{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:50:07Z","timestamp":1786737007357,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Saudi J Kidney Dis Transpl"],"published-print":{"date-parts":[[2020]]},"DOI":"10.4103\/1319-2442.301203","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T22:03:44Z","timestamp":1605909824000},"page":"982","source":"Crossref","is-referenced-by-count":5,"title":["A Comparative Study of the Use of Dexamethasone, N-acetyl Cysteine, and Theophylline to Ameliorate Renal Ischemia\u2013Reperfusion Injury in Experimental Rat Models: A Biochemical and Immuno-histochemical\nApproach"],"prefix":"10.4103","volume":"31","author":[{"given":"AhmedSalaheldin","family":"Sayed Zeid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SafinazSalaheldin","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1319-2442.301203-1","first-page":"52","volume-title":"Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment","author":"Salvadori","year":"2015","journal-title":"World J Transplant"},{"key":"key-10.4103\/1319-2442.301203-2","first-page":"3279","volume-title":"Ischemia\/ reperfusion injury in kidney transplantation: Mechanisms and prevention","author":"Kosieradzki","year":"2008","journal-title":"Transplant Proc"},{"key":"key-10.4103\/1319-2442.301203-3","first-page":"20","volume-title":"Renal ischemia\/ reperfusion injury; from pathophysiology to treatment","author":"Malek","year":"2015","journal-title":"J Renal Inj Prev"},{"key":"key-10.4103\/1319-2442.301203-4","first-page":"665","volume-title":"Reactive oxygen species and acute renal failure","author":"Nath","year":"2000","journal-title":"Am J Med"},{"key":"key-10.4103\/1319-2442.301203-5","first-page":"89","volume-title":"The importance of the intrarenal renin-angiotensin system","author":"Velez","year":"2009","journal-title":"Nat Clin Pract Nephrol"},{"key":"key-10.4103\/1319-2442.301203-6","unstructured":"Sharfuddin A, Weisbord SD, Palevsky PM, Molitoris BA. Acute kidney injury. In: Brenner and Rector's The Kidney. 10th ed. Philadelphia: ElSevier; 2016. p. 958-1011."},{"key":"key-10.4103\/1319-2442.301203-7","first-page":"221","volume-title":"Serum cystatin C is superior to serum creatinine as a marker of kidney function: A metaanalysis","author":"Dharnidharka","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"key-10.4103\/1319-2442.301203-8","first-page":"383","volume-title":"Gene regulation by the glucocorticoid receptor: Structure:function relationship","author":"Kumar","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"key":"key-10.4103\/1319-2442.301203-9","first-page":"109","volume-title":"N-acetylcysteine, reactive oxygen species and beyond","author":"Sun","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"key-10.4103\/1319-2442.301203-10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/978-3-642-13443-2_15","volume-title":"Methylxanthines and the kidney","author":"Osswald","year":"2011","journal-title":"Handb Exp Pharmacol"},{"key":"key-10.4103\/1319-2442.301203-11","first-page":"1613","volume-title":"Administered mesenchymal stem cells enhance recovery from ischemia\/reperfusion-induced acute renal failure in rats","author":"Lange","year":"2005","journal-title":"Kidney Int"},{"key":"key-10.4103\/1319-2442.301203-12","first-page":"125","volume-title":"Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis","author":"Hassoun","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"key-10.4103\/1319-2442.301203-13","first-page":"2412","volume-title":"Dexamethasone ameliorates renal ischemia-reperfusion injury","author":"Kumar","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"key-10.4103\/1319-2442.301203-14","first-page":"1139","volume-title":"N-acetylcysteine prevents kidney and lung disturbances in renal ischemia\/reperfusion injury in rat","author":"Azarkish","year":"2013","journal-title":"Int J Prev Med","ISSN":"https:\/\/id.crossref.org\/issn\/2008-7802","issn-type":"print"},{"key":"key-10.4103\/1319-2442.301203-15","first-page":"1044","volume-title":"Protective effect of theophylline on renal functions in experimental pneumoperitoneum model","author":"Ozturk","year":"2015","journal-title":"Ren Fail"},{"key":"key-10.4103\/1319-2442.301203-16","first-page":"7","volume-title":"Normalisation of urinary biomarkers to creatinine for clinical practice and research-when and why","author":"Tang","year":"2015","journal-title":"Singapore Med J"},{"key":"key-10.4103\/1319-2442.301203-17","first-page":"486","volume-title":"Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate","author":"Waikar","year":"2010","journal-title":"Kidney Int"},{"key":"key-10.4103\/1319-2442.301203-18","first-page":"180","volume-title":"Serum cystatin C as a marker of renal function in detection of early acute kidney injury","author":"Murty","year":"2013","journal-title":"Indian J Nephrol","ISSN":"https:\/\/id.crossref.org\/issn\/0971-4065","issn-type":"print"},{"key":"key-10.4103\/1319-2442.301203-19","first-page":"295","volume-title":"Cystatin C as a biomarker for estimating glomerular filtration rate","author":"Ferguson","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"key-10.4103\/1319-2442.301203-20","first-page":"1137","volume-title":"Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats","author":"Togashi","year":"2013","journal-title":"Exp Toxicol Pathol"},{"key":"key-10.4103\/1319-2442.301203-21","first-page":"58","volume-title":"Megalin and cubilin in proximal tubule protein reabsorption: From experimental models to human disease","author":"Nielsen","year":"2016","journal-title":"Kidney Int"},{"key":"key-10.4103\/1319-2442.301203-22","first-page":"e0178796","volume-title":"Megalin dependent urinary cystatin C excretion in ischemic kidney injury in rats","author":"Jensen","year":"2017","journal-title":"PLoS One"},{"key":"key-10.4103\/1319-2442.301203-23","first-page":"714","volume-title":"Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology","author":"Christensen","year":"2004","journal-title":"Pediatr Nephrol"},{"key":"key-10.4103\/1319-2442.301203-24","first-page":"12491","volume-title":"Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia","author":"Kozyraki","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/1319-2442.301203-25","first-page":"1955","volume-title":"N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility","author":"Dodd","year":"2008","journal-title":"Expert Opin Biol Ther"},{"key":"key-10.4103\/1319-2442.301203-26","first-page":"732","volume-title":"N-acetylcysteine-induced vasodilation involves voltage-gated potassium channels in rat aorta","author":"Han","year":"2009","journal-title":"Life Sci"},{"key":"key-10.4103\/1319-2442.301203-27","first-page":"738","volume-title":"N- Acetylcysteine-induced vasodilatation is modulated by KATP channels, Na+\/K+- ATPase activity and intracellular calcium concentration: An in vitro study","author":"Vezir","year":"2017","journal-title":"Pharmacol Rep"},{"key":"key-10.4103\/1319-2442.301203-28","first-page":"59","volume-title":"Intravenous N-acetylcysteine for the prevention of contrast-induced nephropathy - A prospective, single-center, randomized, placebo-controlled trial.The INPROC trial","author":"Biernacka-Fialkowska","year":"2018","journal-title":"Postepy Kardiol Interwencyjnej"},{"key":"key-10.4103\/1319-2442.301203-29","first-page":"2203","volume-title":"N-acetylcysteine ameliorates contrast-induced kidney injury in rats with unilateral hydronephrosis","author":"Xia","year":"2018","journal-title":"Mol Med Rep"},{"key":"key-10.4103\/1319-2442.301203-30","first-page":"e0168726","volume-title":"Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-a systematic review and network meta-analysis","author":"Navarese","year":"2017","journal-title":"PLoS One"},{"key":"key-10.4103\/1319-2442.301203-31","first-page":"e004383","volume-title":"Preventive strategies for contrast-induced acute kidney injury in patients undergoing percutaneous coronary procedures: Evidence from a hierarchical Bayesian network meta-analysis of 124 trials and 28 240 patients","author":"Giacoppo","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"key-10.4103\/1319-2442.301203-32","unstructured":"KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl 2012;2 Suppl 1:1-138."},{"key":"key-10.4103\/1319-2442.301203-33","first-page":"2757","volume-title":"N- acetylcysteine and high-dose atorvastatin reduce oxidative stress in an ischemia-reperfusion model in the rat kidney","author":"Cusumano","year":"2015","journal-title":"Transplant Proc"},{"key":"key-10.4103\/1319-2442.301203-34","first-page":"1570","volume-title":"Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia\/reperfusion injury","author":"Sen","year":"2014","journal-title":"Ren Fail"},{"key":"key-10.4103\/1319-2442.301203-35","unstructured":"Zhang L, Zhu Z, Liu J, Zhu Z, Hu Z. Protective effect of N-acetylcysteine (NAC) on renal ischemia\/reperfusion injury through Nrf2"},{"key":"key-10.4103\/1319-2442.301203-36","doi-asserted-by":"crossref","unstructured":"signaling pathway. J Recept Signal Transduct Res 2014;34:396-400.","DOI":"10.3109\/10799893.2014.908916"},{"key":"key-10.4103\/1319-2442.301203-37","first-page":"452","volume-title":"Nephroprotection by theophylline in patients with cisplatin chemotherapy: A randomized, single-blinded, placebo-controlled trial","author":"Benoehr","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"key-10.4103\/1319-2442.301203-38","first-page":"358","volume-title":"Aminophylline effect on renal ischemia-reperfusion injury in mice","author":"Seo","year":"2017","journal-title":"Transplant Proc"},{"key":"key-10.4103\/1319-2442.301203-39","first-page":"1899","volume-title":"BCL- 2 family members and the mitochondria in apoptosis","author":"Gross","year":"1999","journal-title":"Genes Dev"},{"key":"key-10.4103\/1319-2442.301203-40","first-page":"1883","volume-title":"Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1","author":"Abraham","year":"2006","journal-title":"J Exp Med"},{"key":"key-10.4103\/1319-2442.301203-41","first-page":"107","volume-title":"The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation","author":"Zamoyska","year":"2003","journal-title":"Immunol Rev"},{"key":"key-10.4103\/1319-2442.301203-42","first-page":"4719","volume-title":"Glucocorticoid treatment inhibits apoptosis in human neutrophils.Separation of survival and activation outcomes","author":"CoxG","year":"1995","journal-title":"J Immunol"},{"key":"key-10.4103\/1319-2442.301203-43","first-page":"4054","volume-title":"HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK\/NF-\u03baB pathway","author":"Zhang","year":"2016","journal-title":"Am J Transl Res"},{"key":"key-10.4103\/1319-2442.301203-44","first-page":"2366","volume-title":"Administration of dexamethasone protects mice against ischemia\/reperfusion induced renal injury by suppressing PI3K\/AKT signaling","author":"Zhang","year":"2013","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:48:52Z","timestamp":1786733332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.301203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020]]}},"alternative-id":["301203"],"URL":"https:\/\/doi.org\/10.4103\/1319-2442.301203","relation":{},"ISSN":["1319-2442"],"issn-type":[{"value":"1319-2442","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}