{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:29:09Z","timestamp":1787030949379,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi J Kidney Dis Transpl"],"published-print":{"date-parts":[[2020]]},"DOI":"10.4103\/1319-2442.284005","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:54:12Z","timestamp":1589000052000},"page":"312","source":"Crossref","is-referenced-by-count":5,"title":["Proton-pump inhibitors and chronic kidney disease: Hidden consequences of an inappropriate drug use?"],"prefix":"10.4103","volume":"31","author":[{"given":"Helmut","family":"Schiffl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Al-Nemnem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SusanneM","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1319-2442.284005-1","doi-asserted-by":"crossref","unstructured":"Katz MH. Failing the acid test: Benefits of proton pump inhibitors may not justify the risks for many users. Arch Intern Med 2010;170:747-8","DOI":"10.1001\/archinternmed.2010.64"},{"key":"key-10.4103\/1319-2442.284005-2","unstructured":"Littman J, Halil R. Potential effects of rational prescribing on national health care spending: More than half a billion dollars in annual savings. Can Fam Physician 2016;62:235-44"},{"key":"key-10.4103\/1319-2442.284005-3","doi-asserted-by":"crossref","unstructured":"Luo H, Fan Q, Xiao S, Chen K. Changes in proton pump inhibitor prescribing trend over the past decade and pharmacists\u2019 effect on prescribing practice at a tertiary hospital. BMC Health Serv Res 2018;18:537","DOI":"10.1186\/s12913-018-3358-5"},{"key":"key-10.4103\/1319-2442.284005-4","doi-asserted-by":"crossref","unstructured":"Naunton M, Peterson GM, Deeks LS, Young H, Kosari S. We have had a gutful: The need for deprescribing proton pump inhibitors. J Clin Pharm Ther 2018;43:65-72","DOI":"10.1111\/jcpt.12613"},{"key":"key-10.4103\/1319-2442.284005-5","doi-asserted-by":"crossref","unstructured":"Malfertheiner P, Kandulski A, Venerito M. Proton-pump inhibitors: Understanding the complications and risks. Nat Rev Gastroenterol Hepatol 2017;14:697-710","DOI":"10.1038\/nrgastro.2017.117"},{"key":"key-10.4103\/1319-2442.284005-6","doi-asserted-by":"crossref","unstructured":"Scarpignato C, Gatta L, Zullo A, Blandizzi C; SIF-AIGO-FIMMG Group, Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of General Practitioners. Effective and safe proton pump inhibitor therapy in acid- related diseases - A position paper addressing benefits and potential harms of acid suppression. BMC Med 2016;14:179","DOI":"10.1186\/s12916-016-0718-z"},{"key":"key-10.4103\/1319-2442.284005-7","doi-asserted-by":"crossref","unstructured":"Nehra AK, Alexander JA, Loftus CG, Nehra V. Proton pump inhibitors: Review of emerging concerns. Mayo Clin Proc 2018; 93:240-6","DOI":"10.1016\/j.mayocp.2017.10.022"},{"key":"key-10.4103\/1319-2442.284005-8","doi-asserted-by":"crossref","unstructured":"Savarino V, Marabotto E, Zentilin P, Furnari M, Bodini G, De Maria C, et al. Proton pump inhibitors: Use and misuse in the clinical setting. Expert Rev Clin Pharmacol 2018;11: 1123-34","DOI":"10.1080\/17512433.2018.1531703"},{"key":"key-10.4103\/1319-2442.284005-9","unstructured":"Atkins AM, Sekar MC. Proton pump inhibitors: Their misuse, overuse, and abuse. IOSR J Pharm 2013;3:25-9"},{"key":"key-10.4103\/1319-2442.284005-10","doi-asserted-by":"crossref","unstructured":"Pasina L, Urru SA, Mandelli S, Giua C, Minghetti P; SGCP Investigators. Evidence- based and unlicensed indications for proton pump inhibitors and patients\u2019 preferences for discontinuation: A pilot study in a sample of Italian community pharmacies. J Clin Pharm Ther 2016;41:220-3","DOI":"10.1111\/jcpt.12371"},{"key":"key-10.4103\/1319-2442.284005-11","doi-asserted-by":"crossref","unstructured":"Vaezi MF, Yang YX, Howden CW. Complications of Proton Pump Inhibitor Therapy. Gastroenterology 2017;153:35-48","DOI":"10.1053\/j.gastro.2017.04.047"},{"key":"key-10.4103\/1319-2442.284005-12","doi-asserted-by":"crossref","unstructured":"Moledina DG, Perazella MA. PPIs and kidney disease: From AIN to CKD. J Nephrol 2016;29:611-6","DOI":"10.1007\/s40620-016-0309-2"},{"key":"key-10.4103\/1319-2442.284005-13","doi-asserted-by":"crossref","unstructured":"Sierra F, Suarez M, Rey M, Vela MF. Systematic review: Proton pump inhibitor- associated acute interstitial nephritis. Aliment Pharmacol Ther 2007;26:545-53","DOI":"10.1111\/j.1365-2036.2007.03407.x"},{"key":"key-10.4103\/1319-2442.284005-14","doi-asserted-by":"crossref","unstructured":"Makunts T, Cohen IV, Awdishu L, Abagyan R. Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis. Sci Rep 2019;9: 2282","DOI":"10.1038\/s41598-019-39335-7"},{"key":"key-10.4103\/1319-2442.284005-15","doi-asserted-by":"crossref","unstructured":"Klepser DG, Collier DS, Cochran GL. Proton pump inhibitors and acute kidney injury: A nested case-control study. BMC Nephrol 2013;14:150","DOI":"10.1186\/1471-2369-14-150"},{"key":"key-10.4103\/1319-2442.284005-16","doi-asserted-by":"crossref","unstructured":"Lazarus B, Chen Y, Wilson FP, Sang Y, Chang AR, Coresh J, et al. Proton pump inhibitor use and the risk of chronic kidney disease. JAMA Intern Med 2016;176:238-46","DOI":"10.1001\/jamainternmed.2015.7193"},{"key":"key-10.4103\/1319-2442.284005-17","doi-asserted-by":"crossref","unstructured":"Nochaiwong S, Ruengorn C, Awiphan R, Koyratkoson K, Chaisai C, Noppakun K, et al. The association between proton pump inhibitor use and the risk of adverse kidney outcomes: A systematic review and meta-analysis. Nephrol Dial Transplant 2018;33:331-42","DOI":"10.1093\/ndt\/gfw470"},{"key":"key-10.4103\/1319-2442.284005-18","doi-asserted-by":"crossref","unstructured":"Sun J, Sun H, Cui M, Sun Z, Li W, Wei J, et al. The use of anti-ulcer agents and the risk of chronic kidney disease: A meta-analysis. Int Urol Nephrol 2018;50:1835-43","DOI":"10.1007\/s11255-018-1908-8"},{"key":"key-10.4103\/1319-2442.284005-19","doi-asserted-by":"crossref","unstructured":"Muriithi AK, Leung N, Valeri AM, Cornell LD, Sethi S, Fidler ME, et al. Biopsy-proven acute interstitial nephritis, 1993-2011: A case series. Am J Kidney Dis 2014;64:558-66","DOI":"10.1053\/j.ajkd.2014.04.027"},{"key":"key-10.4103\/1319-2442.284005-20","doi-asserted-by":"crossref","unstructured":"Surendra M, Raju S, Chandragiri S, Uppin MS, Raju N. Steroid therapy in drug induced acute interstitial nephritis- Retrospective analysis of 83 cases. Saudi J Kidney Dis Transpl 2019;30:157-65","DOI":"10.4103\/1319-2442.252906"},{"key":"key-10.4103\/1319-2442.284005-21","doi-asserted-by":"crossref","unstructured":"Valluri A, Hetherington L, Mcquarrie E, Fleming S, Kipgen D, Geddes CC, et al. Acute tubulointerstitial nephritis in Scotland. QJM 2015;108:527-32","DOI":"10.1093\/qjmed\/hcu236"},{"key":"key-10.4103\/1319-2442.284005-22","doi-asserted-by":"crossref","unstructured":"Brewster UC, Perazella MA. Proton pump inhibitors and the kidney: Critical review. Clin Nephrol 2007;68:65-72","DOI":"10.5414\/CNP68065"},{"key":"key-10.4103\/1319-2442.284005-23","doi-asserted-by":"crossref","unstructured":"Rodriguez-Poncelas A, Barcelo MA, Saez M, Coll-de-Tuero G. Duration and dosing of Proton Pump Inhibitors associated with high incidence of chronic kidney disease in population-based cohort. PLoS One 2018;13: e0204231","DOI":"10.1371\/journal.pone.0204231"},{"key":"key-10.4103\/1319-2442.284005-24","doi-asserted-by":"crossref","unstructured":"Antoniou T, Macdonald EM, Hollands S, Gomes T, Mamdani MM, Garg AX, et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: A population- based cohort study. CMAJ Open 2015;3:E166- 71","DOI":"10.9778\/cmajo.20140074"},{"key":"key-10.4103\/1319-2442.284005-25","doi-asserted-by":"crossref","unstructured":"Lee J, Mark RG, Celi LA, Danziger J. Proton pump inhibitors are not associated with acute kidney injury in critical illness. J Clin Pharmacol 2016;56:1500-6","DOI":"10.1002\/jcph.805"},{"key":"key-10.4103\/1319-2442.284005-26","doi-asserted-by":"crossref","unstructured":"Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G. Proton-pump inhibitors use, and risk of acute kidney injury: A meta-analysis of observational studies. Drug Des Devel Ther 2017;11:1291-9","DOI":"10.2147\/DDDT.S130568"},{"key":"key-10.4103\/1319-2442.284005-27","doi-asserted-by":"crossref","unstructured":"Ikemura K, Oshima K, Enokiya T, Okamoto A, Oda H, Mizuno T, et al. Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: A retrospective cohort study. Cancer Chemother Pharmacol 2017;79:943-9","DOI":"10.1007\/s00280-017-3296-7"},{"key":"key-10.4103\/1319-2442.284005-28","doi-asserted-by":"crossref","unstructured":"Hung SC, Liao KF, Hung HC, Lin CL, Lai SW, Lee PC, et al. Using proton pump inhibitors correlates with an increased risk of chronic kidney disease: A nationwide database-derived case-controlled study. Fam Pract 2018;35:166-71","DOI":"10.1093\/fampra\/cmx102"},{"key":"key-10.4103\/1319-2442.284005-29","doi-asserted-by":"crossref","unstructured":"Klatte DCF, Gasparini A, Xu H, de Deco P, Trevisan M, Johansson ALV, et al. Association between proton pump inhibitor use and risk of progression of chronic kidney disease. Gastroenterology 2017;153:702-10","DOI":"10.1053\/j.gastro.2017.05.046"},{"key":"key-10.4103\/1319-2442.284005-30","doi-asserted-by":"crossref","unstructured":"Peng YC, Lin CL, Yeh HZ, Chang CS, Wu YL, Kao CH. Association between the use of proton pump inhibitors and the risk of esrd in renal diseases: A population-based, case- control study. Medicine (Baltimore) 2016;95: e3363","DOI":"10.1097\/MD.0000000000003363"},{"key":"key-10.4103\/1319-2442.284005-31","first-page":"1482","volume-title":"Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury","author":"Xie","year":"2017","journal-title":"Kidney Int"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:00:45Z","timestamp":1589000445000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.sjkdt.org\/text.asp?2020\/31\/2\/312\/284005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"alternative-id":["284005"],"URL":"https:\/\/doi.org\/10.4103\/1319-2442.284005","relation":{},"ISSN":["1319-2442"],"issn-type":[{"value":"1319-2442","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}