{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:08Z","timestamp":1787775668488,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Cryptococcus neoformans<\/jats:italic>\n                      is an opportunistic fungal infection affects predominately the central nervous system in HIV patients and patients with other immunocompromised states. It has rarely been described in immunocompetent patients. It is a serious infection with a high of mortality rate. We describe a case of a 48-year-old patient diagnosed with lupus nephritis treated with corticosteroids and mycophenolate mofetil who developed central nervous cryptococcosis complicated by septicemia. She died despite the use of antifungals. Cryptococcal infection is an uncommon, but often a fatal complication of systemic lupus erythematosus. Timely diagnosis and effective antifungal therapy could improve its prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1319-2442.220874","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T23:35:26Z","timestamp":1513640126000},"page":"1435-1439","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Disseminated Cryptococcosis as a Complication of Lupus Nephritis"],"prefix":"10.4103","volume":"28","author":[{"given":"Soumaya","family":"Beji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriam","family":"Hajji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanene","family":"El Kateb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Kosai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hela","family":"Jebali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Kheder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia Ben","family":"Fatma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Rais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Laameri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha","family":"Krid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Zouaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20260302","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1259\/bjr.74.877.740083","article-title":"Cerebral cryptococcosis: Atypical appearances on CT","volume":"74","author":"Awasthi","year":"2001","journal-title":"Br J Radiol"},{"key":"R2-28-20260302","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3201\/eid0401.980109","article-title":"What makes Cryptococcus neoformans a pathogen","volume":"4","author":"Buchanan","year":"1998","journal-title":"Emerg Infect Dis"},{"key":"R3-28-20260302","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijid.2014.05.033","article-title":"Severe meningoencephalitis co-infection due to Cryptococcus neoformans and Mycobacterium tuberculosis in a child with systemic lupus erythematosus","volume":"33","author":"Martinez-Longoria","year":"2015","journal-title":"Int J Infect Dis"},{"key":"R4-28-20260302","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1086\/587101","article-title":"When primary antifungal therapy fails","volume":"46","author":"Nucci","year":"2008","journal-title":"Clin Infect Dis"},{"key":"R5-28-20260302","doi-asserted-by":"crossref","first-page":"e2870","DOI":"10.1371\/journal.pone.0002870","article-title":"Major role for amphotericin B-flucytosine combination in severe cryptococcosis","volume":"3","author":"Dromer","year":"2008","journal-title":"PLoS One"},{"key":"R6-28-20260302","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0049-0172(92)90044-E","article-title":"Cryptococcal meningitis in systemic lupus erythematosus","volume":"22","author":"Zimmermann","year":"1992","journal-title":"Semin Arthritis Rheum"},{"key":"R7-28-20260302","first-page":"40","article-title":"Central nervous system infections in patients with systemic lupus erythematosus","volume":"32","author":"Hung","year":"2005","journal-title":"J Rheumatol"},{"key":"R8-28-20260302","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1052-5149(25)00441-1","article-title":"Neuroimaging of AIDS. 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