin PRF: A second-generation platelet concentrate.Part II: Platelet-related biologic features","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"key-10.4103\/1305-7456.175686-6","first-page":"e51","volume-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate.Part III: Leucocyte activation: A new feature for platelet concentrates?","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"key-10.4103\/1305-7456.175686-7","first-page":"158","volume-title":"Classification of platelet concentrates: From pure platelet-rich plasma P-PRP to leucocyte- and platelet-rich fibrin L-PRF","author":"Dohan","year":"2009","journal-title":"Trends Biotechnol"},{"key":"key-10.4103\/1305-7456.175686-8","first-page":"e41","volume-title":"Use of platelet-rich fibrin membrane following treatment of gingival recession: A randomized clinical trial","author":"Jankovic","year":"2012","journal-title":"Int J Periodontics Restorative Dent"},{"key":"key-10.4103\/1305-7456.175686-9","first-page":"300","volume-title":"Concise review: Isolation and characterization of cells from human term placenta: Outcome of the first international workshop on placenta derived stem cells","author":"Parolini","year":"2008","journal-title":"Stem Cells"},{"key":"key-10.4103\/1305-7456.175686-10","first-page":"106","volume-title":"Amniotic membrane \u2013 A novel material for regeneration and repair","author":"Chopra","year":"2013","journal-title":"J Biomim Biomater Tissue Eng"},{"key":"key-10.4103\/1305-7456.175686-11","first-page":"124","volume-title":"A novel dehydrated amnion allograft for use in the treatment of gingival recession: An observational case series","author":"Gurinsky","year":"2009","journal-title":"J Implant Adv Clin Dent"},{"key":"key-10.4103\/1305-7456.175686-12","first-page":"721","volume-title":"Surgical microscope may enhance root coverage with subepithelial connective tissue graft: A randomized-controlled clinical trial","author":"Bittencourt","year":"2012","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.175686-13","first-page":"287","volume-title":"Coverage of localized gingival recessions: Comparison of micro- and macrosurgical techniques","author":"Burkhardt","year":"2005","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.175686-14","first-page":"428","volume-title":"The gingival biotype revisited: Transparency of the periodontal probe through the gingival margin as a method to discriminate thin from thick gingiva","author":"De","year":"2009","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.175686-15","first-page":"237","volume-title":"Gingival biotype assessment in the esthetic zone: Visual versus direct measurement","author":"Kan","year":"2010","journal-title":"Int J Periodontics Restorative Dent"},{"key":"key-10.4103\/1305-7456.175686-16","first-page":"828","volume-title":"Thickness of gingiva in association with age, gender and dental arch location","author":"Vandana","year":"2005","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.175686-17","first-page":"168","volume-title":"Root coverage: Comparison of coronally positioned flap with and without titanium-reinforced barrier membrane","author":"Lins","year":"2003","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.175686-18","doi-asserted-by":"crossref","unstructured":"Bains R, Bains VK, Loomba K, Verma K, Nasir A. Management of pulpal floor perforation and grade II Furcation involvement using mineral trioxide aggregate and platelet rich fibrin: A clinical report. Contemp Clin Dent 2012;3 Suppl 2:S223-7.","DOI":"10.4103\/0976-237X.101100"},{"key":"key-10.4103\/1305-7456.175686-19","first-page":"198","volume-title":"Comparison of platelet-rich plasma, bovine porous bone mineral, and guided tissue regeneration versus platelet-rich plasma and bovine porous bone mineral in the treatment of intrabony defects: A reentry study","author":"Lekovic","year":"2002","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.175686-20","first-page":"360","volume-title":"Understanding interobserver agreement: The kappa statistic","author":"Viera","year":"2005","journal-title":"Fam Med"},{"key":"key-10.4103\/1305-7456.175686-21","first-page":"747","volume-title":"Periodontal disease in pregnancy","author":"Silness","year":"1964","journal-title":"Acta Odontal Scand"},{"key":"key-10.4103\/1305-7456.175686-22","doi-asserted-by":"crossref","unstructured":"Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.","DOI":"10.3109\/00016356309011240"},{"key":"key-10.4103\/1305-7456.175686-23","first-page":"43","volume-title":"Transgingival probing and ultrasonographic methods for determination of gingival thickness \u2013 A comparative study","author":"Issrani","year":"2013","journal-title":"Adv Hum Biol"},{"key":"key-10.4103\/1305-7456.175686-24","first-page":"697","volume-title":"Examining the validity of pressure ulcer risk assessment scales: Developing and using illustrated patient simulations to collect the data","author":"Gould","year":"2001","journal-title":"J Clin Nurs"},{"key":"key-10.4103\/1305-7456.175686-25","first-page":"690","volume-title":"Root-dentin sensitivity following non-surgical periodontal treatment","author":"Tammaro","year":"2000","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.175686-26","first-page":"154","volume-title":"Platelet rich fibrin in the treatment of bilateral gingival recession","author":"Eren","year":"2012","journal-title":"Clinic Adv Periodontics"},{"key":"key-10.4103\/1305-7456.175686-27","first-page":"244","volume-title":"Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6-month study","author":"Aroca","year":"2009","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.175686-28","first-page":"137","volume-title":"Root coverage grafting comparing placental derived membrane to acellular dermis matrix: A case series","author":"Wallace","year":"2012","journal-title":"Dentistry"},{"key":"key-10.4103\/1305-7456.175686-29","first-page":"53","volume-title":"Treatment of gingival recessions by combined periodontal regenerative techniques, guided tissue regeneration, and subpedicle connective tissue grafts.A comparative clinical study","author":"Paolantonio","year":"2002","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.175686-30","first-page":"1","volume-title":"Comparative evaluation of platelet-rich fibrin membrane and connective tissue graft in the treatment of multiple adjacent recession defects: A clinical study","author":"Uraz","year":"2013","journal-title":"J Dent Sci"},{"key":"key-10.4103\/1305-7456.175686-31","first-page":"11","volume-title":"The use of platelet-rich fibrin membrane in gingival recession treatment","author":"Aleksic","year":"2010","journal-title":"Srp Arh Celok Lek"},{"key":"key-10.4103\/1305-7456.175686-32","first-page":"ZC04","volume-title":"Comparison of coronally advanced and semilunar coronally repositioned flap for the treatment of gingival recession","author":"Moka","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"key-10.4103\/1305-7456.175686-33","first-page":"368","volume-title":"Shallow localized gingival recession defects treated with modified coronally repositioned flap technique: A case series","author":"Akkaya","year":"2013","journal-title":"Eur J Dent","ISSN":"https:\/\/id.crossref.org\/issn\/1305-7456","issn-type":"print"},{"key":"key-10.4103\/1305-7456.175686-34","doi-asserted-by":"crossref","unstructured":"Kumar AP, Fernandes B, Surya C. Platelet rich fibrin: A promising approach for root coverage. J Interdiscip Dent 2011;1:115-8.","DOI":"10.4103\/2229-5194.85033"},{"key":"key-10.4103\/1305-7456.175686-35","first-page":"223","volume-title":"Platelet rich fibrin membrane for recession coverage","author":"Jadhav","year":"2012","journal-title":"E J Dent"},{"key":"key-10.4103\/1305-7456.175686-36","first-page":"102","volume-title":"Bilateral multiple recession coverage with platelet-rich fibrin in comparison with amniotic membrane","author":"Shetty","year":"2014","journal-title":"J Indian Soc Periodontol","ISSN":"https:\/\/id.crossref.org\/issn\/0972-124X","issn-type":"print"},{"key":"key-10.4103\/1305-7456.175686-37","first-page":"21","volume-title":"Coronally Positioned Flap for Root Coverage: Comparison between smokers and nonsmokers","author":"Nanavati","year":"2013","journal-title":"J Int Oral Health"},{"key":"key-10.4103\/1305-7456.175686-38","first-page":"100","volume-title":"Evaluation of intrabony defects treated with platelet-rich fibrin or autogenous bone graft: A comparative analysis","author":"Mathur","year":"2015","journal-title":"Eur J Dent","ISSN":"https:\/\/id.crossref.org\/issn\/1305-7456","issn-type":"print"},{"key":"key-10.4103\/1305-7456.175686-39","first-page":"23","volume-title":"Regenerative potential of platelet rich fibrin in dentistry: Literature review","author":"Gupta","year":"2011","journal-title":"Asian J Oral Health Allied Sci"},{"key":"key-10.4103\/1305-7456.175686-40","first-page":"135","volume-title":"Comparative assesment of gingival thickness using transgingival probing and ultrasonographic method","author":"Savitha","year":"2005","journal-title":"Indian J Dent Res","ISSN":"https:\/\/id.crossref.org\/issn\/0970-9290","issn-type":"print"},{"key":"key-10.4103\/1305-7456.175686-41","first-page":"478","volume-title":"Assessment of gingival thickness with regards to age, gender and arch location","author":"Kolte","year":"2014","journal-title":"J Indian Soc Periodontol","ISSN":"https:\/\/id.crossref.org\/issn\/0972-124X","issn-type":"print"},{"key":"key-10.4103\/1305-7456.175686-42","first-page":"295","volume-title":"Is surgical root coverage effective for the treatment of cervical dentin hypersensitivity.A systematic review?","author":"Douglas","year":"2013","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.175686-43","first-page":"839","volume-title":"Ultrasonic determination of gingival thickness.Subject variation and influence of tooth type and clinical features","author":"Eger","year":"1996","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.175686-44","first-page":"25","volume-title":"Accretion of gingival height by gingival thickness augmentation: A clinical report","author":"Bains","year":"2013","journal-title":"Asian J Oral Health Allied Sci"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1305-7456.175686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T23:01:58Z","timestamp":1569279718000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1305-7456.175686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":44,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2019,9,23]]},"published-print":{"date-parts":[[2016,1]]}},"URL":"https:\/\/doi.org\/10.4103\/1305-7456.175686","relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}