{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:20:02Z","timestamp":1793496002825,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Hyponatremic-hypertensive syndrome (HHS) is an uncommon disorder rarely seen in children. Herein, we report a 19-month-old boy with HHS. He had severe hypertension, polyuria, polydipsia, vomiting, and seizure at presentation. Laboratory findings revealed hyponatremia, hypokalemia, metabolic alkalosis, proteinuria, hypercalciuria, high levels of renin and aldosterone, and renal artery stenosis. All symptoms resolved after nephrectomy. Clinicians should be aware of this syndrome because prompt recognition can be lifesaving.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/1319-2442.374386","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T11:42:43Z","timestamp":1681904563000},"page":"S87-S90","source":"Crossref","is-referenced-by-count":1,"title":["Hyponatremic-hypertensive Syndrome in a 19-month-old Boy with Renovascular Hypertension"],"prefix":"10.4103","volume":"33","author":[{"given":"Mehtap Akbalik","family":"Kara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beltinge Demircioglu","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman Cuneyt","family":"Karakus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimet","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithat","family":"Buyukcelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Balat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-11-20230924","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00431-005-0048-1","article-title":"Two cases of hyponatremic-hypertensive syndrome in childhood with renovascular hypertension","volume":"165","author":"Ashida","year":"2006","journal-title":"Eur J Pediatr"},{"key":"R3-11-20230924","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1097\/00006231-199711000-00004","article-title":"The investigation of renovascular hypertension in children: The accuracy of radio-isotopes in detecting renovascular disease","volume":"18","author":"Ng","year":"1997","journal-title":"Nucl Med Commun"},{"key":"R4-11-20230924","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1253\/circj.66.297","article-title":"Hyponatremic-hypertensive syndrome associated with renovascular hypertension: A case report","volume":"66","author":"Tetsuou","year":"2002","journal-title":"Circ J"},{"key":"R5-11-20230924","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2369-5-5","article-title":"Hyponatremic hypertensive syndrome (HHS) in an 18-month old-child presenting as malignant hypertension: A case report","volume":"5","author":"Dixit","year":"2004","journal-title":"BMC Nephrol"},{"key":"R6-11-20230924","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/0002-8703(52)90204-4","article-title":"Unilateral renal artery obstruction associated with malignant nephronsclerosis confined to the opposite kidney","volume":"44","author":"Bauer","year":"1952","journal-title":"Am Heart J"},{"key":"R7-11-20230924","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1136\/bmj.2.5472.1215","article-title":"Plasma renin concentration in human hypertension. 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Renin in relation to aetiology","volume":"2","author":"Brown","year":"1965","journal-title":"Br Med J"},{"key":"R8-11-20230924","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1161\/01.HYP.33.4.1020","article-title":"Hyponatremic-hypertensive syndrome with renal ischemia: An underrecognized disorder","volume":"33","author":"Agarwal","year":"1999","journal-title":"Hypertension"},{"key":"R9-11-20230924","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s12098-012-0908-4","article-title":"Hyponatremic-hypertensive syndrome: Think of unilateral renal artery stenosis","volume":"80","author":"Pandey","year":"2013","journal-title":"Indian J Pediatr"},{"key":"R10-11-20230924","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00467-012-2123-y","article-title":"Hyponatremic hypertensive syndrome in pediatric patients: Is it really so rare?","volume":"27","author":"Kovalski","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"R11-11-20230924","doi-asserted-by":"crossref","first-page":"406515","DOI":"10.4061\/2011\/406515","article-title":"The hyponatremic hypertensive syndrome in a preterm infant: A case of severe hyponatremia with neurological sequels","volume":"2011","author":"van Tellingen","year":"2011","journal-title":"Int J Nephrol"},{"key":"R12-11-20230924","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/pbc.22610","article-title":"Severe polyuria and polydipsia in hyponatremic-hypertensive syndrome associated with Wilms tumor","volume":"55","author":"D'Angelo","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"R13-11-20230924","first-page":"F13","article-title":"Mechanism of angiotensin II-induced proteinuria in the rat","volume":"233","author":"Bohrer","year":"1977","journal-title":"Am J Physiol"},{"key":"R14-11-20230924","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fped.2015.00040","article-title":"Renal artery stenosis precipitates hyponatremic hypertensive syndrome and posterior reversible leukoencephalopathy","volume":"3","author":"Parikh","year":"2015","journal-title":"Front Pediatr"},{"key":"R15-11-20230924","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.pedneo.2016.08.003","article-title":"Hyponatremic hypertensive syndrome in a preterm infant with twin anemia-polycythemia sequence","volume":"58","author":"Lee","year":"2017","journal-title":"Pediatr Neonatol"},{"key":"R16-11-20230924","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00467-006-0107-5","article-title":"Unilateral renal ischemia causing the hyponatremic hypertensive syndrome in children \u2013 More common than we think?","volume":"21","author":"Nicholls","year":"2006","journal-title":"Pediatr Nephrol"},{"key":"R17-11-20230924","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00467-006-0121-7","article-title":"Hyponatraemic-hypertensive syndrome in a 15-month-old child with renal artery stenosis","volume":"21","author":"Seracini","year":"2006","journal-title":"Pediatr Nephrol"},{"key":"R18-11-20230924","first-page":"48","article-title":"Hyponatremic hypertensive syndrome","volume":"60","author":"Peco-Anti\u0107","year":"2007","journal-title":"Med Pregl"},{"key":"R19-11-20230924","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jpurol.2008.01.204","article-title":"Renal artery stenosis with hyponatremic hypertensive syndrome in a 7-year-old child","volume":"4","author":"Neeli","year":"2008","journal-title":"J Pediatr Urol"}],"container-title":["Saudi Journal of Kidney Diseases and Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.374386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:02:59Z","timestamp":1787760179000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/1319-2442.374386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":18,"journal-issue":{"issue":"Suppl 1","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/1319-2442.374386","relation":{},"ISSN":["1319-2442"],"issn-type":[{"value":"1319-2442","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]}}}