{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:11:39Z","timestamp":1773850299904,"version":"3.50.1"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":1088,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: Periostin is a matricellular protein highly expressed in periosteum, periodontal ligament and is essential for tissue integrity and maturation. It plays a role in collagen fibrillogenesis and is downregulated in periodontal disease. Biostimulation utilizing low-level laser therapy (LLLT) influences periodontal ligament fibroblast proliferation. This study was conducted with the objective of estimating periostin levels in chronic periodontitis (CP) patients following LLLT as an adjunct to root surface debridement (RSD). Materials and Methods: Thirty periodontally healthy participants (Group I) and sixty CP participants were recruited. Based on the therapeutic intervention, CP patients were allocated to either RSD (Group II) or to RSD with LLLT (Group III) group. Clinical parameters and gingival crevicular fluid (GCF) periostin levels were assessed at the baseline and at the 3rd month. Results: Periostin levels were significantly lower in CP patients when compared to healthy individuals at the baseline (P &lt; 0.01). Following nonsurgical periodontal treatment (NSPT), periostin levels significantly increased in both Group II and III, when compared to baseline values (P &lt; 0.001). Comparison of mean periostin levels between both the treatment groups showed a significant increase in LLLT group than RSD at the 3rd month (P &lt; 0.05). Conclusion: Within the limitations of the present study, LLLT application was found to have additional benefits over RSD with respect to clinical periodontal parameters and GCF periostin levels. Moreover, periostin may be used as a possible biomarker to evaluate the outcome following NSPT.<\/jats:p>","DOI":"10.4103\/1305-7456.195179","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T03:49:08Z","timestamp":1480909748000},"page":"546-550","source":"Crossref","is-referenced-by-count":28,"title":["Gingival crevicular fluid periostin levels in chronic periodontitis patients following nonsurgical periodontal treatment with low-level laser therapy"],"prefix":"10.1055","volume":"10","author":[{"given":"Dhanangchaayan","family":"Kumaresan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aruna","family":"Balasundaram","sequence":"additional","affiliation":[{"name":"Department of Periodontology, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanaja Krishna","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Periodontology, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deva Priya","family":"Appukuttan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"key-10.4103\/1305-7456.195179-1","first-page":"60","volume-title":"Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy","author":"Erdemir","year":"2015","journal-title":"Eur J Dent","ISSN":"https:\/\/id.crossref.org\/issn\/1305-7456","issn-type":"print"},{"key":"key-10.4103\/1305-7456.195179-2","first-page":"1239","volume-title":"Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta","author":"Horiuchi","year":"1999","journal-title":"J Bone Miner Res"},{"key":"key-10.4103\/1305-7456.195179-3","first-page":"3201","volume-title":"Periostin in fibrillogenesis for tissue regeneration: Periostin actions inside and outside the cell","author":"Kudo","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"key-10.4103\/1305-7456.195179-4","first-page":"1078","volume-title":"Periostin is down-regulated during periodontal inflammation","author":"Padial-Molina","year":"2012","journal-title":"J Dent Res"},{"key":"key-10.4103\/1305-7456.195179-5","first-page":"1480","volume-title":"Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice","author":"Rios","year":"2008","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.195179-6","first-page":"405","volume-title":"Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor \u2013 A and Porphyromonas gingivalis lipopolysaccharides","author":"Padial-Molina","year":"2014","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/1305-7456.195179-7","first-page":"694","volume-title":"Tumor necrosis factor-a and Porphyromonas gingivalis lipopolysaccharides decrease periostin in human periodontal ligament fibroblasts","author":"Padial-Molina","year":"2013","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.195179-8","first-page":"112","volume-title":"Initial effects of low-level laser therapy on growth and differentiation of human osteoblast-like cells","author":"Stein","year":"2008","journal-title":"Wien Klin Wochenschr"},{"key":"key-10.4103\/1305-7456.195179-9","first-page":"714","volume-title":"The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation","author":"Qadri","year":"2005","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.195179-10","first-page":"481","volume-title":"The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment","author":"Aykol","year":"2011","journal-title":"J Periodontol"},{"key":"key-10.4103\/1305-7456.195179-11","first-page":"437","volume-title":"ECM signalling: Orchestrating cell behaviour and misbehaviour","author":"Lukashev","year":"1998","journal-title":"Trends Cell Biol"},{"key":"key-10.4103\/1305-7456.195179-12","first-page":"695","volume-title":"Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues","author":"Norris","year":"2007","journal-title":"J Cell Biochem"},{"key":"key-10.4103\/1305-7456.195179-13","first-page":"593","volume-title":"Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes","author":"Yu","year":"1996","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/1305-7456.195179-14","first-page":"179","volume-title":"Comparison of the low level laser therapy effects on cultured human gingival fibroblasts proliferation using different irradiance and same fluence","author":"Almeida-Lopes","year":"2001","journal-title":"Lasers Surg Med"},{"key":"key-10.4103\/1305-7456.195179-15","first-page":"764","volume-title":"Preliminary insight into the periostin leverage during periodontal tissue healing","author":"Padial-Molina","year":"2015","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.195179-16","first-page":"986","volume-title":"Gingival crevicular fluid and salivary periostin levels in non-smoker subjects with chronic and aggressive periodontitis: Periostin levels in chronic and aggressive periodontitis","author":"Aral","year":"2016","journal-title":"Inflammation"},{"key":"key-10.4103\/1305-7456.195179-17","first-page":"707","volume-title":"Assessment of periostin levels in serum and gingival crevicular fluid of patients with periodontal disease","author":"Balli","year":"2015","journal-title":"J Periodontal Res"},{"key":"key-10.4103\/1305-7456.195179-18","first-page":"899","volume-title":"Association of red complex, A.actinomycetemcomitans and non-oral bacteria with periodontal diseases","author":"da","year":"2011","journal-title":"Arch Oral Biol"},{"key":"key-10.4103\/1305-7456.195179-19","first-page":"302","volume-title":"Treatment of periodontal pockets with a diode laser","author":"Moritz","year":"1998","journal-title":"Lasers Surg Med"},{"key":"key-10.4103\/1305-7456.195179-20","first-page":"59","volume-title":"Effect of low power diode laser 810 nm on TGF-\u03b21 level in GCF in aggressive periodontitis","author":"Saafan","year":"2013","journal-title":"J Dent Lasers","ISSN":"https:\/\/id.crossref.org\/issn\/2321-1385","issn-type":"print"},{"key":"key-10.4103\/1305-7456.195179-21","first-page":"29","volume-title":"Laser application in non-surgical periodontal therapy: A systematic review","author":"Schwarz","year":"2008","journal-title":"J Clin Periodontol"},{"key":"key-10.4103\/1305-7456.195179-22","first-page":"1393","volume-title":"Effectiveness of diode laser as adjunctive therapy to scaling root planning in the treatment of chronic periodontitis: A meta-analysis","author":"Sgolastra","year":"2013","journal-title":"Lasers Med Sci"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/1305-7456.195179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T19:04:27Z","timestamp":1569351867000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/1305-7456.195179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":22,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2019,9,24]]},"published-print":{"date-parts":[[2016,10]]}},"URL":"https:\/\/doi.org\/10.4103\/1305-7456.195179","relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]}}}